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    EFFECTS OF LITHOSPERMIC ACID SUPPLEMENTATION AGAINST ACUTE EXERCISE-INDUCED OXIDATIVE STRESS IN RATS
    (Nobel Ilac, 2024) Coknaz, Hakki; Karaoglan, Esen Sezen; Ozgen, Ufuk
    Objective: The aim of the study was to investigate whether lithospermic acid (LSA), a naturally derived polyphenolic compound, supplementation could prevent acute exercise- induced oxidative damage to skeletal muscle tissue in the rats. Material and Method: Rats were randomly selected and divided into three groups (n= 7/group): Group 1Control group (non-exercise, UT), Group 2- Exercise group (exercise, T) and Group 3- Exercise+lithospermic acid group (exercise+lithospermic acid, T/LSA). At the end of the exercise protocol, the samples were removed from the right leg quadriceps muscle. Malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH) and superoxide dismutase (SOD) levels were measured in the muscle samples. Result: Compared to the UT group, malondialdehyde (MDA) and myeloperoxidase (MPO) activity levels in the muscle tissue of the T group significantly increased (p<0.001). MDA and MPO activity levels significantly decreased in the T/LSA group compared to the T group (p<0.05). Glutathione (GSH) and superoxide dismutase (SOD) activity levels significantly decreased in the T group compared to the UT group (p<0.05). GSH and SOD activity levels in muscle tissue significantly increased in the T/LSA group compared to the T group (p<0.05). No significant difference was found in MDA, MPO, GSH, and SOD levels between the UT group and T/LSA group (p>0.05). Conclusion: In conclusion, our study shows that oxidative activity levels in the muscle tissue of the T/LSA group decreased significantly in skeletal muscle-induced acute exercise in rats, so it can be considered that lithospermic acid has a protective effect against oxidative damage.
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    Protective effects of lupeol on acute exercise-related oxidativestress in male rats
    (Marmara Univ, Fac Pharmacy, 2024) Ozdemir, Emrah; Coknaz, Hakki; Sener, Sila oezlem; Ozgen, Ufuk; Gok, Ali
    The aim of this study is to determine the protective effects of lupeol on acute exhaustive exercise-induced oxidative stress in male rats.Rats were randomly selected and divided into four groups (n=6/group): Control, exercise, lupeol and exercise+lupeol groups. At the end of the exercise protocol, the rats were sacrificed by cervical dislocation, blood samples were taken. The levels of superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione (GSH), coenzyme Q10 (CoQ10) and alpha-lipoic acid (ALA) and oxidative stress levels in serum samples were measured.As a result, it has been determined that lupeol, a natural triterpenoid compound, contributes positively to the level of antioxidants produced by the body and helps suppress oxidants. It has been observed that free radicals caused by oxidative stress that occur as a result of high-intensity exercise are reduced by lupeol. Accordingly, it has been determined that the use of lupeol during exercise in experimental animals exposed tooxidative stress inhibits free radicals formed by stress.In the light of these results, it is thought that lupeol may be included in the composition of pharmaceutical products against exercise-induced oxidative damage