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    Evaluation of the Relationship between Silent Cerebral Lesions and Triglyceride/HDL-Cholesterol in Patients with First Stroke Attack
    (2020) Atasoy, Hüseyın Tugrul; Çelebi, Ulufer; Demirel, Esra Acıman; Acikgoz, Mustafa; Kalaycı, Gülcan; Çınar, Bilge Piri
    im: Triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is defined as theserum atherogenicity index. High TG/HDL-C ratio is related with vascular diseases, insulinresistance and metabolic syndrome. The TG/HDL-C ratio in cerebrovascular diseases,especially in silent cerebral lesions hasn’t been well studied. The aim of this study was toevaluate the frequency of silent cerebral ischemia (SCI) and leukoaraiosis (LA), and itsrelationship with TG/HDL-C ratio in patients admitted with the first ischemic stroke attack.Material and Methods: We retrospectively evaluated 200 patients who admitted to BulentEcevit University Faculty of Medicine, Department of Neurology with the diagnosis of acutefirst ischemic stroke. Silent cerebral lesions were defined as LA and SCI with magneticresonance imaging. TG/HDL-C ratio was calculated by dividing TG levels by HDL-C levels.Results: Silent cerebral lesions were detected 124 (83.2%) of 149 patients. LA severity wasevaluated according to Fazekas score, 22 (14.8%) of patients were grade 0, 49 (32.9%) of themwere grade 1, and 78 (52.3%) of them were advanced periventricular white matterhyperintensity (adv-PWMH) group. TG/HDL-C ratio in SCI group was higher than the groupwithout SCI, but it wasn’t statistically significant (p=0.091). A significant increase wasobserved in the TG/HDL-C ratio, as LA severity increased. TG/HDL-C ratio was significantlyhigher in adv-PWMH group (p=0.050).Conclusion: High serum atherogenicity index is associated with atherosclerosis and vascularendothelial dysfunction. With this simple, inexpensive and effective test method, high-riskgroup of LA and SCI could be identified.