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Öğe Anemia as a risk factor for low bone mineral density in postmenopausal Turkish women(Elsevier Science Bv, 2012) Korkmaz, Uğur; Korkmaz, Nurdan; Yazıcı, Selma; Erkan, Melih; Baki, Ali Erdem; Yazıcı, Mehmet; Ataoğlu, SafinazBackground: We investigated the association of bone mineral density (BMD) by detected dual-energy X-ray absorptiometric (DXA) method and hemoglobin (Hb) levels in a large sample. Methods: The current study enrolled 371 postmenopausal women (82 anemic patients), who were screened for osteopenia or osteoporosis by DXA. Patients with osteopenia or osteoporosis (T score < -1.0 SD) were grouped as having low bone mass (LBM). Results: Anemic patients were older and had significantly higher duration of menopause. When compared with subjects with normal Hb, anemic patients had significant lower femur t score, femur BMD, femur Z score, spinal t score, spinal BMD and spinal Z score (p<0.001). Additionally, the ratio of subjects with LBM in the femur and spine were significantly high in anemic patients (pÖğe Anti-TNF-Alpha Therapy for Concomitant Behçet's Disease and Ankylosing Spondylitis(2012) Özşahin, Mustafa; Turan, Hakan; Ataoğlu, Safinaz; Baki, Ali Erdem; Çelebi, Esra…Öğe Anti-TNF-Alpha Therapy for Concomitant Behcet's Disease and Ankylosing Spondylitis(Turkish League Against Rheumatism, 2012) Özşahin, Mustafa; Turan, Hakan; Ataoğlu, Safinaz; Baki, Ali Erdem; Çelebi, Esra…Öğe Bilateral Fifth-Finger Camptodactyly(Lippincott Williams & Wilkins, 2012) Özşahin, Mustafa; Uslu, Mustafa; Kutlucan, Ali; Baki, Ali Erdem; Ataoğlu, Safinaz…Öğe Echocardiographic Evaluation Of The Left Ventricular Diastolic Functions In Rheumatoid Arthritis(Düzce Üniversitesi, 2010) Bulur, Serkan; Önder, Elif; Ordu, Serkan; Çalık, Yalkın; Baki, Ali Erdem; Ozhan, Hakan; Yazıcı, MehmetBackground and aim: The aim of this study was to evaluate LVDF in patients with RA, analyzing conventional Doppler and tissue Doppler echocardiographic imaging (TDI) which is a new echocardiographic application. Method: Forty-six patients with RA and 31 healthy persons were included in this study. Duration of disease ranged from 0 to 12 years (mean 4,2 ± 4,3 / years). All patients and the control group were evaluated by M-mode, two-dimensional, conventional Doppler echocardiography and TDI. Results: When compared with controls, the RA group showed that basal clinic and echocardiographic parameters, left atrial diameter, left ventricular diameters, left ventricular ejection fraction, left ventricular wall thicknesses of these two groups were similar. Among conventional Doppler transvalvular mitral flow parameters, early diastolic flow velocity (E) (p = 0,001), late diastolic flow velocity (A) (p = 0,03) and deceleration time (p ? 0,001) values were higher in patients with RA than that in the control group. E/A ratio was found to be lower in patients with RA than that in the control group (p ? 0,001). Mitral annular early diastolic velocity, among TDI parameters, was found to be lower in patients with RA than that in the control group (p = 0,01). Mitral annular late diastolic velocity was also found to be higher in RA patients (p = 0,007). Conclusion: A comparison between age and sex of RA patients and healthy individuals revealed that left ventricular conventional Doppler and TDI parameters of RA patients were impairedÖğe The effect of breast-feeding duration on bone mineral density in postmenopausal Turkish women: a population-based study(Termedia Publishing House Ltd, 2011) Yazıcı, Selma; Korkmaz, Uğur; Erkan, Melih; Korkmaz, Nurdan; Baki, Ali Erdem; Alçelik, Aytekin; Ataoğlu, SafinazIntroduction: In the present study, we investigated the effects of breast-feeding time on bone mineral density (BMD) later in life. Material and methods: The current study was based on a retrospective analysis of 586 postmenopausal women with a mean age of 60.8 years, who were screened for osteoporosis by dual energy X-ray absorptiometry (DXA). They were classified into 4 groups with respect to the duration of their breast-feeding as never (group 1), 1-24 months (group 2), 25-60 months (group 3), or > 60 months (group 4). Bone mineral density results for the femur neck and lumbar spine were classified into 3 groups according to WHO criteria as normal (T score > -1.0 SD), osteopenia (T score -1.0 to -2.5 SD), and osteoporosis (T score < -2.5 SD). Patients with osteopenia or osteoporosis (T score < -1.0 SD) were considered as having low bone mass (LBM). Results: We found a correlation between duration of lactation and femur BMD or spine BMD in the study population (r = 0.116, p < 0.005; r = -0.151, p = 0.001, respectively). Significant differences were found between femur BMD and spine BMD of groups in one-way ANOVA analysis (p = 0.025, p = 0.005, respectively). Additionally, when compared with the other three groups, group 4 was older and had longer duration of menopause (p < 0.01). In logistic regression analysis, age and body mass index were found as independent risk factors of LBM [odds ratio: 1.084 (95% CI 1.031-1.141); odds ratio: 0.896 (95% CI 0.859-0.935)], while duration of lactation was not found as an independent predictor of LBM. Conclusions: In this study, we have found that changes of bone metabolism during lactation had no effect on postmenopausal BMD measured by DXA. Consequently, it can be suggested that long breast-feeding duration is not a risk factor for low bone mass later in life.Öğe The effect of osteoporosis on self-report sleep quality in postmenopausal women(Wiley-Blackwell, 2011) Yazıcı, Selma; Canan, Fatih; Baki, Ali Erdem; Erkan, Melih Engin; Ataoğlu, Safinaz; Ataoğlu, AhmetWe aimed to show the effect of osteoporosis on sleep quality in 59 postmenopausal women. The participants' bone-mineral density levels were measured by dual-energy X-ray absorptiometry (DEXA). According to their DEXA results, participants were divided into two groups as osteoporotics and controls. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality. Fourteen osteoporotic women (43.8%) and four controls (14.8%) were "poor" sleepers (p < 0.05). Postmenopausal women with osteoporosis scored greater on the "sleep latency" and "sleep duration" components of PSQI than controls. According to the findings of our study, osteoporosis is a risk factor for poor sleep quality in postmenopausal women.Öğe The effect of parity on bone mineral density in postmenopausal turkish women [Postmenapozal kadinlarda do?um sayisinin kemi?k mi?neral yo?unlu?u üzeri?ne etki?si?](2010) Baş, Ersun; Yazıcı, Selma; Baki, Ali Erdem; Çalık, Yalkın; Yavuz, Metin; Önder, Elif; Ataoğlu, SafinazA lot features, belonging to reproductive periods of women can affect the development of osteoporosis. We have aimed to search whether one of the reproductive factors, which is parity, is a risk factor for the progression of postmenopausal osteoporosis or not. This research has been realized on 328 postmenopausal women who have applied to Physical Medicine and Rehabilitation Polyclinic. Patients, who have secondary osteoporosis and risk factors, have not been included in this research. The patients have been categorized into 4 groups, such as patients who have never given birth, given birth once and twice, three and four times, five times and over. Bone mineral density of the patients have been examined from femoral neck and lomber vertebrae region (L1-L4). As a result of statistical analysis, a negative correlation has been found both in bone mineral density of femoral neck and lomber vertebrae with parity (p=0.002, p=0.010, respectively). When the patients are examined according to their age group, a significant relation has been found between parity and bone mineral density only in 50-60 age group. A significant relation has not been found between parity and osteoporotic fracture. It has been found that increased parity is a factor, decreasing the bone mineral density. We have concluded that the early detection and treatment of osteoporosis can be realized with the search of the parity, while the risk factors for osteoporosis are being examined on women who are in postmenopausal period. Finally, it has been concluded that since many different results have been concluded from this subject, new studies must be done so as to enlighten this subject.Öğe Hemophagocytic Syndrome in a Patient with Adult-onset Still's Disease(Turkish League Against Rheumatism, 2011) Çalık, Yalkın; Ataoğlu, Safinaz; Baş, Ersun; Yazıcı, Selma; Baki, Ali Erdem; Yavuz, MetinHemophagocytic syndrome is a fatal and life-threatening syndrome characterized by pancytopenia and multiple organ failure. It can frequently be seen in childhood as a primary or familial condition. In adults, it occurs secondarily. In etiology, wide range of factors are related to this syndrome. Adult-onset Still's disease seems to be one of the systemic rheumatological diseases that cause this syndrome. In our literature review, we found few studies related to this syndrome. In this article, we report a 40-year-old female patient who had been treated with the diagnosis of Adult-onset Still's disease for four years in our clinic and who developed hemophagocytic syndrome during her follow-ups.Öğe Impact of osteoporosis on the patients' quality of life in men(2010) Çalık, Yalkın; Yazıcı, Selma; Baki, Ali Erdem; Baş, Ersun; Yavuz, Metin; Önder, Elif; Ataoğlu, SafinazIn previous studies, it has been shown to be the impact of postmenopausal osteoporosis on the patients'quality of life (QOL). The aim of this study was to investigate relationship between osteoporosis and QOL in men with osteoporosis. The study population consisted of 113 men who had osteoporosis and 67 healthy men as control group. Bone mineral density (BMD) was measured by using Dual-Energy X-Ray Absorptiometry (DEXA). The assessment of QOL was carried out using the Short Form 36 (SF- 36) and European Foundation for Osteoporosis (QUALEFFO) scales. The SF- 36 scores were significantly lower in patients with osteoporosis when comparing with controls (61.8 ± 2.7 and 72.7± 2.2, respectively). However, the QUALEFFO scores were significantly higher in men with osteoporosis (58.0 ± 5.1 and 52.0 ± 2.9, respectively). In correlation analysis, the SF- 36 scores positively correlated with femur BMD and spine BMD values (p=0.004, p=0.001, respectively). Moreover, the QUALEFFO scores positively correlated with spine BMD and femur T scores (p=0.001, p=0.011, respectively). Osteoporosis was strongly correlated with worses in QOL assessed by SF- 36 and QUALEFFO scales in men.Öğe Primer Diz Osteoartritinde İzokinetik Egzersiz, Lazer ve Diklofenak İyontoforezi Uygulamalarının Etkilerinin ve Etkinliklerinin Karşılaştırılması(Düzce Üniversitesi, 2013) Yavuz, Metin; Ataoğlu, Safinaz; Baki, Ali Erdem; Özşahin, MustafaAmaç: Diz osteoartritinin (OA) konservatif tedavisi, farmakolojik tedavi ve farmakolojikolmayan tedavi ana başlıkları altında toplanır. Bu nonfarmokolojik yöntemlerin etkinlikleride yeterince çalışılmamış olmasına rağmen etkileri birbirleriyle hiç karşılaştırılmamıştır. Buçalışmanın amacı da diz OA’lı hastalarda izokinetik egzersiz programı, lazer ve iyontoforezyöntemlerinin ağrı ve fonksiyonel durum üzerine etkileri ve bu etkilerinin birbirlerineüstünlüklerinin olup olmadığını saptamaktır.Materyal ve Metot: Diz OA tanılı, yaşları 40 ile 70 arasında değişen 160 hasta 40’ar kişilikdört gruba randomize edildi. Altı hafta süreyle birinci gruba izokinetik egzersiz, ikinci grubaiyontoforez, üçüncü gruba lazer ve dördüncü gruba (kontrol grubu) psödoiyontoforezuygulandı. Ağrı, hastalık şiddeti, eklem tutukluluğu ve fonksiyonel durumu tedavi öncesi vetedavi sonrası VAS, WOMAC ve Lequesne diz eklem şiddet indeksi ile değerlendirildi.Bulgular: Tedavi sonrası dört grubun da VAS skorlarında (p:0,001) tedavi öncesine göreistatistiksel olarak anlamlı düzeyde azalma saptandı (pÖğe Relationship between blood pressure levels and bone mineral density in postmenopausal Turkish women(Termedia Publishing House Ltd, 2011) Yazıcı, Selma; Yazıcı, Mehmet; Korkmaz, Uğur; Erkan, Melih Engin; Baki, Ali Erdem; Erden, İsmail; Ataoğlu, SafinazIntroduction: We investigated the association between bone mineral density (BMD) detected by dual-energy X-ray absorptiometric (DXA) method and blood pressure (BP) in a large sample of postmenopausal women. Material and methods: The current study was based on a retrospective analysis of 586 postmenopausal women with a mean age of 60.8 +/- 8.8 years, who were screened for osteopenia or osteoporosis by DXA. Patients with hypertension (HT, n = 306) were compared with normotensive (NT, n = 290) individuals. Bone mineral density results for the femur neck and spine were classified into 3 groups according to World Health Organization criteria: normal (T score > -1.0 SD), osteopenia (T score -1.0 to -2.5 SD) and osteoporosis (T score <-2.5 SD). Patients with osteopenia or osteoporosis (T score < -1.0 SD) were grouped as having low bone mass (LBM). Results: There were no significant differences in femur T score, femur BMD, femur Z score, spinal T score, spinal BMD and spinal Z score between hypertensive and normotensive groups. The group of patients with low bone mass calculated from femur T scores had higher age, systolic BP, duration of hypertension and duration of menopause, but lower BMI. Similarly, patients with low spine BMD had higher age and duration of menopause, but lower BMI. Linear regression analysis showed a significant correlation between systolic BP and femur BMD and T score values. Furthermore, logistic regression analysis revealed that hypertension is an independent predictor of spinal osteopenia and osteoporosis. Conclusions: The presence of hypertension is an independent predictor of spinal low bone density in Turkish women after menopause.Öğe Romatoid Artritli Hastalarda Sol Ventrikül Diyastolik Fonksiyonlarının Ekokardiyografik Olarak Değerlendirilmesi(2010) Yazıcı, Selma; Bulur, Serkan; Önder, Elif; Ordu, Serkan; Çalık, Yalkın; Baki, Ali Erdem; Ataoğlu, SafinazGiriş: Bu çalışmamızda geleneksel Doppler ve yeni bir ekokardiyografik teknik olan doku Doppler görüntüleme (DDG) yöntemini kullanarak RA hastalarında sol ventrikül diyastolik fonksiyonlarını değerlendirdik. Yöntem: Çalışmamıza 46 RA hastası ve 31 sağlıklı birey dahil edildi. Hastalık süresi 0 ile 12 yıl arasında idi (ortalama 4,24,3 / yıl). Tüm hastalar ve kontrol grubu M-mode, 2-D, geleneksel Doppler ekokardiyografi ve DDG ile değerlendirildi. Bulgular: Kontrol grubu ile RA grubunda temel klinik ve ekokardiyografik parametreler, sol atriyum çapı, sol ventrikül çapları, sol ventrikül ejeksiyon fraksiyonu, sol ventrikül duvar kalınlıkları her iki grupta benzerdi. Geleneksel Doppler mitral akım parametrelerinden, erken diyastolik akım velositesi (E) (p 0,001), geç diyastolik akım velositesi (A) (p 0,03) ve deselerasyon zamanı (p 0,001) değerleri kontrol grubuna göre RA hastalarında daha yüksekti. Kontrol grubuna göre RA grubunda E/A oranı daha düşük bulundu (p 0,001). DDG parametrelerinden mitral anuler erken diyastolik hız dalgası kontrol grubuna göre RA grubunda daha düşük bulundu (p 0,01). Mitral anuler geç diyastolik hız dalgası ise daha yüksek bulundu (p 0,007). Sonuç: Yaş ve cinsiyet olarak benzer özellikte olan RA hastaları ile kontrol grubu karşılaştırıldığında, RA hastalarında geleneksel Doppler ve doku Doppler parametrelerinin bozuk olduğu saptandı.Öğe Statin tedavilerinin iskelet kası, anksiyete, depresyon ve yaşam kalitesi üzerine etkileri(Düzce Üniversitesi, 2012) Baki, Ali Erdem; Ataoğlu, SafinazHiperlipidemi tedavisinde özellikle de LDL kolesterolün düşürülmesinde en etkili, en yaygın kulanılan Hidroksimetilglutaril-koenzim A inhibitörlerin (statinler)çok sayıda çalışmada koroner arter hastalığında mortalite ve morbiditeyi azalttığı,son çalışmalarda da inmeyi önlemede faydalı olduğu bulunmuştur. Kontrollü klinik çalışmalara göre statinler oldukça iyi tolere edilebilmekle birlikte, miyalji, kramp,güçsüzlük gibi semptomlardan kas kuvvet kaybı, rabdomiyolize kadar ilerleyebilen miyopatiye neden olabilmektedir. Ancak statin tedavisi alan hastalarda müskülerperformansın incelendiği çok az sayıda çalışma vardır.Çalışmamızın amacı iki farklı statin tedavisinin diz izokinetik kas gücü,anksiyete, depresyon, yaşam kalitesi üzerine ve müsküler yan etkilerini araştırmaktır. Hiperkolesterolemi tanılı 63 hasta üç ay süreyle 20 mg/gün atorvastatin ve 20mg/gün rosuvastatin tedavisi almak üzere iki gruba randomize edildi. Tedavi öncesi ve sonrası hastaların dominant dizin izokinetik kas kuvvet ölçümleri yapıldı. Müsküler yan etkiler, serum kreatin kinaz, karaciğer fonksiyon testleri, anksiyete,depresyon ve yaşam kalitesi ölçekleri değerlendirildi.Atorvastatin grubunda %12.5, rosuvastatin grubunda %9.6 oranında müsküler yan etki saptadık. Diz izokinetik kas gücü ölçümlerinde; atorvastatin grubunda 60°/s hızda fleksiyonda ve ekstansiyonda total iş ve 180°/s hızda ekstansiyon pik torkdeğerlerinde, rosuvastatin grubunda ise 60°/s hızda fleksiyonda ve ekstansiyonda total iş değerlerinde istatistiksel anlamlılıkta azalma belirledik. Her iki grupta diz izokinetik kas gücünde azalma saptanan hastaların % 8-10'unda müsküler semptom bulduk. Beck Anksiyete, Beck Depresyon ve Nottingham Sağlık Profili ölçekleri ile değerlendirilen her iki grup hastalarda tedavi öncesi ve tedavi sonrası arasındaistatistiksel anlamlılıkta fark yoktu. Sonuç olarak statin tedavisi alan hastalarda risk faktörleri, müsküler şikayetler ve serum kreatin kinaz yüksekliği olmasa da düzenli kontrollerle kas gücü değerlendirmesi yapılmasının faydalı olacağı bu nedenle statin tedavisi alan hastaların tedavileri başlamadan önce ve tedavileri devam ederken en az üçer aylıkperiyotlarla fiziyatristler tarafından da takip edilmesi gerektiği sonucuna vardık.Öğe The Comparison of Effectiveness of Teriparatide and Alendronate Sodium in Postmenopausal Osteoporosis Treatment(Düzce Üniversitesi, 2013) Büyükkaya, Ramazan; Kaya, Ertuğrul; Baki, Ali Erdem; Aydın, Yusuf; Çelebi, Esra; Ataoğlu, Safinaz; Özşahin, MustafaAim: To evaluate teriparatide and alendronate sodium on bone mineral density ofpostmenopausal women.Materials and methods: Thirty-three postmenopausal women who had been treated withteriparatide and alendronate sodium were evaluated, retrospectively. Patients with a secondaryosteoporosis cause were excluded from the study. Pretreatment and one year after regulartreatment bone mineral density results of lomber vertebra and femur were compared.Results: There wasn’t any statistically difference in femur bone mineral density results betweeneach treatment group. There wasn’t a statistically difference between pretreatment andposttreatment results in both groups, either (p gt;0,05). There was a statistically difference onlomber vertebra bone mineral density results of patients who were treated with teriparatide(p
