Yazar "Ankarali, Seyit" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Effect of acute and chronic ellagic acid administration on penicillin induced epileptiform activity in rats
    (Natl Inst Science Communication-Niscair, 2024) Beyazcicek, Ersin; Ankarali, Seyit; Beyazcicek, Ozge; Ankarali, Handan
    One of the flavonoids found in some fruits and plants such as pomegranates, nuts, and apples is ellagic acid (EA). This compound has antidepressant, anxiolytic, antioxidant, and anti-inflammatory effects. Aim of this study was to investigate the effects of EA on experimental penicillin-induced epilepsy model electrophysiologically in rats. In this study, 70 adult male Wistar rats were divided into acute and chronic main groups. Only EA, and 10, 50 and 100 mg/kg doses of EA were the subgroups of the study. Sham and control groups were used as common groups for acute and chronic main groups. Substances were given to the acute group 30 min before the epileptiform activity started but for 21 days to the chronic group. Rats were anaesthetized with urethane. Electrodes were placed on the left somatomotor area. Electrocorticography (ECoG) recording was started and then penicillin was injected into the rats to induce epileptiform activity. 120 min more ECoG recordings were taken after penicillin was injected. In sham and only EA groups there was no epileptiform activity. Both acute and chronic groups of EA significantly increased the latency time to onset of the first spike-wave (P<0.05) and decreased the frequency and amplitude except for some time periods (P<0.05). Consequently, the administration of EA has an antiepileptic effect in penicillin-induced epilepsy in rats. Therefore it may be a potential anti-epileptogenic drug in the future.
  • Küçük Resim
    Öğe
    Statistical Properties of Sampling Distributions of Different Test Statistics for Different Measures of Change and a New Test: Simulation Study
    (Soc Statistics Computer & Applications, 2020) Ankarali, Handan; Cangur, Sengul; Ankarali, Seyit
    The aim of this study is to analyse the distribution characteristics of four different test statistics, namely the Mean/Standard Error of Mean (Mean/SEmean), Median/Interquartile Range (Median/IQR), Trimmed Mean/Standard Error of Mean (TrMean/SEmean), and Trimmed Mean/Interquartile Range (TrMean/IQR), which can be used to test two measures of change, namely percent change (PC) and modified symmetrised percent change (MSPC). To ensure the selection of suitable test statistics using the two measures of change, the observed type-I errors and powers of the test statistics have been computed. Results demonstrate that the sampling distributions of the four different test statistics by using PC values exhibit skewness. The Mean/SEmean statistic for the MSPC measure exhibits a two-peak value and platykurtic distribution, while the TrMean/SEmean statistic shows a leptokurtic distribution. The Median/IQR test yields robust and powerful results, especially for large sample sizes. This new statistical measure is referred to as the HS test.
  • Küçük Resim
    Öğe
    The Effect of Probiotic Consumption Status and Quality of Life in Patients with Fibromyalgia
    (Düzce Üniversitesi, 2023) Celik Yalcin, Seher; Pasin, Tuğçe; Ankarali, Seyit
    Aim: Recent studies have suggested that disruptions in the gut microbiota could potentially contribute to the pathogenesis of chronic pain and fibromyalgia syndrome (FMS) by affecting the gut microbiota-brain axis. The increasing prevalence of fibromyalgia syndrome has prompted investigations into the impact of probiotic food consumption, which regulates the microbiota, on quality of life.Material and Methods: The study included 99 patients diagnosed with fibromyalgia syndrome who presented to our Physical Medicine and Rehabilitation outpatient clinic. A questionnaire was administered to assess the patients' knowledge and consumption of probiotic foods, and the Short Form-12 Health Survey(SF-12) was used to gather data and assess health-related quality of life.Results: Of the 99 patients who completed the questionnaire, 89 were female and 10 were male. In response to the question, "Do you know what probiotics are?"7.4% of primary school graduates,64.7% of high school graduates, and 78.6% of university graduates answered affirmatively. When asked, "Have you experienced any benefits from probiotic foods?" 21.2% responded positively, and among those who experienced benefits, the most common accompanying issue (37.04%) was Irritable Bowel Syndrome(IBS). Fibromyalgia syndrome patients who consumed yogurt as a probiotic had higher physical function subdomain scores on the SF-12 Health Survey.Conclusion: The high level of education in FMS patients increased the awareness of probiotics. Probiotic consumption may have a improving effect on irritable bowel syndrome and constipation associated with FMS.Training on probiotics and increasing the frequency of use of probiotics, the quality of life of FMS patients can be increased and accompanying symptoms can be reduced.