Yazar "Beyazcicek, Ersin" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim Yok
    Öğe
    Effect of acute and chronic ellagic acid administration on penicillin induced epileptiform activity in rats
    (Natl Inst Science Communication-Niscair, 2024) Beyazcicek, Ersin; Ankarali, Seyit; Beyazcicek, Ozge; Ankarali, Handan
    One of the flavonoids found in some fruits and plants such as pomegranates, nuts, and apples is ellagic acid (EA). This compound has antidepressant, anxiolytic, antioxidant, and anti-inflammatory effects. Aim of this study was to investigate the effects of EA on experimental penicillin-induced epilepsy model electrophysiologically in rats. In this study, 70 adult male Wistar rats were divided into acute and chronic main groups. Only EA, and 10, 50 and 100 mg/kg doses of EA were the subgroups of the study. Sham and control groups were used as common groups for acute and chronic main groups. Substances were given to the acute group 30 min before the epileptiform activity started but for 21 days to the chronic group. Rats were anaesthetized with urethane. Electrodes were placed on the left somatomotor area. Electrocorticography (ECoG) recording was started and then penicillin was injected into the rats to induce epileptiform activity. 120 min more ECoG recordings were taken after penicillin was injected. In sham and only EA groups there was no epileptiform activity. Both acute and chronic groups of EA significantly increased the latency time to onset of the first spike-wave (P<0.05) and decreased the frequency and amplitude except for some time periods (P<0.05). Consequently, the administration of EA has an antiepileptic effect in penicillin-induced epilepsy in rats. Therefore it may be a potential anti-epileptogenic drug in the future.
  • Küçük Resim Yok
    Öğe
    The Effects of Individual Components of E-Cigarettes on Ion Transport and Airway Surface Liquid Height in Human Bronchial Epithelial Cells
    (Mdpi, 2025) Beyazcicek, Ozge; Tarran, Robert; Ozmerdivenli, Recep; Beyazcicek, Ersin
    Background and Objectives: The rising popularity of new-generation electronic cigarettes (e-cig) like JUUL necessitates a better understanding of their impact on respiratory and other body systems, as the effects of JUUL's components remain unclear. This study aimed to investigate the effects of JUUL components on ion channels and airway surface liquid (ASL) height in human bronchial epithelial cells (HBECs). Furthermore, the cytotoxic effects of these components were investigated in human embryonic kidney 293T (HEK293T) cells. Materials and Methods: The components tested included nicotine salt (NicSalt), benzoic acid (BA), sodium hydrogen tartrate (NaTar), propylene glycol/vegetable glycerin (PG/VG), freebase nicotine (FBNic) and nicotine salt+benzoic acid (NicSalt+BA). Each component was prepared at 100 mu M, and HBECs were exposed for 24 h to measure ASL height, short-circuit current (Isc), and transepithelial electrical resistance (TEER). Results: Initial exposure (0 h) to these substances did not significantly alter ASL height. However, after 2 h, FBNic-treated HBECs exhibited a significant reduction in ASL height compared to NicSalt and other tested substances, with the most pronounced decrease observed at the 6th hour. This effect persisted over prolonged exposure, suggesting a cumulative impact on airway hydration and epithelial function. Additionally, adenosine administration did not induce a significant increase in ASL height. NicSalt, BA, and FBNic were found to disrupt ion balance in HBECs, affecting ion channels and ASL homeostasis while significantly decreasing TEER. In terms of cytotoxicity, NicSalt, and benzoic acid demonstrated minimal cytotoxicity at low concentrations, whereas FBNic showed significantly higher cytotoxicity at moderate levels. Conclusions: In conclusion, this study highlights that e-cigarette components can disrupt airway surface liquid homeostasis by affecting ion channel activity, compromise epithelial barrier integrity by reducing transepithelial electrical resistance, and emphasize the importance of their cytotoxic effects.
  • Küçük Resim Yok
    Öğe
    Efficacy of Sinapic Acid Administration in a Model of PenicillinInduced Epilepsy
    (Wiley, 2023) Coskun, Ayca; Beyazcicek, Ersin; Beyazcicek, Ozge; Gok, Ali
    [No abstract available]
  • Küçük Resim Yok
    Öğe
    Investigation of The Effects of Fatty Acids on Growth Hormone, Insulin-like Growth Factor 1, and Insulin- and Hormone-sensitive Lipase Levels in Rats
    (Galenos Publ House, 2024) Emir, Aysegul; Beyazcicek, Ozge; Beyazcicek, Ersin; Gok, Ali
    Objective: Several studies have investigated hormones such as growth hormone (GH), insulin (INS), insulin-like growth factor-1 (IGF-1), and hormone- sensitive lipase (HSL). However, there is insufficient data on the effects of the combination of short-, medium-, and long-chain fatty acids on hormone concentrations in serum/tissue, including GH, INS, IGF-1, and HSL. The purpose of this study was to investigate the effects of butyric acid (BA), caprylic acid (CA), and oleic acid (OA) alone or in combination on GH, INS, IGF-1, and HSL secretion. Methods: Fifty-six male Wistar rats were used in the study. The animals were separated into 8 subgroups: control, BA, CA, OA, BA + CA, BA + OA, CA + OA, and BA + CA + OA groups. Fatty acids were administered orally to rats for 21 days. At the end of the study, GH, IGF, INS, and HSL levels were measured in serum using the enzyme-linked immunosorbent assay method. Results: BA administration reduced GH, IGF-1, and INS levels but had no significant effect on HSL levels. CA administration increased HSL levels but had no significant effect on GH, INS, and IGF-1 levels. OA administration increased GH and HSL levels but had no significant effect on IGF-1 and INS levels. Conclusion: The combined use of fatty acids increased GH levels while decreasing INS, IGF-1, and HSL levels.