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Öğe Can in vitro maturation overcome cycles with repeated oocyte maturation arrest? A classification system for maturation arrest and a cohort study(Wiley, 2021) Hatirnaz, Safak; Basbug, Alper; Hatirnaz, Ebru; Tannus, Samer; Hatirnaz, Kaan; Bakay, Kadir; Dahan, Michael H.Objective To investigate the role of gonadotropin-stimulated and human chorionic gonadotropin (hCG) -primed in vitro oocyte maturation (IVM) in cases of repeated in vitro fertilization (IVF) failure due to various forms of oocyte maturation arrest (OMA). Methods Retrospective cohort study. Results In all, 63 women with IVF failure due to OMA were evaluated in this study. According to the Hatirnaz & Dahan classification, 11 (17.5%) women were OMA type 1, 22 (34.9%) were OMA type 2, 0 were OMA type 3, 11 (17.5%) were OMA type 4, and 19 women were OMA type 5 (30.1%). Fewer oocytes were retrieved in the IVM than in the IVF cycles. No embryos were produced from oocytes collected in the IVM cycles of women with OMA types 1, 2, and 4. In the OMA type 5 group, 9 (47.4%) day 2 embryos and 6 (31.6%) day 3 embryos were obtained. The difference between the groups was statistically significant (P = 0.001, P = 0.002, respectively). Single day 3 embryo transfer was performed for the six patients with OMA type 5 but no clinical pregnancies occurred. Conclusions Follicle-stimulating hormone-stimulated and hCG-primed IVM does not improve oocyte maturation, developmental potential, or pregnancy rates of women with OMA. Future studies directed to re-establishing normal cytoskeletal architecture and machinery, and resumption of meiosis may be beneficial for obtaining mature oocytes.Öğe Comment on 'A novel technique in the management of severe postpartum uterine atony bleeding: Three vertical uterine compression sutures'(Elsevier, 2021) ilmaz, Mehmet; Basbug, Alper[Abstract Not Available]Öğe A Comparative Multicentric Study on Serosal and Endometrial Myomectomy During Cesarean Section: Surgical Outcomes(Taylor & Francis Inc, 2021) Hatirnaz, Safak; Guler, Oguz; Basbug, Alper; Cetinkaya, Mehmet Bilge; Kanat-Pektas, Mine; Bakay, Kadir; Kalkan, UzeyirObjective: This multi-center study aims to determine the efficiency and safety of endometrial myomectomy (EM) for the removal of uterine fibroids during cesarean section (CS). Methods: Retrospective review of 360 women diagnosed for fibroids during pregnancy. They all delivered by CS between 2014 and 2019. The study groups included 118 women who only underwent EM, 120 women who only had subserosal myomectomy by traditional technique and 122 women with fibroids who decided to avoid cesarean myomectomy, as control group. They were analyzed and compared the surgical outcomes. Results: The EM, subserosal myomectomy and control groups were statistically (p > 0.05) similar for to age, body mass index (BMI), gravidity, parity, gestational age at delivery, indications for CS, number of excised fibroids, size of the largest myoma. Postoperative hemoglobin values and ? (?) hemoglobin concentrations were lower in SM group (10.39gr/dl vs 9.98 gr/dl vs 10.19 - 1.44 gr/dl vs 1.90 gr/dl vs 1.35; p = 0.047, p = 0.021; respectively) Hybrid fibroids were significantly more frequent in the EM group than subserosal myomectomy and control groups (respectively, 33.1% vs 23.3% vs 27.0%, p = 0.002). Surgery time was significantly longer in the subserosal myomectomy group than EM and control groups (respectively, 46.53 min vs 37.88 min vs 33.86 min, p = 0.001). Myomectomy took significantly longer time in the subserosal myomectomy than EM group (13.75 min vs 8.17 min, p = 0.001). Conclusions: Endometrial myomectomy is a feasible choice for treatment of fibroids during CS, and, basing on our results could be an alternative to traditional cesarean subserosal myomectomy.Öğe Comparison of the Efficacies of Sacrospinous Ligament Fixation and Laparoscopic Lateral Suspension in the Treatment of Apical Prolapse: 24-Month Follow-Up Results(Imr Press, 2025) Yurtcu, Engin; Keyif, Betul; Sarigedik, Burcu; Basbug, Alper; Tinelli, AndreaBackground: Pelvic organ prolapse (POP) significantly impacts the quality of life, particularly in older women with a history of vaginal deliveries. Although conservative treatments provide some symptom relief, surgical interventions are more effective for managing POP. This study compares the outcomes and effectiveness of sacrospinous ligament fixation (SSLF) and laparoscopic lateral suspension (LLS) surgeries in the treatment of POP.Methods: This retrospective comparative cohort study included patients with symptomatic stage 2 or higher apical POP, treated at a tertiary hospital in Turkey between April 2021 and June 2022. Patients were treated with either SSLF or LLS surgeries and underwent preoperative and postoperative evaluations using the Prolapse Quality of Life (P-QoL) questionnaire and the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12). Patients were divided into two groups: SSLF (n = 47) and LLS (n = 44). The primary outcome was the rate of anatomical failure, while secondary outcomes included improvements in functional capability and quality of life.Results: The study found that the rate of postoperative anterior compartment failure was significantly lower in the LLS group compared to the SSLF group (p = 0.005). The success rate of LLS for apical prolapse was 100%, compared to 93.6% for SSLF. In the posterior compartment, SSLF demonstrated a higher success rate (86.2%) than LLS (68.5%). Both procedures improved P-QoL scores and the PISQ-12 subscales; however, a significant improvement in total PISQ-12 scores was observed only in the LLS group (p = 0.009).Conclusions: Both SSLF and LLS are effective in treating POP and enhancing quality of life. However, LLS demonstrated higher success rates for anterior and apical prolapse, while SSLF was more effective in addressing in posterior compartment defects.Öğe Diagnosis of genital tuberculosis on menstrual blood during infertility explorations(Elsevier, 2021) Yilmaz, Mehmet; Basbug, Alper[Abstract Not Available]Öğe Does Uterine Manipulator Type Affect Surgical Outcomes of Laparoscopic Hysterectomy?(Wolters Kluwer Medknow Publications, 2021) Yavuzcan, Ali; Altintas, Rasit; Yildiz, Gazi; Basbug, Alper; Bastan, Merve; Caglar, MeteObjectives: Many surgeons use uterine manipulator (UM) during laparoscopic hysterectomy (LH). In this study, we aimed to compare the outcomes of LH operations performed by using partially reusable UM with the articulated system (artUM) and disposable (dUM) UM without articulation. Materials and Methods: A total of 99 patients underwent the LH operation. This study was carried out with 35 of those 99 Caucasian patients who met the inclusion criteria. Group 1 consisted for 7 LH operations using the articulated RUMI (R) II/KOH-Efficient (TM) (Cooper Surgical, Trumbull, CT, USA) system (artUM), while Group II consisted of 28 patients using old-type V Care (R) (ConMed Endosurgery, Utica, New York, USA) dUM as UM. Results: Mean operation time was found to be 157.1 +/- 42.0 min. The operation time was found statistically longer in Group 1, consisted of artUM used patients (P = 0.006 and P < 0.05). No statistically significant difference was found between two groups in terms of surgical results such as, delta hemoglobin value (P = 0.483 and P < 0.05), length of hospital stay (P = 0.138 and P < 0.05), and postoperative maximum body temperature (P = 0.724 and P < 0.05). Conclusion: The UM type did not alter the surgical outcomes except the operating time in our study. According to our results, the surgical technique is a more significant variable than instruments used in LH for normal size uterus. Further prospective, large-scale studies comparing various UM systems are mandatory.Öğe Early versus delayed removal of indwelling catheters in patients after elective cesarean section: a prospective randomized trial(Taylor & Francis Ltd, 2020) Basbug, Alper; Yuksel, Alpaslan; Kaya, Aski EllibesPurpose: We conducted a prospective randomized controlled trial to compare postoperative urinary catheter removal 2 versus 12?h after elective cesarean section in terms of irritative symptoms, first void time, incidence of urinary tract infection, postoperative mobilization time, and hospitalization time. Methods: A total of 134 women admitted to Duzce University Hospital for primary or recurrent elective cesarean section were randomized into two groups. A total of 62 women were enrolled in the early group, with indwelling catheter removal 2?h after cesarean section; 74 women were enrolled in the delayed group, with catheter removal 12?h after the cesarean section. The groups were prospectively compared in terms of irritative urinary symptoms, bacteriuria, hematuria, length of hospital stay, and mobilization time. Results: Urinary frequency (p?=?.04), microscopic hematuria incidence (p?=?.04), postoperative mobilization time (p?=?.01), and length of hospital stay (p?=?.009) were significantly lower in the early group than in the delayed group. There were no significant differences in terms of bacteruria, urinary retention, dysuria, and first postoperative voiding time. Conclusions: Early removal of urinary catheters after elective cesarean section is associated with reduced mobilization time and hospital stay.Öğe The Effect of Hands-On Cadaver and Live Surgery Practice on Surgeons' Performance in Urogynecologic Operations: One-Year Follow-Up(Mary Ann Liebert, Inc, 2020) Akar, Bertan; Aslancan, Reyhan; Dogan, Ozan; Basbug, Alper; Sivaslioglu, Akin; Caliskan, ErayObjective: Surgical procedures need a combination of theoretical knowledge and practical experience to be performed properly. Postresidency education programs provide opportunities to practice new surgical techniques. This article evaluates 2 different educational strategies for learning new techniques in the field of urogynecology. One of the strategies is commonly practiced theoretical education plus observation of live surgeries, and the other strategy is a threefold approach of theoretical education, as well as cadaver training and performing live surgery. Materials and Methods: The study was designed as a prospective cohort study. The occupational experiences of 58 obstetricians and gynecologists were documented prior to the educational interventions. Two groups were created, based on the participants' preferences. Group 1 had theoretical education followed by observation of live surgery through broadcasting. Group 2 had theoretical education, plus a 1-day cadaver-based surgery course, as well as assisting tutors in hands-on operations. At a 1-year follow up, different types of surgeries performed throughout the year by each surgeon were recorded and analyzed using SPSS. Results: Prior to the course, both groups had similar experiences in urogynecologic operations (p > 0.05). In Group 2, significantly more surgeons began to perform tension-free vaginal tape (TVT) interventions regularly after the course (p < 0.001), a procedure considered more technically demanding. Surgeons utilizing any of the midurethral slings including TVT, transobturator tape, or mini-slings increased by 20% in Group 2, a statistically significant increase (p = 0.03). Conclusion: A threefold approach of theoretical education, cadaver practice, and live surgery significantly increases surgeon adaptation to utilization of midurethral slings, compared to exclusively theoretical education with observation of live surgery. (J GYNECOL SURG 20XX:000)Öğe Evaluation of Effectiveness of Laser Assisted Hatching Pregnancy Rates on Fresh IVF / ICSI Cycles(Gazi Univ, Fac Med, 2020) Artar, Ishak; Karli, Pervin Ertargin; Basbug, Alper; Basbug, Derya; Eyi, Elif Gul Yapar; Dugan, MuammerObjectives: To investigate the effects of laser assisted hatching (LAHA) implantation rates, clinical pregnancies, and live births of the patients enrolled in a fresh in vitro fertilization and intracytoplasmic sperm injection-embryo transfer (IVF/ICSE-ET) program. Material and Methods: A total of 315 patients who underwent at least two unsuccessful ETs or had a baseline follicle-stimulating hormone (FSH) level of >= 10 mIU/mL and who underwent IVF/ICSE-ET at IVF Center. The patients were divided into two groups: patient group (n=100) who underwent LAHA and control group (n=215) who did not. The beta human chorionic gonadotropin (I3hCG) positivity, clinical pregnancies, and live births of both groups were compared. Results: There was no significant difference in the clinical pregnancy and implantation rates between the groups including those with an advanced maternal age or recurrent implantation failure. In the patients with elevated FSH levels (FSH >= 10 mIU/mL), these rates were significantly lower in the study group, compared to the control group. Conclusion: Our study results show that laser assisted hatching does not improve the biochemical, clinical, and take home baby rates in IVF / ICSI - ET patients.Öğe An Exploratory Study of Serum Vasorin Levels in Polycystic Ovary Syndrome: A Novel Potential Biomarker for Diagnosis and Pathogenesis(Mdpi, 2025) Keyif, Betul; Yurtcu, Engin; Basbug, Alper; Yavuzcan, Ali; Goynumer, Fikret GokhanObjective: This study aims to investigate the potential role of vasorin as a novel biomarker in the pathogenesis of polycystic ovary syndrome (PCOS) by evaluating serum vasorin levels in women diagnosed with PCOS. Methods: A prospective study was conducted at D & uuml;zce University Faculty of Medicine between March and July 2024, including 92 women with PCOS, diagnosed based on the 2003 Rotterdam criteria, and 68 age- and BMI-matched healthy controls. Serum vasorin levels were measured using an enzyme-linked immunosorbent assay (ELISA) and compared between the two groups. Additionally, correlations between vasorin levels and metabolic, inflammatory, and hormonal parameters were analyzed. Results: Women with PCOS had significantly lower serum vasorin levels (median: 0.70 pg/mL) compared to the control group (median: 2.36 pg/mL, p < 0.001). No significant correlation was found between vasorin and metabolic or hormonal parameters in the PCOS group. However, a weak positive correlation with prolactin was observed in the control group (r = 0.264, p = 0.030). Although vasorin is involved in inflammatory and oxidative-stress pathways, its association with insulin resistance and lipid metabolism remains unclear based on this study. Receiver Operating Characteristic (ROC) curve analysis demonstrated a high diagnostic performance for vasorin in distinguishing PCOS from healthy individuals (AUC = 0.918, p < 0.001, 95% CI: 0.869-0.967). The optimal cutoff value for vasorin (1.285 pg/mL) yielded 92.6% sensitivity and 87.0% specificity. Conclusions: These findings suggest that vasorin may serve as a promising biomarker for PCOS, potentially linking hormonal dysregulation, inflammatory responses, and ovarian dysfunction. However, further validation is required through longitudinal studies, multi-center cohorts, and mechanistic investigations. Additionally, comparative assessments with established biomarkers such as anti-M & uuml;llerian hormone (AMH) and androgen levels are warranted to determine vasorin's diagnostic and prognostic utility in clinical practice.Öğe Exploring the Inflammatory Basis of Endometrial Polyps: Clinical Implications of Hematological Biomarkers in a Retrospective Study(Mdpi, 2025) Keyif, Betul; Yavuzcan, Ali; Yurtcu, Engin; Basbug, Alper; Duzenli, Fatmanur; Keyif, Elif; Goynumer, Fikret GokhanBackground/Objectives: Endometrial polyps (EPs) are common benign endometrial lesions often linked to abnormal uterine bleeding and infertility. While hormonal factors play a key role in their development, recent studies suggest a potential inflammatory component. This retrospective study aimed to assess systemic inflammatory markers, including mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), in EP patients. Methods: A total of 180 patients were classified into three groups: EP (n = 60), chronic endometritis (n = 60), and control (n = 60). Preoperative hematological parameters were retrieved from medical records. Group comparisons were performed using one-way ANOVA, with Tukey's post hoc test applied when significant. Multinomial logistic regression was used to identify independent predictors of EPs. Results: MPV and PLR were significantly higher in the EP group compared to other groups (p = 0.014 and p = 0.015, respectively), while NLR differences were not statistically significant (p = 0.086). Logistic regression identified MPV (p = 0.004) and PLR (p = 0.045) as independent predictors of EPs. Conclusions: These findings suggest that systemic inflammation may contribute to EP development, with MPV and PLR serving as potential inflammatory biomarkers. Further prospective studies with histopathological validation are needed to clarify the role of inflammation in EP pathogenesis.Öğe Implementation of enhanced recovery in women undergoing cesarean delivery improves breastfeeding and maternal perioperative outcomes(Georg Thieme Verlag Kg, 2025) Birden, Duygu Yildiz; Basbug, Alper; Yurtcu, Engin; Kale, IbrahimObjective The study aimed to evaluate delivery outcomes after implementation of the Enhanced Recovery After Surgery (ERAS) protocol in patients delivered by cesarean section (CD). Materials and Methods This randomized controlled prospective study was conducted on 78 pregnant women who underwent CD with the ERAS protocol and 78 pregnant women who under went standard perioperative care. We compared the time to first flatus, visual pain score (VAS), the success of breastfeeding, time to initiation of breastfeeding, time to return to daily activities, hemoglobin values, the incidence of postoperative nausea and vomiting, hospital readmission rates, postoperative wound infection rates, incidence of postpartum blues, and the need for blood transfusion between two groups. Results Time to first flatus, VAS score, time to initiation of breastfeeding, and time to return to activities of daily living were significantly lower in the ERAS group (p<0.001 for all). The rate of successful breastfeeding was significantly higher in the ERAS group (p<0.001). Both groups were similar in terms of other parameters. Conclusion Implementation of ERAS after CD shortens the breastfeeding initiation time and increases rates of successful breastfeeding. ERAS protocols implemented in CD improve perioperative outcomes such as visual pain score and time to resume daily activities.Öğe In vitro maturation with letrozole priming: Can it be a solution for patients with cancerophobia? A pilot study(Galenos Yayincilik, 2020) Hatirnaz, Safak; Hatirnaz, Ebru Saynur; Basbug, Alper; Pektas, Mine Kanat; Erol, Onur; Dahan, Michael; Tan, SeangObjective: To investigate whether letrozole priming could be used efficiently in patients undergoing in vitro maturation (IVM) as compared with follicle-stimulating hormone (FSH) priming. Materials and Methods: This is a retrospective analysis of 63 patients who underwent IVM due to the high risk of Ovarian Hyperstimulation syndrome (OHSS) (n=39), cancerophobia (n=16), and desire for IVM after failed in vitro fertilization attempts (n=8). Forty-two patients received FSH priming and 21 patients received letrozole priming. Results: The patients who had FSH or letrozole priming were statistically similar with respect to age, body mass index, duration of infertility, basal antral follicle count, serum anti-Mullerian hormone levels, and IVM indications (p>0.05 for all). When compared with the FSH priming group, the number of germinal vesicle oocytes, metaphase 11 and fertilized oocytes were significantly higher (p=0.003, p=0.001, and p=0.016, respectively), but the number of metaphase I oocytes was significantly lower in the letrozole priming group (p=0.002). The patients who received FSH and letrozole priming had statistically similar rates of implantation (33.3% vs 37.0%, p=0.709), clinical pregnancy (31.5% vs 33.3%, p=0.848), twinning (1.9% vs 3.7%, p=0.611), and live birth (24.1% vs 29.6%, p=0.682). Conclusion: Potential indications for IVM include patients with increased risk for OHSS and contraindication for hyperestrogenism. Aromatase inhibitors can be used to preserve the fertility of patients with estrogen-sensitive cancers. Letrozole priming appears to be an efficient approach in patients who undergo IVM, with likely less cost than FSH priming.Öğe Iron deficiency anemia in adolescent pregnancy: investigation of its effects and the related factors(Yusuf Haydar ERTEKİN, 2018) Basbug, Alper; Sonmez, Cemil İsikIntroduction: Adolescent pregnancies and their maternal and fetal complications are a global health burden. Iron deficiency anemia is among the factors, which might contribute to these negative consequences. In this study, we aimed to evaluate the frequency of iron deficiency anemia among pregnant adolescents followed at the Düzce University Medical Faculty Hospital and to investigate its maternal and fetal effects. Methods: A total of 122 pregnant women under 19 years of age were included in this case-control study. The socio-economic characteristics, hematological status, and adverse maternal and perinatal outcomes possibly related to iron deficiency anemia were evaluated.Results: The incidence of anemia among the studied women was 29.5%, and 56.5% were receiving iron supplementation. Oral iron supplementation rate was 33.3% in the anemic group and 66.2% in the non-anemic group (p = 0.01). While the serum ferritin and hemoglobin levels were lower in the anemic group, iron binding capacity was lower in the non-anemic group, and the difference between the groups was statistically significant (p = 0.01, p = 0.01, and p = 0.02; respectively). Concerning adverse perinatal outcomes, preeclampsia was seen in 11.4% of the anemic group and 4.6% in the non-anemic group; the difference was statistically significant (p = 0.01). Conclusions: Iron deficiency anemia is a common problem in adolescent pregnancy. However, many anemic pregnant adolescents do not receive iron treatment. Positive effects on some maternal and perinatal outcomes can be achieved by administering iron supplementation to these women. Iron use should be increased to combat iron deficiency anemia during pregnancy.Öğe Long-term obstetric, perinatal, and surgical complications in singleton pregnancies following previous cesarean myomectomy: a retrospective multicentric study(Frontiers Media Sa, 2024) Guler, Oguz; Hatirnaz, Safak; Sparic, Radmila; Basbug, Alper; Erol, Onur; Kalkan, Uzeyir; Ulubasoglu, HasanObjectives The safety of cesarean myomectomy has been proven by previous studies. Our study aimed to reveal the long-term perinatal, obstetric, and surgical outcomes of cesarean myomectomy (CM) by comparing different CM techniques. Material and methods This retrospective multicentric case-control study involved 7 hospitals and included 226 singleton pregnancies that underwent repeated cesarean section (CS) between 2015 and 2020. Among these pregnancies, 113 of 226 cases had CM (Group A), and 113 had only CS (Group B). Of the 113 cases in which CM was performed, 58 underwent endometrial myomectomy (EM) (Subgroup A1) and 55 underwent serosal myomectomy (SM) (Subgroup A2). The groups were compared in terms of obstetric, perinatal, and surgical outcomes, and fibroid recurrence, myomectomy scar healing rate, and adhesion formation were noted. Results There was no significant difference between the groups in terms of maternal age, body mass index, gravidity, parity, and fibroid diameter in previous CS (p > 0.05). In the perinatal and obstetric evaluation of the groups, there was no significant difference between the groups in terms of neonatal weight, Apgar score, fetal growth restriction, preterm premature rupture of membranes, preterm delivery, hypertension in pregnancy, and diabetes mellitus (p > 0.05). The fibroid recurrence rate was 28.3%, and the myomectomy scar good healing rate was 99.1%. There was no difference between the groups in terms of CS duration, preoperative and postoperative hemoglobin levels, perioperative blood transfusion rates, febrile morbidity, and prolonged hospitalization (p > 0.05). In terms of adhesion formation, although the adhesion rate of the SM group was higher than that of the EM group, no statistically significant difference was detected between the groups. Conclusion This study showed that in pregnancies following CM, obstetrical, perinatal, and surgical outcomes were unaffected. Obstetricians can safely use CM, either the trans-endometrial or serosal technique, as it is a safe and effective method with long-term results.Öğe McDonald versus modified Shirodkar rescue cerclage in women with prolapsed fetal membranes(Taylor & Francis Ltd, 2020) Basbug, Alper; Bayrak, Mehmet; Dogan, Ozan; Kaya, Aski Ellibes; Goynumer, GokhanPurpose: We compared the efficacy of modified Shirodkar and McDonald rescue cerclage techniques in women with singleton pregnancies. Methods: The study sample included 47 women who presented at two tertiary hospitals in Turkey from 2008 to 2017 and underwent rescue cerclage due to cervical incompetence and cervical dilatation with fetal membranes prolapsed into the vagina. The outcomes were compared by cerclage technique used, Shirodkar or McDonald. Results: The McDonald cerclage was applied in 27 cases, and modified Shirodkar cerclage in 20 cases. A longer cerclage-to-birth interval (83.8 +/- 37.6 vs. 63.7 +/- 38.9 days) and later gestational age at delivery (33 vs. 31 weeks) were observed with the Shirodkar cerclage, although these differences were not statistically significant (p = .08 and .63, respectively). Both groups had similar delivery rates after 28, 32, and 37 weeks (p = .20, .15, and .25, respectively), whereas the modified Shirodkar technique resulted in a higher rate of live births although these differences were not statistically significant (85% vs. 63%, p = .09). Conclusion: The effects of the McDonald and modified Shirodkar cerclage procedures on prolonging pregnancy and improving the live birth rate were similar. Therefore, either technique can be applied to prevent neonatal loss due to advanced prematurity.Öğe Morbidly adherent placenta and cesarean section methods. A retrospective comparative multicentric study on two different skin and uterine incision(Via Medica, 2021) Soyer-Caliskan, Canan; Celik, Samettin; Basbug, Alper; Hatirnaz, Safak; Guclu, Mehmet; Akbaba, Eren; Tinelli, AndreaObjectives: Morbidly adherent placenta (MAP) is one of leading causes of maternal mortality, with an increasing rate because of repeated cesarean sections (CS). The primary objective of this study is to compare two techniques of skin and uterine incisions in patients with MAP, evaluating the maternal fetal impact of the two methods. Retrospective multicentric cohort study. Material and methods: A total of 116 women with MAP diagnosis were enrolled and divided in two groups. Group one, comprised of 81 patients, abdominal entry was performed by Pfannenstiel skin incision plus an upper transverse lower uterine segment (LUS) incision (transverse-transverse), which was 2-3 cm above the MAP border, with the uterus in the abdomen. In group two, comprised of 35 patients, abdominal entry was performed by an infra-umbilical midline abdominal incision, by vertical-vertical technique, and the pregnant uterus was incised by a midline incision (vertical) from the fundus till the border of the MAP. Total surgery time, blood loss, blood product consumption, total hospital stay, cosmetic outcomes, and postoperative complications were investigated. Results: Total time of surgery was significantly shorter in group 1 (p < 0.05). Intraoperative blood loss was higher in group 2. Difference between preoperative and postoperative Hb and Htc levels were 3.30 +/- 1.04 and 12.99 +/- 5.07 respectively (p = 0.012; p = 0.033). The use of erythrocyte suspension (ES), fresh frozen plasma (FFP), and cryoprecipitate and thrombocyte suspension (TS) were found to be significantly lower in patients of group 1than vertical-vertical group (p = 0.008, p = 0.009, p = 0.001, p = 0.001, respectively). There was no difference in terms of total length of hospital stay between groups. Conclusions: In a subgroup of patients diagnosed for MAP, the transverse-transverse incision resulted in less bleeding, less blood and blood product use, and had better cosmetic results than vertical-vertical incision. Moreover, the total time of surgery, crucial for MAP patients, seems to be shorter also in transverse-transverse incision than in vertical-vertical incision.Öğe Predictive Value of Intrapartum Transperineal Ultrasonography in Determining Delivery Mode: A Prospective Study(Duzce Univ, Fac Medicine, 2025) Teberik, Ceren; Keyif, Betul; Yurtcu, Engin; Basbug, Alper; Goynumer, Fikret GokhanObjective: This study aimed to evaluate the usefulness of intrapartum transperineal ultrasonographic (ITU) parameters in predicting delivery mode. Method: This prospective study included 104 pregnant women inAactive labor with ruptured membranes at D & uuml;zce University Health Application and Research Center from April 2023 to April 2024. ITU measured the angle of progression (AoP), head-perineum distance (HPD), and midline angle (MLA). These parameters were compared with digital vaginal examinations and delivery outcomes. Results: Of the participants, 93 (89.4%) had spontaneous vaginal deliveries (SVD), 6 (5.7%) had operative vaginal deliveries (OVD), and 5 (4.8%) had cesarean sections (C/S). AoP1 and AoP2 were significantly higher in the SVD group compared to OVD and C/S groups (p<0.001). The Delta AoP was significantly lower in the OVD group (p=0.044). HPD1 and HPD2 were significantly higher in the C/S group (p=0.031 and p=0.041, Arespectively). MLA1 and MLA2 were significantly lower in the SVD group (p=0.002 and p=0.001, Arespectively). Conclusions: ITU is a valuable tool in predicting delivery mode. AoP, HPD, and MLA measurements provide objective and reliable data to assist clinicians in labor management. Further research with larger sample sizes is needed to validate these findings and establish standardized protocols for clinical use.Öğe Predictive Value of Volumetric Measurements of Fetal Adrenal Glands for Preterm Birth: A Case-Control Study(Imr Press, 2024) Basbug, Alper; Yurtcu, Engin; Keyif, Betul; Kaya, Aski Ellibes; Sungur, Mehmet Ali; Goynumer, Fikret Gokhan; Hatirnaz, SafakBackground: To investigate whether fetal adrenal gland volume (AGV) and fetal zone volume (FZV), important components of the fetal adrenal gland, differ between women who have term and preterm births, and to determine whether these two parameters can be used to predict premature birth. Methods: A total of 238 pregnant women at 24-28 weeks of gestation were included in this case-control study. The fetal AGV and FZV were ultrasonographically evaluated, and corrected AGV (cAGV) and corrected FZV (cFZV) were assessed with adjustments for estimated birth weight. Receiver operating characteristic (ROC) curves were used to assess the ability of AGV, FZV, cAGV, and cFZV to predict preterm birth. Results: Ultrasound exams on 220 term fetuses and 18 preterm fetuses showed that preterm fetuses exhibited higher AGV (p = 0.039), FZV (p = 0.001), cAGV (p = 0.001), and cFVZ (p = 0.001) compared to term fetuses. Conclusions: These results demonstrated that term and preterm fetuses differ in their AGV and FZV within this study population. The data generated by 3D sonography between 24 and 28 weeks of gestation may be beneficial for predicting premature birth. However, larger prospective studies with a larger sample size of preterm births are needed to validate these findings.Öğe PROOF OF CONCEPT OF A TREATMENT FOR HUMAN OOCYTE MATURATION ARREST;TRANSVAGINAL OVARIAN NEEDLE INJURY PRECEEDING LETROZOLE PRIMING IN VITRO MATURATION(Elsevier Science Inc, 2020) Hatirnaz, Safak; Hatirnaz, Ebru; Basbug, Alper; Dahan, Michael H.; Hatirnaz, Kaan[Abstract Not Available]
