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    Acute Effects of Red Bull Energy Drinks on Atrial Electromechanical Function in Healthy Young Adults
    (Excerpta Medica Inc-Elsevier Science Inc, 2020) Ozde, Cem; Kaya, Adnan; Akbudak, Ismail Hakki; Akture, Gulsah; Kayapinar, Osman
    Energy drinks (EDs) are widely consumed by adolescents and young adults. Almost all kinds of arrhythmias have been reported following EDs consumption, most of which is atrial fibrillation (AF). Atrial conduction time prolongation and heterogeneous sinusal impulses propagation to the atriums are the key electrophysiological mechanisms leading AF. We aimed to evaluate the acute effects of Red Bull ED ingestion on atrial electromechanical conduction times in healthy young adults. After a 12-hour fasting, 54 healthy young adults consumed 330 mL of Red Bull ED. Atrial electromechanical coupling (PA), intra-atrial electromechanical delay (intra-AEMD), and interatrial electromechanical delay (inter-AEMD) were measured at baseline and 2-hour after Red Bull ED ingestion by echocardiographic tissue-Doppler imaging (TDI) method. PA-lateral (49.7 +/- 11.2 vs 54.1 +/- 11.0 msn, p = 0.001) and PA-septal (40.8 +/- 9.1 vs 43.7 +/- 10.5 msn, p = 0.032) times were statistically significantly prolonged after Red Bull ED ingestion. There was also a statistically significant increase in the duration of inter-AEMD (14.4 +/- 10.6 vs 18.1 +/- 8.5 msn, p = 0.010) after ED ingestion. It was showed that even a single can of ED can acutely increase atrial electromechanical conduction times in young adults. These findings may be the cause of ED-associated AF. (C) 2019 Elsevier Inc. All rights reserved.
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    Evaluation of Serum Soluble Lectin-like Oxidised Low-Density Lipoprotein Receptor-1 (sLOX-1) Level in Children with Non-Complicated Type-1 Diabetes Mellitus (T1DM) and Its Relationship with Carotid Intima Media Thickness (cIMT)
    (Mdpi, 2025) Ozde, Sukriye; Yavuzyilmaz, Fatma; Ozel, Mehmet Ali; Kayapinar, Osman; Ozde, Cem; Akture, Gulsah; Arslanoglu, Ilknur
    Background: The objective of this study was to evaluate serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in children with type-1 diabetes mellitus (T1DM) without any atherosclerotic complications and to investigate whether there was an association with early atherosclerotic processes in these children. Methods: The study's design entailed a prospective cross-sectional observational study methodology. The patient group consisted of 80 consecutive children aged 8-18 years who had been diagnosed with T1DM for at least ten years and had not developed any chronic clinical complications related to T1DM. The control group consisted of 72 completely healthy children with similar demographic characteristics. Serum levels of sLOX-1 were measured, and carotid intima-media thickness (cIMT) was evaluated using ultrasonography in all subjects. Results: A statistical analysis of the results was conducted. The serum sLOX-1 level was found to be significantly higher in the patient group than in the control group (0.49 +/- 0.11 vs. 0.82 +/- 0.35; p < 0.001). The statistical significance observed was maintained in the multivariable logistic regression analysis (p < 0.001). A significant correlation was identified between cIMT and serum sLOX-1 levels (r = 0.669, p < 0.001). The receiver operating characteristic curve for sLOX-1 indicated that a cutoff value greater than 0.65 ng/mL was associated with T1DM. Conclusions: Serum sLOX-1 levels were markedly elevated in children with T1DM who had not yet manifested chronic complications. These findings suggest that elevated serum sLOX-1 levels may be associated with the progression of atherosclerosis in children with T1DM.
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    Evaluation of the systemic-immune inflammation index (SII) and systemic immune-inflammation response index (SIRI) in children with type 1 diabetes mellitus and its relationship with cumulative glycemic exposure
    (Walter De Gruyter Gmbh, 2024) Ozde, Sukriye; Akture, Gulsah; Ozel, Mehmet Ali; Yavuzyilmaz, Fatma; Arslanoglu, Ilknur; Ozde, Cem; Kayapinar, Osman
    Objectives: In this study, the systemic proinflammatory status was assessed using the systemic immune-inflammation index (SII) and SIRI systemic immune-inflammatory response index (SIRI) in children and adolescents with type 1 diabetes mellitus (T1DM). Methods: The study involved 159 patients aged between 6 and 16 years. The SII and SIRI values were calculated based on the complete blood count. Basic blood biochemistry evaluated, and carotid intima-media thickness (cIMT) was measured and recorded. The cumulative glycemic exposure was calculated by multiplying the value above the normal reference range of the HbA1c value. The sum of all these values obtained from the time of diagnosis to obtain the cumulative glycemic exposure. All findings were compared statistically. All statistically significant parameters were evaluated in the multivariate logistic regression analysis. Results:The analysis revealed that only cIMT (Exp(B)/OR: 0.769, 95 % CI: 0.694-0.853, p<0.001), high-density lipoprotein (Exp(B)/OR: 3.924, 95 % CI: 2.335-6.596, p<0.001), monocyte count (Exp(B)/OR: 1.650, 95 % CI: 1.257-2.178, p<0.001), hematocrit (Exp(B)/OR: 0.675, 95 % CI: 0.523-0.870, p<0.001), and SIRI (Exp(B)/OR: 1.005, 95 % CI: 1.002-1.008, p<0.001) were significantly associated with T1DM. A statistically significant positive association was found between cumulative glycemic exposure and SIRI only (r=0.213, p=0.032). To our knowledge, this is the first study to evaluate SII and SIRI in children with type 1 diabetes. Conclusions: These findings indicate that SIRI could serve as a potential biomarker for detecting early-onset proatherosclerotic processes in diabetic children. However, further clinical studies are required to confirm this.
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    Radial Artery Thrombosis and Associated Risk Factors in Patients Undergoing Radial Coronary Angiography
    (Touch Medical Media Ltd, 2024) Koc, A. Y. Esra; Naldemir, Ibrahim Feyyaz; Ozde, Cem; Akture, Gulsah; Aytekin, Seda; Kayapinar, Osman; Karaca, Gurkan
    Background: Radial access is considered the preferred method for coronary angiography (CAG) and percutaneous coronary intervention. Radial artery thrombosis (RAT) stands out as the primary complication associated with trans- radial access. Our objective was to explore the occurrence of RAT and its associated risk factors. Method: A study encompassing 150 patients who underwent coronary interventions via radial access was conducted. Colour Doppler ultrasonography was used to assess proximal and distal radial flow rates 4-6 hours post- procedure. Patients diagnosed with RAT constituted the study group, while those without RAT were designated as controls. Results: Among the 150 patients, 20 (13.3%) developed RAT, with partial occlusions observed in 2.7% and total occlusions in 10.7%. Univariate analysis identified potential correlations between RAT and variables such as female gender, hypertension (HT), history of coronary artery disease, use of anti- thrombocyte medications, duration of compression, indication for CAG, haematocrit levels, neutrophil count, creatinine levels and estimated glomerular filtration rate. However, only HT showed a statistically significant association. Multivariate analysis confirmed HT, anti- thrombocyte drug use, duration of compression, haematocrit levels and creatinine levels as independent predictors of RAT. Conclusion: HT, anti- thrombocyte drug use, duration of compression, haematocrit levels and creatinine levels are identified as independent predictors of RAT. Standard pulse examination may not adequately detect RAT.