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Öğe Akciğer Kanseri Semptom Taramasının Sigara Bıraktırmadaki Rolü(2022) Balbay, Öner; Kalkanlı, Nevin; Karataş, Naciye; Yeşiloğlu, Reşat; Arbak, Peri Meram; Annakkaya, Ali NihatAmaç: Bu çalışmada Düzce ilinde 30 yaş ve üzeri sigara içenlerde akciğer kanseri semptom taramasının sigara bırakmadaki rolü araştırıldı. Gereç ve Yöntemler: Randomize 700 hane seçilerek 30 yaş üzeri sigara anamnezi olan 500 olgu çalışmaya alındı. Olguların sigara alışkanlıkları ve akciğer kanseri semptomları bir anket formuyla yüz yüze görüşmeyle sorgulandı. Sigaranın akciğer kanseri için önemli bir risk faktörü olduğu vurgulandı. Halen aktif sigara içen 474 olgunun 353'üne 6 ay sonra telefonla sigara alışkanlıkları yeniden sorgulandı. Bulgular: Toplam 353 sigara içen olgunun 32’si (%9,1) kadın, 321’i (%90,9) erkekti. Yaş ortalaması 46±9 olan olguların, ortalama 36±24 paket-yıl sigara anamnezi vardı. 130'u (%36,8) sigarayı bırakmayı düşünüyordu ve 65'i (%18,4) sigarayı bırakmayı denemişti. 6 ay sonraki kontrolde 17 olgu (%4,8) sigarayı bırakmış, 59 olgu (%16) sigarayı azaltmış, 2 olgu (%0,6) ise artırmıştı. Sigarayı bırakanların hiçbiri ilk görüşmede bırakmayı düşündüğünü söyleyenler veya daha önce bırakmayı deneyenlerden değildi. Sigarayı bırakanların yaş ortalaması sigara içmeye devam edenlere göre daha yüksekti (p=0,044) ve sigarayı bırakanların daha uzun süredir sigara içme öyküleri vardı (p=0,001). Hemoptizi ve çomak parmak semptomlarının varlığı sigara bırakma oranlarını anlamlı düzeyde artırmaktaydı (sırasıyla p=0,048, p=0,013). Bu çalışmada akciğer kanseri semptom sorgulamasından 6 ay sonraki sigara bırakma oranı (%4,8), kendiliğinden sigarayı bırakma oranından (%1) anlamlı düzeyde yüksekti (p=0,001). Sonuç: Akciğer kanseri semptom taramasıyla sigara bırakma oranları artırılabilir. Sigara bırakma poliklinikleri yanında bu tip yaklaşımlar sigara mücadelesine katkıda bulunabilir.Öğe Association between varicocele and chronic obstructive pulmonary disease(John Wiley & Sons Inc, 2006) Erdoğmuş, Beşir; Yazıcı, Burhan; Balbay, Öner; Annakkaya, Ali Nihat; Özdere, Betül Ayça; Bulut, İsmetPurpose. To evaluate the relationship between varicocele and chronic obstructive pulmonary disease (COPD) via color duplex sonography. Materials and Methods. Forty-four male patients with COPD (age range, 50-89 years; mean +/- SD, 66 +/- 9) and 44 male healthy controls (age range, 47-75 years; mean +/- SD, 65 +/- 6) were evaluated with color duplex sonography for unilateral or bilateral varicocele. Results. The incidence of right, left, and bilateral varicocele was 47.7%, 65.9%, and 38.6% respectively, in the COPD group, versus 22.7%, 52.3%, and 13.6% in the control group. The incidence of right and bilateral varicocele in the COPD group was significantly higher than in the control group (p < 0.05). The incidence of varicocele also increased with increase in COPD severity. Conclusions. The incidence of varicocele in COPD patients is high. Varicocele might be one of the most important causes of scrotal pain and infertility in COPED patients. (C) 2006 Wiley Periodicals, Inc.Öğe An atypical neurofibroma in the posterior mediastinum: A case report(2011) Karapolat, Sami; Gezer, Suat; Yıldırım, Ümran; Dumlu, Talha; Balbay, Öner; Kandiş, Hayati; Özaydın, İsmetNerve sheath tumors such as neurofibroma, schwannoma, and perineurioma are relatively uncommon lesions that sometimes constitute an interesting diagnostic and therapeutic problem in the clinical practice. A 27-year-old male patient was operated for a mass located in the left posterior mediastinum. The mass was resected by a thoracotomy, and a diagnosis of atypical neurofibroma was revealed histopathologically. He has been well without any problems in his 6 months postoperative period. Intrathoracic neurogenic tumors should be resected surgically due to the possibility of malignancy. Complete resection can be performed safely by a thoracotomy approach and is necessary for achieving a cure. © 2011 Düzce Medical Journal.Öğe Deprem İlişkili Akciğer Hastalıkları; Yayınların Bibliyometrik Analizi(2024) Balbay, Ege Güleç; Kurutkan, Mehmet Nurullah; Gülhan, Pınar Yıldız; Balbay, ÖnerAmaç: Depreme bağlı akciğer hastalıkları (DİAH), afetin hem doğrudan hem de dolaylı sonucu olarak görülebilmektedir. Depremlerde yıkılan binalardan çıkan toz ve partiküllerin solunması, deprem sonrası oluşabilecek tsunami nedeniyle su ve patojenlerin aspirasyonu, pulmoner tromboembolizm, bulaşıcı solunum yolu hastalıkları ve göğüs travmaları gibi birçok DİAH gelişebilir. Bu bibliyometrik incelemenin amacı, DİAH yayınlarının entelektüel yapısını keşfetmektir. Gereç ve Yöntemler: DİAH alanıyla ilgili veri tabanları için bir arama stratejisi geliştirilmiştir. Web of Science veri tabanında 334 makaleye ulaşılmıştır. Tam metin okumaları sonucunda kalan 152 makale bibliyometrik yazılım ile atıf ve ortak atıf analizine tabi tutulmuştur. Bu araştırmaya ek olarak, alanın entelektüel yapısını incelemek için küme analizine dayalı metodolojiler kullanılmıştır. Bulgular: Yayınların yapıldığı zaman dilimine bakıldığında ilk yayının 1996 yılında yayınlandığı görülmektedir. İlk üç yazar incelendiğinde Yanai 6 yayın, Ueda 6 yayın ve Kobayashi 5 yayın ile sıralamayı paylaşıyor. Aynı zamanda bir deprem ülkesi olan Japonya 50 yayınla ilk sırada yer alıyor. Üç ana küme belirlenmiş olup, bu kümeler, “göğüs travmaları: tipleri, sıklıkları ve tıbbi müdahale stratejileri”, “depreme hazırlıklı olma ve depreme müdahale kapasitesi” ve “solunum yolu enfeksiyonları ve depremdir”. Sonuç: Bu araştırma, DİAH alanındaki depremler konusunda en etkili dergileri, yazarları ve ülkeleri belirlemenin yanı sıra, bu alandaki baskın araştırma temalarını da belirlemiştir. Araştırmamız DİAH alanını özetlemekte, gelecekteki araştırmalar için bir gündem sağlamakta ve deprem ile akciğer hastalıkları arasındaki ilişkinin daha derinlemesine çalışılmasına katkıda bulunmaktadır.Öğe Effect of Resveratrol in Acute Hypoxic Pulmonary Vasoconstriction in Isolated Lamb Pulmonary Arteries and Veins(Kafkas Univ, Veteriner Fakultesi Dergisi, 2009) Sılan, Coşkun; Kuşcuoğlu, Evren; Uzun, Özge; Balbay, ÖnerResveratrol (RSV) is a natural phytoalexin with many biological effects, including antioxidant, anti-platelet, anti-atherogenic, anti-inflamatory, estrogenic properties, immunomodulation and chemoprevention. In the cardiovascular system, it has been shown to cause relaxation of vascular smooth muscle, and reports indicate that RSV induces vasodilatory effects in several vascular beds by acting in endothelium dependent and independent manners. The aim of the study was to determine the role of RSV on hypoxia induced vasoconstriction in precontracted isolated pulmonary arteries and veins. Isolated lamb pulmonary vessels were suspended in an organ bath filled with Krebs Heinseleit solution and isolated contractions were recorded continuously via an isometric transducer connected to a computerized polygraph system. The solution was aerated with room air or a gas mixture of 95% N-2 + 5% CO2 (hypoxic). The oxygen concentration of the bathing medium was measured using an oxygen electrode. Serotonin (5-HT)(10(-5) M) for arteries and U46619, a thromboxane analog (TXA2) for veins, were used as pre contractile agents. Our results showed that in the presence of RSV (20 mu M), hypoxia induced pulmonary vasoconstriction decreased in pulmonary veins pre contracted with U46619, but not in pulmonary arteries pre contracted with 5-HT.Öğe Effect of resveratrol in acute hypoxic pulmonary vasoconstriction in isolated lamb pulmonary arteries and veins(2009) Sılan, Coşkun; Kuşcuoğlu, Evren; Uzun, Özge; Balbay, ÖnerResveratrol (RSV) is a natural phytoalexin with many biological effects, including antioxidant, anti- platelet, anti- atherogenic, anti- inflamatory, estrogenic properties, immunomodulation and chemoprevention. In the cardiovascular system, it has been shown to cause relaxation of vascular smooth muscle, and reports indicate that RSV induces vasodilatory effects in several vascular beds by acting in endothelium dependent and independent manners. The aim of the study was to determine the role of RSV on hypoxia induced vasoconstriction in precontracted isolated pulmonary arteries and veins. Isolated lamb pulmonary vessels were suspended in an organ bath filled with Krebs Heinseleit solution and isolated contractions were recorded continuously via an isometric transducer connected to a computerized polygraph system. The solution was aerated with room air or a gas mixture of 95% N2 + 5% CO2 (hypoxic). The oxygen concentration of the bathing medium was measured using an oxygen electrode. Serotonin (5-HT)(10-5 M) for arteries and U46619, a thromboxane analog (TXA2) for veins, were used as pre contractile agents. Our results showed that in the presence of RSV (20 ?M), hypoxia induced pulmonary vasoconstriction decreased in pulmonary veins pre contracted with U46619, but not in pulmonary arteries pre contracted with 5-HT.Öğe Noninvasive Mechanical Ventilation in Acute Hypoxemic Respiratory Failure(2019) Balbay, ÖnerNoninvasive mechanical ventilation is widely used for acute respiratory failure in a variety ofetiologies. The recommended specific conditions were the exacerbation of chronic obstructivepulmonary disease, cardiogenic pulmonary edema, de novo acute hypoxemic respiratoryfailure, immunocompromized pneumonia, palliation, postoperative period, weaning andpostextubation. Pneumonia and acute respiratory distress syndrome are common causes ofacute hypoxemic respiratory failure. Noninvasive mechanical ventilation failure is high in thisdisease group compared to acute hypercapnic respiratory failure. Noninvasive mechanicalventilation can be recommended in patients with mild even in moderate acute respiratorydistress syndrome and not in patients with severe acute respiratory distress syndrome. Due toinsufficient evidence in patients with pneumonia and acute respiratory distress syndrome, norecommendation can be given for routine use of noninvasive mechanical ventilation. Althoughsome patients benefit from noninvasive mechanical ventilation, they should be used by a teamexperienced on noninvasive mechanical ventilation in pneumonia and early acute respiratorydistress syndrome. A skilled team, proper place, patient and devices can optimize prognosis.There should be a particular attention to shock, multiorgan failure and change ofconsciousness. Patient selection should be made correctly, considering that mortality can beseen in case of delayed intubation.Öğe Relationship between Diagnosis Period and Internal and External Air Quality in Patients with Tuberculosis(2020) Gülhan, Pınar Yıldız; Elverişli, Mehmet Fatih; Erçelik, Merve; Aytekin, Fuat; Balbay, Öner; Arbak, PeriObjective: The aim of this study was to investigate the relationship between bacteriological case definitionsand indoor and outdoor air quality parameters in tuberculosis (TB).Materials and Methods: A total of 200 patients with TB diagnosed and treated in our hospital during 2012-2018 were included to this study. The air monitoring measurement parameters of the National Air QualityNetwork [particulate matter 10 (PM10), sulfur dioxide (SO2), air temperature, air pressure, and relativehumidity] for the same time period were obtained from the web page http://laboratory.cevre.gov.tr/Default.ltr.aspx.Results: Of the 200 patients, 62.5% (125) were males and 37.5% (75) were females. The rate of diagnosisbased on culture and smear positivity was 48.4% (31), which was significantly higher than that in the clinic[10.9% (7)] among patients who used stove for warming. The rate of diagnosis based on culture and smearpositivity [52.1% (25)] was significantly higher than that in the clinic [8.3% (4)] among patients who were exposed to biomass. The univariate analysis revealed no significant independent effect of warming and biomassuse on case definition. According to the case definitions, the mean values of PM10, SO2, and temperature inthe diagnosed month showed no statistically significant difference. The humidity level in the month was significantly higher, during which cases diagnosed using smear and culture positivity were compared with casesdiagnosed using only culture positivity (p=0.023).Conclusion: This study indicates that biomass used as a cooking fuel is a risk factor for pulmonary TB, implying that TB occurrence can be reduced significantly by lowering or preventing the exposure to cookingsmoke emitted from biomass fuel.Öğe Respiratory symptoms and peak expiratory flow rates among furniture-decoration students(Inst Agricultural Medicine, 2004) Arbak, Peri Meram; Bilgin, Cahit; Balbay, Öner; Yeşildal, Nuray; Annakkaya, Ali Nihat; Ülger, FüsunThis study was designed to evaluate the effects of furniture production, mainly including fir tree (aberia mulleriana), on respiratory health of young workers and to compare the results with those obtained from previous Studies. Sixty-four furniture-decoration students (57 males and 7 females) and 62 controls (54 male, 8 female) from different departments in the same school were included into the Study. All participants were assessed with a questionnaire (concerning history of occupational exposure, work-related respiratory and other symptoms, smoking history, previous asthma history), full physical examination, spirometric evaluation and chest radiograph. Participants then performed serial monitoring of peak expiratory flow rates (PEER) at work and away from work within a month. Mean age of students was 20.9 +/- 3.7 years, 20.5 +/- 2.6 years in controls. There was no difference between study and control groups with regard to age, gender, smoking status and previous asthma history. Reported cough (23.4% vs. 8.1%) and shortness of breath (18.8% vs. 6.5%) were significantly higher in furniture-decoration students than in controls (p = 0.016 and p = 0.034, respectively). Furniture-decoration students had higher conjunctivitis (34.4% vs. 9.7%, p = 0.001) and rhinitis (34.4% vs. 19.4%, p = 0.044) history when compared with controls. Both students and controls were normal in terms of respiratory examination. PEF recordings were performed for approximately one month. Diurnal variability greater than 20% was seen in 12/64 (18.7%) of students at work, whereas it was detected in 4/62 (6.4%) of controls (p = 0,034). When comparing for the presence of diurnal variability greater than 20% in weekends, no difference was found between groups (p = 0.457). In conclusion, early detection of work-related respiratory changes by serial monitoring of peak expiratory flows should save the workers from hazardous respiratory effects of the furniture production, especially in young population.
