Yazar "Bozkurt, E." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Evaluation of the Ocular Surface, Conjunctival Impression Cytology and Meibomian Gland Dropout in Patients with Familial Mediterranean Fever
    (Elsevier Masson s.r.l., 2021) Bozkurt, E.; Muhafiz, E.; Erat, Y. E.; Arslan, E. Ö.; Bozkurt, H. B.; Erguven, M.
    Purpose: Familial Mediterranean fever (FMF) is an idiopathic disease with chronic inflammation. We aimed to determine the changes caused by the chronic inflammatory nature of FMF on the ocular surface, meibomian glands (MG), and conjunctiva via conjunctival impression cytology (CIC). Material-method: Forty-two FMF patients with a mean age of 11.93 ± 3.92 years and 36 control patients with a mean age of 11.83 ± 3.38 years were included in the study. Ocular surface anomalies of the patients were evaluated using Schirmer II, TBUT and OSDI. MG function (meibum quality), morphology (meiboography), and CIC were evaluated. Results: Although there was a significant difference between the groups in terms of Schirmer II and TBUT, OSDI scores did not significantly differ (P = 0.022, 0.010, and 0.099 respectively), and no significant dry eye sign was observed in either group. There was significant difference between the groups in terms of the percent area of MG dropout, MG density, meiboscore (P = 0.020, 0.023, and 0.031 respectively), but no significant difference was observed in relation to MG quality (P = 0.650). Although conjunctival impression cytology was of a higher grade in the patients with FMF according to Nelson's classification, no significant difference was observed between the groups (P = 0.109). Conclusion: Although there was a decrease in the number of MGs in FMF patients, no significant deterioration was observed in conjunctival cytology. In these patients, tear film stability may deteriorate in particular. Clinicians should be aware of the possibility of ocular surface disease secondary to MG dropout in patients with FMF. © 2021 Elsevier Masson SAS
  • Küçük Resim Yok
    Öğe
    Evaluation of the relationship between clinical parameters and retinal microvascular structures in children with atopic dermatitis: An optical coherence tomography angiography study
    (Masson Editeur, 2026) Bozkurt, E.; Celikera, S.; Bozkurt, H. b.; Toprak, G.; Meydan, B.
    Purpose. - This study aimed to evaluate retinal structural and microvascular changes in children with atopic dermatitis (AD) using optical coherence tomography (OCT) and OCT angiography (OCTA) and to analyze their associations with disease severity, comorbidities, corticosteroid use, and IgE levels. Methods. - A prospective, cross-sectional case-control study included 43 children with AD and 32 age-and sex-matched healthy controls. Peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell layer (GCL) thicknesses were measured by spectral-domain OCT. Retinal microvasculature was assessed by OCTA with 6 & times; 6 mm macular scans. Vascular densities in superficial and deep capillary plexuses and choriocapillaris were calculated using the ETDRS grid. Clinical data included SCORAD scores, serum IgE, skin hydration, eosinophil counts, and duration of corticosteroid use. Results. - Children with AD showed significantly reduced superior and temporal RNFL thickness compared with controls (P < 0.05). Central and superior GCL thicknesses were lower but not significantly so. Foveal vascular density of the superficial plexus was significantly reduced in AD (18.7 +/- 3.3% vs. 20.4 +/- 3.4%, P = 0.039). Correlation analyses showed superior RNFL thickness positively associated with skin hydration, whereas inferior GCL thickness correlated negatively. Longer corticosteroid use correlated with increased foveal superficial and superior deep vascular density, while serum IgE correlated positively with superior deep density and negatively with nasal density. Conclusion. - Pediatric AD may be linked to selective RNFL thinning and subtle macular vascular alterations, reflecting systemic inflammation. OCT and OCTA may serve as biomarkers for monitoring severity and early ocular involvement, underscoring the importance of interdisciplinary care. (c) 2026 Published by Elsevier Masson SAS.