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  • Küçük Resim
    Öğe
    Protective Effect of Urtica dioica on Liver Injury Induced by Hepatic Ischemia Reperfusion Injury in Rats
    (Düzce Üniversitesi, 2010) Yıldız, Fahrettin; Çoban, Sacit; Taşkın, Abdullah; Bitiren, Muharrem; Aksoy, Nurten; Terzi, Alpaslan
    Background: This study was designed to investigate the effects of Urtica dioica on liverischemia reperfusion injury in rats. Methods: Thirty male Wistar-albino rats were used in this experimental study. Animals weredivided into three groups as sham operated (group 1), control (group 2), and Urtica dioicatreatment group (group 3). Urtica dioica 2ml/kg were administered intraperitoneally beforeischemia and immediately after the reperfusion. The levels of total antioxidant capacity, totalfree sulfidril group, Total oxidant status, Oxidative stress index, and myeloperoxidase in livertissues were measured. The serum levels of ALT, AST and LDH were also measuredResults: Total antioxidant capacity and total free sulfidril group in liver tissue were significantlyhigher in group 3 than in group 2. Oxidative stress index and myeloperoxidase in liver tissuewere significantly lower in group 3 than the group 2. The levels of liver enzymes in treatmentgroup were significantly lower than those in the control group. Histological tissue damage wasmilder in the treatment group than that in the control group.Conclusion: It is concluded that Urtica dioica increase the antioxidant capacity and decreaseoxidative stress and liver enzymes in the hepatic ischemi reperfusion injury of rats
  • Küçük Resim
    Öğe
    The Association Between Microalbuminuria and Carbonmonoxide Diffusion Capacity in Patients with Type-II Diabetes Mellitus
    (Düzce Üniversitesi, 2011) Çelik, Yakup; Eren, Mehmet Ali; Dağ, Omer Faruk; Gencer, Mehmet; Çelik, Hakim; Aksoy, Nurten; Büyükhatipoglu, Hakan
    Aim: Microalbuminuria is an important indicator of microvascular changes. Identifying patientsat this stage is critical, since nephropathy might be at least partly reversible with aggressiveblood glucose control. Based on these facts, we aimed to evaluate whether any microvascularchanges occur in the lungs before microalbuminuria becomes apparent.Material and Methods: We research carbonmonoxide diffusion capacity (DLCO) in bothnormoalbuminuric and microalbuminuric type 2 diabetes mellitus patients. Age and gendermatched 40 microalbuminuric and 40 normoalbuminuric type 2 diabetes mellitus patients, and40 healthy controls were recruited to this study.Results: We evaluated DLCO results among these groups. We found no difference betweenthree groups in terms of DLCO (p=0.947).Conclusion: The results of the study indicate that as microvascular complications(microalbuminuria) develop in the kidneys, possibly no microvascular changes occur in thelungs, if any, the changes do not cause any functional changes in type 2 diabetes mellitus patientsat early stages