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Öğe Low-carb diet in hospitalized late pubertal type 1 diabetic girls: A short-term CGM study(Wolters Kluwer Medknow Publications, 2021) Öz, N.; Arslanoglu, I.; Cangür, S.; Bolu, S.; Kocabay, K.Objective: We conducted the present study to observe potential short-term benefits or risks of low-carb diet (LCD). Methods: This is a prospective randomized cross-over study. Type 1 diabetic girls were hospitalized in ternary groups for 7 days and each group randomly started with LCD or regular diet. Continuous glucose monitoring (CGM) was performed between 0 and 168 h. Results: Twenty-eight subjects completed the study. Total energy, protein, and fat consumption were high (P < 0.001); carbohydrate consumption and rapidly acting insulin dose were low (P < 0.001 and P = 0.002, respectively) during LCD. Morning postprandial, noon postprandial, and evening preprandial capillary blood sugar levels were lower during LCD (P = 0.013, 0.018, and 0.048, respectively). Conclusion: LCD may have the advantage of better glycemic control despite lower insulin dose which is a favorable outcome with regard to weight control and atherosclerosis prevention. No adverse events were observed. © 2021 Indian Journal of Endocrinology and Metabolism | Published by Wolters Kluwer - MedknowÖğe Variations in monogenic diabetes and diabetes susceptibility genes in pediatric cases: single center experience(Editura Acad Romane, 2023) Arslanoglu, I.; Eroz, R.; Yavuzyilmaz, F.; Dogan, M.; Bolu, S.; Karaca, S.Context. Diabetes is a chronic disorder with a complex pathogenetic background including monogenic, polygenic, and environmental causes. Objective. The aim of the present paper is to share the information related to genetic and clinical data of large pediatric diabetes cohort. Design. The present study retrospectively analyzes genetic and clinical findings of subjects diagnosed with diabetes under the age of 18 year and are in follow-up in a pediatric diabetes referral center. Subjects and Methods. Out of 1205 children with diabetes (902 treated with insulin) 246 underwent genetic tests on the basis of clinical selection criteria since 2007. Results. One hundred and ten variants related to diabetes were found in 89 of them. Age at presentation was 9.5 +/- 4.02 years (F/M 44/45). In total 49 pathogenic and likely pathogenic, 11 hot and warm of unknown significance variants were found in fourteen MODY and fifteen nonMODY genes according to criteria developed by American College of Medical Genetics. Thirty novel mutations were found. GCK (26.6%) and ABCC8 (10%) were two most frequently affected genes. Antibody testing revealed negative results in 80% of cases. Conclusions. Genetic interpretation in selected cases is important to understand the nature of the disease better. Improvement in testing opportunity and awareness might increase the prevalence of genetically explained diabetes cases. The distribution of subtypes differs between countries and even regions of the same country.