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    Factors Related to Multifocality in Papillary Thyroid Cancer: Analysis of 186 Cases
    (Düzce Üniversitesi, 2014) Arslan, Enis; Üreyen, Orhan; Emiroğlu, Mustafa; Ünalp, Haluk Recai; Tarcan, Ercüment; Güngör, Hilmi
    Objective: Papillary thyroid cancer (PTC) is the most common type of thyroid cancer, and itaccounts for 70-80% of all malignancies of the thyroid gland. The aim of the present study wasto investigate the factors associated with multifocality in PTC.Materials and Methods: The medical records of the patients (patient charts, computerizedpatient registry), who underwent thyroidectomy in our clinics between May 2005 and July 2009and who were found to have PTC, were retrospectively reviewed for the factors affectingmultifocality.Results: A total of 186 cases (26 females [14%] and 160 males [86%]) were included in thestudy. The histopathological examination revealed a single nodule in 67 cases (36%) andmultiple nodules in 119 cases (64%). PTC was unifocal in 137 cases (73.6%) and multifocal in49 cases (26.4%). The tumor diameter was smaller than 1 cm in 103 patients (55.4%) and at orabove 1 cm in 83 patients (44.6%). The tumor diameter range was 0,5-4 cm (M:1,78, SD:1,1).Of 119 patients who were found to have multiple nodules, 49 (41.1%) were found to havemultifocality, and the remaining 67 patients with single nodule did not have any multifocality.There were no significant statistical analysis between age and gender about multifocality. Conclusion: The present study showed that tumor size, gender, nodule size, selected operationtype, capsule, and vascular invasion did not affect multifocality, and the presence of multiplenodules was the most single important factor affecting multifocality. Therefore, the authorssuggest that total thyroidectomy should be performed in patients with multinodular PTCdiagnosed preoperatively due to the possibility of multifocality