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  • Küçük Resim
    Öğe
    Factors associated with glomerular filtration rate variation in primary hyperparathyroidism after parathyroidectomy
    (2019) Çalışkan, Mustafa; Kızılgül, Muhammed; Beysel, Selvihan; Uçan, Bekir; Akcan, Fatih Alper; Takır, Mümtaz; Çakal, Erman
    Background/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advancedprimary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence,we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated withGFR variation in these patients.Materials and methods: One hundred and twenty-five patients with PHPT who underwent surgery between 2012 and 2014 wereenrolled in the study. Patients were divided into two groups according to GFR values: patients whose GFR was lower than 60 mL/min/1.73 m2 and higher than 60 mL/min/1.73 m2. Demographic and laboratory parameters were compared before and 6 months afterparathyroidectomy.Results: Prevalence of antihypertensive drug users and patients with renal cysts and parathormone (PTH) and alkaline phosphataselevels were higher in patients with GFR of ?60 than in GFR of <60 mL/min/1.73 m2 (P < 0.05). Systolic BP, uric acid, and magnesium weredecreased in patients with GFR of ?60, but GFR did not change in the two groups after parathyroidectomy. After parathyroidectomy,calcium and PTH decreased but 25(OH)D3 and phosphorus increased in the two groups. In multiple regression analysis, age, calcium,and baseline GFR were independent predictors of GFR variation. Parathyroid adenoma volume and urinary calcium were notindependent predictors of GFR change.Conclusion: Older age, higher preoperative calcium, and GFR were factors associated with GFR increase in PHPT patients afterparathyroidectomy. Further renal impairment was prevented by parathyroidectomy in PHPT patients.
  • Küçük Resim Yok
    Öğe
    Subklinik Hipotiroidili Hastalarda Tiroksin Tedavisinin Kardiyovasküler Risk Faktörleri Üzerine Etkisi
    (Düzce Üniversitesi, 2021) Beysel, Selvihan; Apaydın, Mahmut; Çalışkan, Mustafa; Özbek, Mustafa; Çakal, Erman
    Amaç: Subklinik hipotiroidizm (SH) kardiyovasküler risk faktörleri (KVR) üzerinde zararlı bir etkiye sahiptir; ancak tedavi edilip edilmemesi halen tartışmalıdır. Çalışmanın amacı, SH hastaların KVR’ini belirlemek ve kısa süreli tiroksin tedavisinin bunlara etkisini araştırmaktır.Gereç ve Yöntemler: Bu retrospektif çalışmaya SH grubu(n=30) ve yaş-cinsiyet eşleştirilmiş kontrol grubu (n=40) dahil edildi. SH hastalarına 3 ay boyunca 50 ?g/gün tiroksin tedavisi verildi. Tedaviden önceki KVR, tedaviden sonraki KVR ile karşılaştırıldı.Bulgular: Kontrol (kadın %66,7; yaş 45,76±14,55 yıl) ve SH (kadın %77,3; yaş 45,23±12,02 yıl) grubu arasında, cinsiyet dağılımı ve yaş ortalaması benzerdi (p>0,05). Vücut kitle indeksi (VKİ) SH grubunda (32,66±5,57 kg/m2), kontrol grubundan (25,13±3,20 kg/m2) daha yüksekti. Başlangıçta, SH grubunda serum glukoz (83,76±9,51 vs 91,73± 9,96 mg/dl), toplam kolesterol (162,36±13,41 vs 184,21±51,91 mg/dl), düşük-yoğunluklu lipoprotein-kolesterol (LDL-C; 91,73±22,04 vs 104,61±11,36 mg/dl), C-reaktif protein (hs-CRP; 1,53±0,66 vs 2,63±0,93 mg/L) düzeyi, kontrol grubuna göre daha yüksekti (p