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    Effect of Prenatal Exposure to Diclofenac Sodium on the Development of Arteries in the Female Rat A Stereological and Histopathological Evaluation
    (Sci Printers & Publ Inc, 2016) Çolakoğlu, Serdar; Altunkaynak, Muhammed Eyüp; Zengin, Halit; Elibol, Ebru; Altunkaynak, Berrin Zuhal; Kesim, Yüksel; Kaplan, Süleyman
    OBJECTIVE: To investigate the effect of diclofenac sodium (DS) exposure on the prenatal development of female rat arteries. STUDY DESIGN: Pregnant rats were separated into control, saline-injected, and drug-treated (DS) groups. Starting from the 5th day following mating until the 15th day of pregnancy, saline and DS (1 mg/kg daily) were injected intraperitoneally into the pregnant rats in the saline and DS groups, respectively. No injection was given to the rats in the control group. Of the offspring born to the pregnant rats, females were chosen. At the end of the 4th and 20th weeks, vessel samples were removed and evaluated using stereological techniques. RESULTS: Our results indicated no significant difference between the volume fractions of the tunica media and lumen in the femoral and brachial arteries of the 4-week-old female rats. Moreover, there were no significant differences between the 4- and 20-week-old female rats in terms of the volume fractions of the tunica media and lumen in their aortas and femoral and brachial arteries. However, a significant difference was observed in the condition of the 4-week-old female rats' aortas. CONCLUSION: Prenatal exposure of female rats to DS may inhibit the development of the arterial system.
  • Küçük Resim Yok
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    Effect of prenatal exposure to diclofenac sodium on the development of arteries in the female rat: A stereological and histopathological evaluation
    (Science Printers and Publishers Inc., 2016) Çolakoğlu, Serdar; Altunkaynak, Muhammed Eyüp; Zengin, Halit; Elibol, Ebru; Altunkaynak, Berrin Zuhal; Kesim, Yüksel; Kaplan, Süleyman
    Objective: To investigate the effect of diclofenac sodium (DS) exposure on the prenatal development of female rat arteries. Study Design: Pregnant rats were separated into control, saline-injected, and drug-treated (DS) groups. Starting from the 5th day following mating until the 15th day of pregnancy, saline and DS (1 mg/kg daily) were injected intraperitoneally into the pregnant rats in the saline and DS groups, respectively. No injection was given to the rats in the control group. Of the offspring born to the pregnant rats, females were chosen. At the end of the 4th and 20th weeks, vessel samples were removed and evaluated using stereological techniques. Results: Our results indicated no significant difference between the volume fractions of the tunica media and lumen in the femoral and brachial arteries of the 4-week-old female rats. Moreover, there were no significant differences between the 4- and 20-week-old female rats in terms of the volume fractions of the tunica media and lumen in their aortas and femoral and brachial arteries. However, a significant difference was observed in the condition of the 4-week-old female rats' aortas. Conclusion: Prenatal exposure of female rats to DS may inhibit the development of the arterial system. © Science Printers and Publishers, Inc.
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    Effects of prenatal exposure to diclofenac sodium and saline on the optic nerve of 4- and 20-week-old male rats: a stereological and histological study
    (Taylor & Francis Ltd, 2014) Çolakoğlu, Serdar; Aktaş, Abit; Raimondo, Stefania; Türkmen, Aysın Pınar; Altunkaynak, Berrin Zuhal; Odacı, Ersan; Kaplan, Süleyman
    We investigated the effects of diclofenac sodium (DS) on development of the optic nerve in utero. Pregnant female rats were separated into three groups: control, saline treated and DS treated. Offspring of these animals were divided into 4-week-old and 20-week-old groups. At the end of the 4th and 20th weeks of postnatal life, the animals were sacrificed, and right optic nerves were excised and sectioned for ultrastructural and stereological analyses. We demonstrated that both DS and saline produced structural and morphometric changes in the total axon number and density of axons, but decreased the myelin sheath thickness in male optic nerves. All ultrastructural and morphometric features were well developed in 20-week-old rats. We showed that development of the optic nerve continues during the early postnatal period and that some compensation for exposure to deleterious agents in utero may occur during early postnatal life.