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    Diagnostic approach of tuberculous lymphadenitis in a multicenter study
    (J Infection Developing Countries, 2024) Yenilmez, Ercan; Ozakinsel, Duygu; Kose, Adem; Olcar, Yildiz; Duman, Zehra; Ceylan, Mehmet R.; Bozkurt, Fatma
    Introduction: Tuberculous lymphadenitis (TBLN) is the most common infectious etiology of peripheral lymphadenopathy in adults, in Turkiye. This study aimed to identify the demographic, clinical, and laboratory variables that differentiate TBLN from non-tuberculous lymphadenitis (NTBLN), as well as the etiology of lymphadenopathy in adults. Methodology: Patients who were over 18 years old and were referred to the infectious disease outpatient clinics with complaints of swollen peripheral lymph nodes, and who underwent lymph node biopsy between 1 January 2010 and 1 March 2021, were included in this multicenter, nested case-control study. Results: A total of 812 patients at 17 tertiary teaching and research hospitals in Turkiye were included in the study. TBLN was the most frequent diagnosis (53.69%). The proportion of patients diagnosed with TBLN was higher among females; and among those who had a higher erythrocyte sedimentation rate, positive purified protein derivative test, and positive interferon -gamma release test result ( p < 0.05). However, TBLN was less frequent among patients with generalized lymphadenopathy, bilateral lymphadenopathy, axillary lymphadenopathy, inguinal lymphadenopathy, hepatomegaly, splenomegaly, leukocytosis, and moderately increased C reactive protein levels ( p < 0.05). Conclusions: Identifying the variables that predict TBLN or discriminate TBLN from NTBLN will help clinicians establish optimal clinical strategies for the diagnosis of adult lymphadenopathy.
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    The Role of Trace Elements in Helicobacter Pylori Infected Patients
    (Kuwait Medical Assoc, 2011) Bozkurt, Fatma; Gülsün, Serda; Üstün, Cemal; Geyik, Mehmet Faruk; Hoşoğlu, Salih
    Objective: To evaluate the effect of trace elements in patients with Helicobacter pylori associated chronic gastritis Design: Prospective study Settings: Clinical services of the clinical microbiology and infectious diseases and gastroenterology clinics at Dicle University, Turkey Subjects:A total of 92 patients with variable severity of chronic gastritis (45 Helicobacter pylori positive and 47 Helicobacter pylori negative gastritis) and 90 age and sex matched healthy subjects were included in the study conducted between October 2006 and November 2008. Intervention: Histopathologic examination, culture of Helicobacter pylori and urease tests were performed for each patient. The atomic absorption spectrophotometer was used in the measurement of trace elements in the serum. Main Outcome Measures: Serum copper and zinc levels were significantly elevated in patients with Helicobacter pylori associated gastritis compared to Helicobacter pylori negative gastritis and healthy controls (p < 0.0001). Serum copper, zinc and Cu / Zn levels in patients with Helicobacter pylori negative chronic gastritis was not significantly different from the serum levels in healthy controls (p > 0.05). Conclusions: Our results suggest a relationship between Helicobacter pylori associated chronic gastritis and the elevation of trace element levels in serum. This study confirms that the elevation of trace element levels in serum (Cu and Zn levels) will be helpful in the diagnosis of Helicobacter pylori associated chronic gastritis in the abscence of invasive procedures, and is useful in predicting the severity of infection in patients with chronic gastritis.
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    The role of trace elements in wagner classified diabetic patients
    (Academic Journals, 2011) Bozkurt, Fatma; Gülsün, Serda; Üstün, Cemal; Geyik, Mehmet Faruk; Teğin, İbrahim; Satıcı, Ömer
    Wagner's classification is the most widely used grading system in diabetic foot infections. The aim of this study was to evaluate the role of the trace elements in diabetic foot infected patients graded with Wagner's classification. This prospective study was carried out on 50 diabetic patients with variable severity of foot infections and 50 age and sex matched healthy subjects in Dicle University, Turkey, between October 2006 and November 2008. Diabetic foot infections were graded according to Wagner classification and deep tissue cultures were performed from all diabetic foot infected patients. The atomic absorption spectrophotometer was used in the measurement of trace elements in the serum. serum zinc and copper levels were significantly elevated in patients with Wagner 3 and 4 compared to Wagner 2 and 1 graded patients and healthy controls. Also Wagner 1 and 2 graded patients had higher serum zinc levels compared to healthy controls (p < 0.001). This study confirms that trace elements may be used as a leading sign to determine the severity of infections in diabetic foot wounds and may be used to predict outcome of diabetic foot infections.