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    (3-(4-chlorophenyl)-4,5-dihydroisoxazole-4,5-diyl)dimethanol Compound: Antibacterial Activity, Antifungal Activity and Calculated Structural Parameters
    (2022) Pir, Meryem; Budak, Fatma
    We intended to quantify the antibacterial and antifungal activity results of 4,5-dihydroisoxazole dimethanol compound (1a) against several bacteria and fungi and also calculate some structural parameters (theoretical descriptors) of compound (1a) with this work. Microdilution broth procedures were studied using microdilution wells for the minimal inhibitory concentrations (MICs) test. Compound (1a) exhibited fair activities against all the bacteria and fungi. Compound (1a) has been a good result (MIC = 50 ?g/ml) against particularly P. aeruginosa. The structure of compound (1a) was drawn, and geometrical optimization was done using the Ab initio (RHF/3- 21G) level.
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    Nanoparticle-supported electrochemical sensors for pesticide analysis in fruit juices
    (Elsevier B.V., 2025) Piskin, Ensar; Alakus, Zeynep; Budak, Fatma; Cetinkaya, Ahmet; Ozkan, Sibel A.
    Pesticides, used to destroy insects, diseases, and weeds in agricultural products, have increased agricultural activities in countries in recent years. While they have helped reduce the number of pests affecting crops and improved agricultural yields, they have also caused significant environmental hazards. Their toxicity damages the habitats of beneficial creatures, wild animals, and the targeted pests. Additionally, pesticides have a lengthy half-life in the environment, which allows them to build up in species' tissues and go up the food chain, a process known as bioaccumulation and biomagnification. This is a danger to both ecological balance and human health. While a certain amount of excessively used pesticides has a positive effect, increasing amounts remain in the soil and environment as residues. Pesticide residues in the soil pass into foods and fruits. Therefore, there has been a critical need to design electrochemical sensors for sensitive, selective, and rapid analysis of pesticides. Electrochemical sensors offer economical, cost-effective, easy to apply, environmentally friendly, sensitive, and selective advantages for quality and reliable analysis of foods. In addition, many functional nanomaterials are used to increase these sensors' innovative designs and selective and sensitive structures. In this review, the properties, structures, and recent developments regarding the use of the most commonly used nanomaterials in electrochemical sensors designed for pesticide analysis are examined in detail. Furthermore, the requirements, structural features, and future development of electrochemical sensors that can be prepared cost-effectively and rapidly for sensitive and selective analysis of fruit pesticide residues have been examined and explained in detail. For this reason, the studies in the literature on pesticide analysis in fruits in the last 5 years are summarized, and some studies are explained in detail. Finally, this study will shed light on the studies on fruit pesticide analysis. © 2025 Elsevier B.V., All rights reserved.
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    Recent developments in electrochemical sensors for the detection and real-time monitoring of non-steroidal anti-inflammatory drugs
    (Pergamon-Elsevier Science Ltd, 2025) Alakus, Zeynep; Piskin, Ensar; Budak, Fatma; Kaya, S. Irem; Cetinkaya, Ahmet; Ozkan, Sibel A.
    The most commonly used medications to control fever, pain, and inflammation are non-steroidal anti-inflammatory drugs (NSAIDs). However, excessive use of them can have negative health consequences on humans, and their uncontrolled disposal in ecosystems raises serious environmental issues. Electrochemical sensors offer enormous potential for the sensitive, selective, effective, and economical detection of pharmaceuticals in complicated media, surpassing the drawbacks of conventional detection techniques. An overview of the most recent advancements in electrochemical sensors that use nanoscale materials as electrode modifiers that target NSAIDs, such as metallic nanomaterials, carbon-based materials, and hybrid materials, is provided in this review. Analysis of real samples, sensor/analyte interactions, and various electrode fabrication techniques was particularly taken into consideration. The studies in the literature were summarized in detail in terms of various analytical properties, such as linearity range, limit of detection (LOD), limit of quantification (LOQ), and detection method, among others. The experimental results were then discussed. Finally, this review discusses the potential, challenges, and opportunities in designing next-generation advanced sensing devices.