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    Correlation of F-18-fluorodeoxyglucose uptake with histopathological prognostic factors in breast carcinoma
    (Lippincott Williams & Wilkins, 2013) Ekmekçioğlu, Özgül; Aliyev, Anar; Aksoy, Sabire Yılmaz; Arslan, Esra; Döner, Zübeyde Rana Kaya; Kocael, Pınar; Sönmezoğlu, Kerim
    ObjectiveThis study investigated the prognostic value of [F-18]-fluorodeoxyglucose (F-18-FDG) uptake in breast carcinomas by comparing F-18-FDG PET/computed tomography (CT) images with histopathological and immunohistochemical prognostic factors.MethodsThis study included 136 women and four men with positive biopsy breast carcinomas who underwent F-18-FDG PET/CT imaging for initial staging. Maximum standardized uptake values (SUVmax) and tumour-to-background SUVmax ratios were calculated and compared with histopathological and immunohistochemical tumour characteristics, patient properties and axillary lymph node involvement. Calculations of SUVmax for men were performed separately.ResultsFor the tumours in women, the mean SUVmax was 10.066.91 and the median SUVmax was 9.05 (0.7-35.0). Primary tumour F-18-FDG uptake and tumour-to-background SUVmax ratios were correlated with tumour size (P<0.001), histological type (P<0.001), histological grade (P=0.004), pleomorphism (P=0.010), mitosis count (P<0.001), lymphatic invasion (P=0.009), necrosis (P=0.005), oestrogen negativity (P=0.004), high Ki-67 level (P<0.001), axillary lymph node involvement (P<0.001) and triple negativity (P=0.002). High Ki-67 level (odds ratio=16; 95% confidence interval=1.6-160; P=0.016) and tumour size (odds ratio=4; 95% confidence interval=1.5-11; P=0.007) were determining factors for high F-18-FDG uptake values. Other clinicopathological and immunohistopathological parameters including progesterone receptor (P=0.211), CerbB2 overexpression (P=0.170), perineural invasion (P=0.053), intratumoural calcification (P=0.438), desmoplasia (P=0.112), tubular formation (P=0.768) and age (P=0.675) were not significantly correlated with F-18-FDG uptake. No significant relationship was observed between the tumour/contralateral breast SUVmax ratio and mitotic count, oestrogen receptor status or triple negativity.Conclusion(18)F-FDG uptake may serve as a prognostic indicator for biological behaviour in breast tumours. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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    The value of FDG-PET/CT by using 3-dimensional stereotactic surface projection software analysis in the differential diagnosis of dementia
    (Tubitak Scientific & Technical Research Council Turkey, 2015) Arslan, Esra; Ekmekçioğlu, Özgül; Görtan, Fatma Arzu; Akcan, Zeynep Funda Engin; Erkan, Melih Engin; Emul, Murat; Sönmezoğlu, Kerim
    Background/aim: To retrospectively reevaluate brain fluor-18-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging studies with 3-dimensional stereotactic surface projection (NEUROSTAT) software in order to detect changes in regional brain metabolism and to find out its contribution to the final diagnosis. Materials and methods: A total of 48 cases were included in this study. According to clinical evaluation and neuropsychometric test results, there were 17 (35%) patients with probable Alzheimer disease (AD), 17 (35%) patients with probable frontotemporal dementia (FTD), and 14 (30%) patients with undefined advanced dementia. Brain FDG-PET imaging studies were interpreted visually and also using 3-dimensional stereotactic surface projection. Results: Clinic and PET findings were consistent in 20 patients and inconsistent in 14 patients. When consensus diagnosis was taken as the reference, the sensitivity, specificity, accuracy, and positive and negative predictive values of FDG-PET imaging were 93%, 85%, 90%, 90%, and 89% respectively, for AD diagnosis. The same values were 85%, 93%, 90%, 89%, and 90%, respectively, for FTD definition. Conclusion: Using automatized programs that enable quantitative evaluation of regional brain glucose metabolism, in addition to visual evaluation, may increase diagnostic efficiency, as well as minimize interobserver and/or intercenter variability.