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    Assessment of the Patients with Migraine Related Vertigo that Admitted to the Emergency Department
    (Düzce Üniversitesi, 2015) Delice, Orhan; Ceylan, Mustafa
    Objective: We aimed to provide additional information in order to prevent the misdiagnosisand malpractice in the emergency department by examining the detailed characteristics ofmigraines associated with dizziness.Material and Methods: This is a prospective and cross-sectional study. A hundred consecutivepatients applied with the complaints of both headache and dizziness to emergency departmentwithin 6 months were examined. The patients were referred to neurology polyclinic after thetreatment in emergency department. For each patient, a form containing questions about thespecific symptom, the history and the clinic characteristics was full-filled. The patients weredivided into two groups according to whether there is aura or not, and migraine in the family ornot; than the differences were examined.Results: Eighty-seven of our patients (87%) were female. Forty-one patients (41%) describedaura. Of headache,66% were unilateral and 32% were bilateral. Of the patients,83% experiencednausea, 48% experienced vomiting and 92% described photophobia and phonophobia. Theduration of headache of the migraine patients having a family history of migraine wassignificantly shorter than others. The monthly migraine frequency was significantly higher inpatients having a family history of migraine than the others.Conclusion: Among the patients having a headache and vertigo who applied to emergencydepartment, migraine associated with vertigo should be considered in the young ladies whoseheadache is unilateral and who describes photophobia and phonophobia
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    Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
    (Pergamon-Elsevier Science Ltd, 2011) Sönmez, Fatih; Sevmezler, Sedat; Atahan, Alparslan; Ceylan, Mustafa; Demir, Dudu; Gencer, Nahit; Küçükislamoğlu, Mustafa
    A newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. (C) 2011 Elsevier Ltd. All rights reserved.
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    In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase I and II
    (Taylor & Francis Ltd, 2013) Gençer, Nahit; Bilen, Çiğdem; Demir, Dudu; Atahan, Alparslan; Ceylan, Mustafa; Küçükislamoğlu, Mustafa
    In this study, 4'-(phenylurenyl/thiourenyl) chalcones (14-25) were prepared from 4'-(phenylurenyl/thiourenyl)acetophenones and benzaldehyde derivatives by Claisen-Schmidt condensation. In vitro inhibition effects of chalcone derivatives on purified carbonic anhydrase I and carbonic anhydrase II were investigated by using the CO2 hydration method of Maren. The result showed that all the synthesized compounds inhibited the CA isoenzymes activity. 18 and 19 were found to be most active (IC50 = 25.41 m M and 23.06 mu M) for hCA I, respectively. For hCA II, 24 is the most active compound (IC50 = 14.40 mu M).
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    The Relationship Between Etiology and Genetic Polymorphism in Adults with Cerebral Venous Thrombosis
    (Düzce Üniversitesi, 2019) Şimşek, Fatma; Ceylan, Mustafa; Bilge, Nuray
    Aim: Cerebral venous thrombosis (CVT) is a rare cause of stroke, and there are many factors in its etiology. At least 1/4 of cases is based on thrombophilia. The most common risk factors for thromboembolism were methyl-tetra-hydro-folate reductase (MTHFR) C677T, factor V (FV) G1691A (Leiden), factor II (FII) GA20210 and their mutations. Its relationship with different genetic polymorphisms and high homocysteine levels were also investigated. In this study, it was aimed to investigate the existence of genetic polymorphism and the role of homocysteine levels in CVT etiology.Material and Methods: Demographic characteristics, clinical, radiological and laboratory data of patients diagnosed with CVT between January 2010 and June 2018 were reviewed retrospectively. Etiologic risk factors for CVT and the role of genetic polymorphism in these risk factors were investigated.Results: In this study, 92 (73 female and 19 male) patients and 52 (44 female and 8 male) control subjects were evaluated. The most frequent admission symptom was headache in patients with CVT. MTFHR, factor 13 (F13) V34L, plasminogen activator inhibitory (PAI) and ?-fibrinogen mutations were higher in control group. No statistically significant difference was found between the two groups in terms of FV Leiden, FII, Glycoprotein 3a mutation and homocysteine level.Conclusion: In this study, in addition to the results consistent with the literature, some different results were determined. MTHFR (C677T, A1289C), FV Leiden, FII G20210, ?-fibrinogen 455 G-A, PAI-1 4G/5G polymorphisms do not pose a risk for CVT. F13 V34L polymorphism has a protective role against CVT.