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    Vitamin B12 Deficiency and Thrombosis
    (Düzce Üniversitesi, 2009) Yavasoglu, İrfan; Kadıkoylu, Gurhan; Acar, Bilal; Bolaman, Zahit
    Purpose: Thromboembolic diseases are multi-factorial. Hyperhomocysteinemia (HH) is one of these factors. Vitamin B12 deficiency is acquired reasons for HH. HH is a risk factor for arterial and venous thrombosis. The incidence of thrombosis is high due to increase of homocystein levels in HH associated with vitamin B12 deficiency. However, this situation is not clear and there are opposing views. In our study, we aimed to determine the frequency of thromboembolic events in individuals with vitamin B12 deficiency. Methods: One hundred forty-three patients (63 female, 80 male, mean age 59±13 years), who were diagnosed as having vitamin B12 deficiency (below 200 pg/ml), were included in the study retrospectively. The history of arterial and venous thrombosis for a period of last three years before the time of diagnosis and was searched. The thromboembolic events, which are detected via clinical and laboratory studies and via imaging, were determined. The control group was consisted of 129 healthy subjects (62 female, 67 male; mean age 58±8) of appropriate age, sex and excluded criteria whose B12 level was normal. Results: In control group, mean B12 level was 244±32 pg/ml. The patients’ mean B12 level was 136±58 pg/ml. Fourteen (9.8%) thromboembolic (10 coronary artery disease, two deep venous thrombosis, two cerebrovascular) events were determined in vitamin B12 deficiency group, whereas this ratio was 3.9% in the control group (four coronary artery disease, one deep venous thrombosis). This ratio was not statistically significant different (p gt; 0.05). Conclusion: Alone HH due to vitamin B12 deficiency did not increase the risk of thrombosis