Yazar "Altun, Gulsah" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim Yok
    Öğe
    A case of malignant melonoma presenting with upper gastrointestinal bleeding.
    (Ramazan AKDEMİR, 2019) Altun, Gulsah; Önmez, Attila; Öneç, Kürşad; Kurtoğlu, Burak; Torun, Serkan; Eşbah, Onur
    Malignant melanoma can metastasize to the gastrointestinal tract as it can metastasize to many parts of the body. Small bowel is the most common involvement in gastrointestinal tract, while gastric involvement is rare. A 82-year-old male patient who presented to the emergency department with complaints of hematemesis and melena had a large number of black polypoid masses in the gastric corpus and antrum in his gastroscopic  examination. And the result of the biopsy taken from that part, was malignant melanoma. In this way, it is very rare that a patient who is not known to have malignant melanoma, presents with upper gastrointestinal bleeding.
  • Küçük Resim Yok
    Öğe
    Etanercept-Induced Thrombocytopenia In A Patient With Ankylosing Spondylitis
    (DAHUDER, 2022) Önmez, Attlla; Altun, Gulsah; Akbaş, Türkay; Öneç, Birgül
    Tumor necrosis factor-alpha (TNF-?), which is produced by macrophages and activated T lymphocyte cells, plays a main role in inducing further stimulation of other inflammatory cells. Anti-TNF-? drugs are used for induction and preservation of remission in patients with Ankylosing spondylitis. Etanercept, which is one of the most used Anti-TNF-? drugs, has side effects such as cytopenia but isolated thrombocytopenia is an uncommon adverse event. We report the case of a 40-year-old man diagnosed with Ankylosing spondylitis who developed Etanercept-induced isolated thrombocytopenia.
  • Küçük Resim
    Öğe
    The Relationship of Hepcidin, Soluble Transferrin Receptor, Growth Differentiation Factor-15 And Anemia in Multipl Myeloma
    (Duzce Univ, Fac Medicine, 2023) Onec, Birgul; Kos, Durdu Mehmet; Altun, Gulsah; Sungur, Mehmet Ali
    Objective: Multiple myeloma (MM) is a malignant hematological disease and anemia is observed in the majority of patients. Hepcidin, Growth differentiation factor-15 (GDF-15), soluble transferrin receptor (sTfR) have been investigated in many forms of anemia, especially in chronic diseases and cancers. However, there are few studies investigating their role in MM. We aimed to determine the relationship between hepcidin, sTfR and GDF-15 levels in MM patients and their clinical features such as anemia parameters, disease stage and overall survival.Methods: Hepcidin, sTfR and GDF-15 levels, as well as clinical and anemia-related parameters, were analyzed in newly diagnosed MM patients and healthy volunteers.Results: Although MM patients had significantly lower Hb and Hct levels compared to the control group, none of the GDF-15, hepcidin and sTfR levels showed a significant difference between the groups. Among MM patients, we found that the anemic subgroup had significantly lower hepcidin levels than the non-anemic subgroup. GDF-15, hepcidin and sTfR levels showed weak or moderate, but statistically significant positive correlation with each other, while GDF15 was positively correlated with creatinine and sTfR levels were correlated with many parameters such as LDH, CRP, ferritin, albumin, creatinine, Hb and ISS, all of which weak. None of the levels of GDF-15, hepcidin and sTfR had a significant effect on survival.Conclusions: We suggested that these mediators may play a role in anemia of MM but there is not a clear relashionship as in chronic disease anemia, there may be different mechanisms according to the characteristics of the patient groups.
  • Küçük Resim
    Öğe
    Treatment of critically ill patients with acute hypercarbic respiratory failure by average volume-assured pressure support mode
    (Wiley, 2021) Akbas, Turkay; Altun, Gulsah
    Objectives Average volume-assured pressure support (AVAPS), a dual mode, delivers a set tidal volume (TV) per kg by adjusting the pressure between upper and lower inspiratory positive airway pressures (IPAP). Thus, ventilation is presumed to be happened effectively by sending a guaranteed TV. This study was aimed to evaluate the effectiveness of AVAPS mode in critically ill patients with acute hypercarbic respiratory failure (HRF) and compare the results with bilevel positive airway pressure-spontaneous/timed (BPAP-S/T) mode. Methods Sixty patients were assigned to BPAP-S/T (n = 29) and AVAPS modes (n = 31). Maximum IPAP was started at 20 cmH(2)O and minimum IPAP was set at 5 cmH(2)O higher than expiratory positive airway pressure (EPAP) in AVAPS mode. IPAP was started at 15 cmH(2)O in BPAP-S/T mode. IPAP levels were titrated up to 30 cmH(2)O during noninvasive mechanic ventilation (NIMV) with a targeted TV of 6-8 mL/kg. Patients were followed for 5 days. Results No differences were found in pH, paCO(2), HCO3, TV and EPAP between the two groups when compared separately by days. Maximum IPAP levels were significantly high in AVAPS mode in all times (P < 0.001). The length of stay (LOS) in intensive care unit (ICU) (P = 0.994) and hospital (P = 0.509), hours of NIMV use per day (P = 0.101) and NIMV success rate (P = 0.931) were identical between the two groups. ICU (P = 0.931), hospital (P = 0.800), 6-month (P = 0.919) and 1-year (P = 0.645) mortality rates were also not different between the both groups. Conclusions AVAPS mode had similar efficiency with BPAP-S/T mode regarding the NIMV treatment success in critically ill patients with acute HRF.