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    Coexistence of uterine smooth muscle tumors of uncertain malignant potential (Stump) and subserosal leiomyoma: A rare cause of postmenopausal bleeding [Malign potansiyeli belirsiz uterus düz kas tümörü (Stump) ve subserozal leiomyoma birlikteliği: postmenopozal kanamanin nadir bir nedeni]
    (Gunes Kitap Kirtasiye, 2015) Başbuğ, Alper; Başbuğ, Derya; Çağlar, Mete; Yavuzcan, Ali; Baştan, Merve; Yılmaz, Mehmet; Başar, Feyza
    Information about the clinical behaviour and risk factors of Uterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMPs) is extremely limited. Most of the patients with STUMP are at reproductive age. Postmenopausal bleeding (PMB) can occur about 10% of patients after menopause. An uterine leiomyosarcoma may be the cause of PMB in some cases but STUMPs are not a common cause of PMB. We reported here a 51-year-old woman presenting with PMB having STUMP and multiple bening subserosal leiomyomas. © 2017 Gunes Kitap Kirtasiye. All rights reserved.
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    Is unexplained elevated maternal serum alpha-fetoprotein still important predictor for adverse pregnancy outcome?
    (Via Medica, 2017) Başbuğ, Derya; Başbuğ, Alper; Gülerman, Cavidan
    Objectives: The purpose of this study was to determined the predictive value of maternal serum alpha-fetoprotein (MSAFP) as a marker for adverse pregnancy outcomes. Material and methods: This study was carried out at Dr. Zekai Tahir Burak Women's Health Education and Research Hospital between 2009 and 2010. This study included a total of 1,177 pregnant women, including 170 in the study group and 1,007 in the control group. Pregnancy outcomes and characteristics were analyzed with regard to the MSAFP value. Results: Gestational week, birth weight and APGAR scores were significantly lower in the elevated MSAFP group (p < 0.001). Adverse pregnancy outcomes, such as preterm delivery, preterm premature rupture of membranes (PPROM), oligohydramnios and intrauterine growth restriction (IUGR) rates were increased in the elevated MSAFP group. Conclusions: Although ultrasound outweighs as a screening method for neural tube defects and non-invasive prenatal testing outweighs for aneuploidy screening MSAFP level in the second trimester is still an important predictor for poor maternal/fetal outcomes.
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    MATERNAL AND NEONATAL OUTCOMES RELATED TO IRON DEFICIENCY ANEMIA AND SERUM FERRITIN STATUS: A MULTICENTER PROSPECTIVE STUDY FROM EASTERN MARMARA, TURKEY
    (2019) Pulatoglu, Cigdem; Başbuğ, Derya; Akar, Bertan; Şimşek, Hayal; Çakır, Pınar; Başbuğ, Alper; Çalışkan, Eray
    Aim: The aim was to evaluate the incidence of iron deficiencyanemia in pregnancy in the East Marmara region of Turkey in orderto determine its prevalence along with the effects and associationsof iron supplementation on maternal and neonatal outcomes.Materials and Methods: This study was conducted in sixcenters and included a total of 1102 pregnant women.Blood samples were collected for hematological status andserum ferritin levels during pregnancy, and the adversematernal and perinatal outcomes were determined. Irondeficiency anemia was diagnosed according to the WorldHealth Organization criteria as hemoglobin level of < 11g/dl and ferritin level of <15 ?g/dL.Results: The rate of anemia was 19.8%, with 44% of themreceiving iron supplementation. The maternal age was lower in theanemic group (26.5 vs. 27.7, p = 0.01). Selective iron use wasmore frequent in the anemic group, while routine iron use wasmore frequent in the non-anemic group (47.1% vs. 29.3%; p =0.01).Conclusion: Iron deficiency anemia is a frequent problem inpregnancy. However, many anemic pregnant women do notreceive iron therapy. Iron supplementation may have positiveeffects on maternal and perinatal outcomes. In order to combat irondeficiency anemia in pregnancy, wide spread use of ironsupplements should be established.
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    Maternal and neonatal outcomes related to iron deficiency anemia and serum ferritin status: A multicenter prospective study from Eastern Marmara, Turkey
    (Tekirdağ Namık Kemal Üniversitesi, 2019) Pulatoğlu, Çiğdem; Başbuğ, Derya; Akar, Bertan; Şimşek, Hayal; Çakır, Pınar; Başbuğ, Alper; Çalışkan, Eray
    Background: Iron deficiency is the most common nutritional deficit in the world. More than 50% of anemia in pregnancy results from iron deficiency and it is suggested that it may be associated with negative pregnancy outcomes. Aim: The aim of this study was to evaluate the incidence of irony deficiency anemia in pregnancy in the East Marmara region of Turkey in order to determine its prevalence in the country along with the effects and associations of iron supplementation or iron status on maternal and neonatal outcomes. Study Design: The study was designed as a prospective, longitudinal qualitative study. Method: This study was conducted in six centers in three provinces of the East Marmara region(Turkey) and included a total of 1102 pregnant women. Blood samples were collected for hematological status and serum ferritin levels during pregnancy, and the adverse maternal and perinatal outcomes were determined. Results: The rate of anemia among the women included in the study was 19.8%, with 44% of them receiving iron supplementation. The maternal age was lower in the anemic group(26.5 vs. 27.7, p = 0.01). Selective iron use was more frequent in the anemic group, while routine iron use was more frequent in the non-anemic group(47.1% vs. 29.3%; p = 0.01). Conclusions: Iron deficiency anemia is a frequent problem in pregnancy. However, many anemic pregnant women do not receive iron therapy. Iron supplementation may have positive effects on some maternal and perinatal outcomes. In order to combat iron deficiency anemia in pregnancy, widespread use of iron supplements should be established.
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    Perivascular epithelioid cell tumor of uterus with atypical immunohistochemical features
    (Gunes Kitap Kirtasiye, 2016) Başbuğ, Alper; Başbuğ, Derya; Çağlar, Mete; Yavuzcan, Ali; Baştan, Merve; Özdemir, İsmail; Başar, Feyza
    Perivascular epithelioid cell tumors (PEComa) are a rare type of mesenchymal tumor arising from perivascular epithelial cells. The prognostic classification of PEComas, the nature of their biological behaviour and the criteria determining their malignancy potential remain uncertain. PEComas usually show immunoreactivity for melanocytic (HMB-45 and/or melan-A) and smooth muscle (actin and/or desmin) markers. Surgery is the most recommended primary treatment. We reported an uterin PEComa with atypical immunohistochemical features. © 2016, Gunes Kitap Kirtasiye. All rights reserved.
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    Uterine Prolapse during First Trimester Managed with Vaginal Pessary
    (2018) Doğan, Ozan; Başbuğ, Alper; Kaya, Aşkı Ellibeş; Başbuğ, Derya; Pulatoğlu, Çiğdem
    Uterine prolapse during pregnancy is a rare condition with an estimated incidence of1:10,000–15,000 pregnancies. Premature labor and delivery are the most prevalent complicationsin pregnancies with pelvic organ prolapse. Various treatment methods from conservativeapproaches to surgery are possible. In this paper we report a 27 year-old patientwho was treated with Arabin pessary due to uterine prolapse in the first trimester.