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    Can in vitro maturation overcome cycles with repeated oocyte maturation arrest? A classification system for maturation arrest and a cohort study
    (Wiley, 2021) Hatirnaz, Safak; Basbug, Alper; Hatirnaz, Ebru; Tannus, Samer; Hatirnaz, Kaan; Bakay, Kadir; Dahan, Michael H.
    Objective To investigate the role of gonadotropin-stimulated and human chorionic gonadotropin (hCG) -primed in vitro oocyte maturation (IVM) in cases of repeated in vitro fertilization (IVF) failure due to various forms of oocyte maturation arrest (OMA). Methods Retrospective cohort study. Results In all, 63 women with IVF failure due to OMA were evaluated in this study. According to the Hatirnaz & Dahan classification, 11 (17.5%) women were OMA type 1, 22 (34.9%) were OMA type 2, 0 were OMA type 3, 11 (17.5%) were OMA type 4, and 19 women were OMA type 5 (30.1%). Fewer oocytes were retrieved in the IVM than in the IVF cycles. No embryos were produced from oocytes collected in the IVM cycles of women with OMA types 1, 2, and 4. In the OMA type 5 group, 9 (47.4%) day 2 embryos and 6 (31.6%) day 3 embryos were obtained. The difference between the groups was statistically significant (P = 0.001, P = 0.002, respectively). Single day 3 embryo transfer was performed for the six patients with OMA type 5 but no clinical pregnancies occurred. Conclusions Follicle-stimulating hormone-stimulated and hCG-primed IVM does not improve oocyte maturation, developmental potential, or pregnancy rates of women with OMA. Future studies directed to re-establishing normal cytoskeletal architecture and machinery, and resumption of meiosis may be beneficial for obtaining mature oocytes.
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    A Comparative Multicentric Study on Serosal and Endometrial Myomectomy During Cesarean Section: Surgical Outcomes
    (Taylor & Francis Inc, 2021) Hatirnaz, Safak; Guler, Oguz; Basbug, Alper; Cetinkaya, Mehmet Bilge; Kanat-Pektas, Mine; Bakay, Kadir; Kalkan, Uzeyir
    Objective: This multi-center study aims to determine the efficiency and safety of endometrial myomectomy (EM) for the removal of uterine fibroids during cesarean section (CS). Methods: Retrospective review of 360 women diagnosed for fibroids during pregnancy. They all delivered by CS between 2014 and 2019. The study groups included 118 women who only underwent EM, 120 women who only had subserosal myomectomy by traditional technique and 122 women with fibroids who decided to avoid cesarean myomectomy, as control group. They were analyzed and compared the surgical outcomes. Results: The EM, subserosal myomectomy and control groups were statistically (p > 0.05) similar for to age, body mass index (BMI), gravidity, parity, gestational age at delivery, indications for CS, number of excised fibroids, size of the largest myoma. Postoperative hemoglobin values and ? (?) hemoglobin concentrations were lower in SM group (10.39gr/dl vs 9.98 gr/dl vs 10.19 - 1.44 gr/dl vs 1.90 gr/dl vs 1.35; p = 0.047, p = 0.021; respectively) Hybrid fibroids were significantly more frequent in the EM group than subserosal myomectomy and control groups (respectively, 33.1% vs 23.3% vs 27.0%, p = 0.002). Surgery time was significantly longer in the subserosal myomectomy group than EM and control groups (respectively, 46.53 min vs 37.88 min vs 33.86 min, p = 0.001). Myomectomy took significantly longer time in the subserosal myomectomy than EM group (13.75 min vs 8.17 min, p = 0.001). Conclusions: Endometrial myomectomy is a feasible choice for treatment of fibroids during CS, and, basing on our results could be an alternative to traditional cesarean subserosal myomectomy.
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    Fertility preservation in Turkey: a global look for nationwide strategy development
    (2019) Hatırnaz, Şafak; Bakay, Kadir; Hatırnaz, Ebru; Güven, Davut; Başbuğ, Alper; Önder, Sevgen Çelik; Ünlü, Cihat
    As the reproductive technology advanced along with the improved outcome in cancer treatment demands implementing new fertility preservation,developing algorithms on fertility preservation requires tailoring for each society. Here, the authors attempt to modify the current medicalliterature on fertility preservation for the Turkish population. A PubMed search was conducted using the search term fertility preservation. Initially,280 items of literature were accessed. In the second evaluation, 126 articles were examined and 154 items were discarded due to the low qualityof the literature. In the final round, only 68 publications that were the most relevant were found eligible for inclusion in this review article. Inorder to develop a more systematic national guideline, forming a multidisciplinary approach to create a web-based network would be the firststep. Both physicians and patients will have open access to the information. This database should be linked to an international consortium tostay integrated and open for updating. The aim of this review was to evaluate the relationship between the current situation in our country andthe developments in the world in light of the literature, and to establish infrastructure for the development of future approaches in our country.(J Turk Ger Gynecol Assoc 2019; 20: 196-207)
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    Hypogastric artery ligation in laparoscopic hysterectomy: results from a randomized controlled trial
    (Imr Press, 2021) Bakay, Kadir; Yavuzcan, Ali; Kalkan, Üzeyir; Yalçın, İbrahim; Hatırnaz, Şafak; Başbuğ, Alper; Guven, Davut
    Background: Concerning total laparoscopic hysterectomy (TLH), opening the retroperitoneum and prophylactic ligation of both uterine arteries (UA) is not a routine procedure during a simple hysterectomy and it is not practiced widely in gynecology education. Methods: In this study, we tried to show the prophylactic ligation of internal iliac artery anterior division (IIAD) and provide hemostasis of UA at an anatomical plane where we considered it would be easier to perform and relatively safer, in terms of distance, regarding ureteric injury, in a prospective randomized controlled trial. Results: When this technique was used the duration of the operation got longer approximately 3 minutes (min) (57.15 +/- 5.46 vs. 53.66 +/- 8.96 p = 0.018 and p < 0.05), but the amount of bleeding was detected to be at a significantly lower level (73.84 +/- 7.18 vs. 113.96 +/- 21.5 p = 0.001 and p < 0.05). Discussion: In this method, not only we found out that it is easier to ligate IIAD compared to other surgical techniques but also allows for better control of the retroperitoneal area during the procedure therefore minimizing the risk of surgical complications such matically reduced blood loss hence verifying its use in more complex hysterectomies and pelvic lymphadenectomy.
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    Prophylactic ligation of uterine arteries at its origin in laparoscopic surgical staging for endometrial cancer
    (Wiley, 2021) Yavuzcan, Ali; Bakay, Kadir
    Aim The aim of this study was to compare the surgical outcomes between patients who were staged laparoscopically for early-stage endometrioid-type endometrial cancer (EC) between those who underwent prophylactic ligation of uterine arteries (UAs) prior to pelvic lymphadenectomy and the patients who were operated with standard procedure. Methods This retrospective study was conducted in women diagnosed with early-stage and low/intermediate-risk endometrioid-type EC. The control group included patients who underwent standard laparoscopic pelvic lymphadenectomy and the study group concerned patients who underwent prophylactic ligation of UA prior to pelvic lymphadenectomy. The prophylactic ligation of UA procedure was performed at a point just proximal to its origin. Results The mean lymph node count dissected in the study group was higher in terms of statistical significance (17.5 +/- 2.2 vs. 19.8 +/- 3.6, p = 0.003 and p < 0.05). The rate of the patients who had a positive pelvic lymph node detected did not differ between groups (7.4% vs. 16.7%, p = 0.258 and p < 0.05). The operation time (OT) of the patients in the study group did not differ between groups (p = 0.546 and p < 0.05). Hemoglobin drop (-0.5 +/- 0.7) and hematocrite drop (-0.8 +/- 0.9) values in the study group were found to be lower in the study group (p = 0.000, p = 0.000, and p < 0.05). Conclusions Performing prophylactic ligation of UA at its origin prevents unwanted bleeding and facilitates the laparoscopic pelvic lymphadenectomy procedure.