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    Analysis of 3702 patients with acne vulgaris and concomitant comorbidities in Turkey: a multi-centered, prospective, controlled study
    (Wiley, 2021) Unal, Emine; Karadag, Ayse Serap; Akturk, Aysun Sikar; Namdar, Nazli Dizen; Kelekci, Kiymet Handan; Aksoy, Berna; Balta, Ilknur
    Background Acne vulgaris is a chronic inflammatory skin disease that affects the pilosebaceous unit. Although it is considered to be a skin-limited disease, different clinical studies have recently been published in which the disease is accompanied by systemic symptoms. In this study, systemic comorbidities accompanying acne vulgaris and the relationship between existing comorbidities and disease severity are investigated. Methods This prospective multicenter study was conducted by the Turkish Society of Dermatology Acne Study Group. Twelve dermatology clinics and 14 clinicians throughout Turkey participated in the study. A structured physician-administered questionnaire was used to collect patient demographics, clinical findings, and lifestyle data. Physicians recorded each participant's medical history, including current and past comorbidities, duration of any comorbidity, smoking, and drinking. Body mass index (BMI) was calculated. Results There were 3022 patients in the adolescent acne group and 897 in the control group. The incidence of nonmigraine headache in adolescents with acne was significantly higher than in the nonacne group (P = 0.019). There were 680 patients in the postadolescent acne group and 545 in the control group. In the postadolescent group, incidence of metabolic disease was lower than the control group (P = 0.003). In the postadolescent group, premenstrual syndrome (P < 0.001) and PCOS (P = 0.007) were more common than the control group. Conclusions In this study, we observed that acne vulgaris does not cause systemic comorbidities. There is also a need for new studies involving a large number of patients to illuminate systemic diseases accompanying acne vulgaris.
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    Correlation study between clinical classification and disability index in a holistic evaluation of acne severity and impact in Turkey
    (Edizioni Minerva Medica, 2021) Özlü, Emin; Karadağ, Ayşe Serap; Aksoy, Berna; Bilgili, Serap Güneş; Gönül, Müzeyyen; Yavuz, İbrahim H.; Şenel, Engin
    BACKGROUND: This study provides a comparison between disease severity observed by inspectors and the disease burden assessed by patients is scanty in acne study. METHODS: In a multicenter prospective hospital-based study, modified Comprehensive Acne Severity Scale (mCASS) and Cardiff Acne Disability Index (CADI) were employed to grade disease severity and to determine the quality of life, respectively. The average of the mCASS and CADI scores, with range at 0-25, was termed as Acne Severity and Impact Grading System (ASIG). RESULTS: In 1331 evaluated patients (mean: 21,51 +/- 4,93 years), including 306 men and 1025 women, an overall significant, positive correlation was found between ASIG and mCASS (r=0.862), or CADI (r=0.686), respectively (P=0.001 each). Adult women with back acne and adolescent with decollete expressed greater concern (higher CADI) than the clinical severity (lower mCASS). The overall prevalence of acne in decollete area, including neck, was 32.3%. CONCLUSIONS: Discrepancies in the acne severity between self-perception and objective evaluation exist in certain subgroups of patients. Decollete acne deserves special attention in clinical assessment. (Cite this article as: Ozlu E, Karadag AS, Aksoy B, Gunes Bilgili S, Gonul M, Yavuz IH, et al. Correlation study between clinical classification and disability index in a holistic evaluation of acne severity and impact in Turkey. Ital J Dermatol Venereol 2021;156:669-74. DOI: 10.23736/S27848671.20.06738-3)