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Öğe Agonist and Antagonist Effects of ATP-Dependent Potassium Channel on Penicillin Induced Epilepsy in Rats(2016) Acar, Yıldız; Özmerdivenli, Recep; Demir, Şerif; Beyazçiçek, Ersin; Ankaralı, Seyit; Beyazçiçek, Özge; Ankaralı, HandanAMAÇ: Epileptik nöbetler, beyindeki uyarıcı ve duraklatıcı sistemler arasındaki dengenin, uyarıcı sistemlerin aktivitelerinin artışı yönünde bozulması sonucunda meydana gelir. İn vitro ve in vivo çalışmalarında, birçok K kanal açıcılarının antiepileptik etkisi gösterilmiştir. Bu çalışmada, çeşitli deneysel epilepsi modellerinde etkisi araştırılan KATP kanal agonist (pinacidil) ve antogonistlerinin (glibenclamide) penisilinle oluşturulan deneysel epilepsi modeli üzerindeki akut etkisi araştırıldı.YÖNTEM: Çalışmada 200-250 gr ağırlığında 32 adet erkek WistarAlbino sıçan kullanıldı. Deney 10 hayvanları, kontrol, DMSO (dimetilsülfosit), pinasidil ve glibenklamid olarak dört gruba ayrıldı. Sıçanlar 1,25 gr/kg üretan dozunun intraperitoneal olarak uygulanmasıyla anestezi altına alındı. Sıçanlar anestezi altına alındıktan sonra sol korteks açıldı ve somatomotor alana elektrotlar yerleştirildi. Epileptiform aktivite intrakortikal (i.c.) penisilin (500 IU, 2,5 ?l) uygulanmasıyla oluşturuldu. Penisilin uygulamasının 30. dakikasında tüm maddeler (salin, DMSO, pinasidil ve glibenklamid) intraperitoneal 15 (i.p.) olarak uygulandı. Kayıtlardan elde edilen elektrokortikografik (ECoG) veriler yazılım programı ile analiz edildi. Epileptiform aktivitenin diken dalga sıklığı ve diken dalga genliği istatistiksel olarak analiz edildi.BULGULAR: Penisilin ile oluşturulan deneysel epilepsi modelinde pinasidilin diken dalga sıklığını azalttığı (p0,05), fakat diken dalga genliği üzerinde anlamlı bir etkisinin olmadığı görüldü (p0,05). Benzer şekilde KATP kanal kapatıcısı olan glibenclamidenin ise hem diken dalga sıklığı hem diken dalga genliği üzerine anlamlı bir etkisinin olmadığını bulundu (p0,05).SONUÇ: Yapılan çalışmada pinasidil uygulamasının sıçanlarda penisilinle oluşturulmuş deneysel epilepsi modeli üzerinde antiepileptik etkiye sahip olduğu gösterildi. Pinasidil gelecekte potansiyel bir antiepileptik ilaç olabilir.Öğe Agonist and Antagonist Effects of ATP-dependent Potassium Channel on Penicillin-induced Epilepsy in Rats(Wiley-Blackwell, 2016) Beyazçiçek, Ersin; Acar, Yıldız; Özmerdivenli, Recep; Demir, Şerif; Ankaralı, Seyit; Beyazçiçek, Özge; Ankaralı, Handan…Öğe Antioxidant therapy impresses in oxidative stress-induced kidney cells(Comenius Univ, 2017) Alpay, Merve; Kısmalı, Görkem; Meral, Öğünç; Sel, Tevhide; Özmerdivenli, Recep; Pasin, ÖzgeINTRODUCTION: Renal cell cancer (RCC) is not a single entity, but consists of different types of tumors derived from various parts of the nephron (epithelium or renal tubules). It is known that cancer initiation and progression is related to the balance between oxidants and antioxidants directly. Interestingly, advanced stages of cancer such as metastasis, angiogenesis are associated with cell oxidative capacity. Familiar antioxidative substances such as carotenes and vitamin C inhibit oxidation of other molecules during carcinogenesis. They can define the distinction between cancer and normal cells, destroying cancer cells while stabilizing healthy cells. METHODS: apoptotic activities of kidney cells were measured with caspase Elisa kits. DNA laddering test was used to show DNA damage in H2O2 condition. RESULTS: For tumor mechanism, they act as pro-oxidants, producing hydrogen peroxide that attacks the cancer, whereas, in normal conditions they act as protective antioxidants. CONCLUSIONS: The unlike reaction of specific antioxidants should be known at different cell stages. The aim of this study was to assess the antioxidative roles of alpha lipoic acid on kidney cancers during oxidative stress induction (Tab. 1, Fig. 7, Ref 27). Text in PDF www.elis.sk.Öğe Atletizm Sporcularının Doping Türleri ve DopingleMücadele Hakkındaki Görüşlerinin Belirlenmesi(2017) Çelebi, Evrim; Gündoğdu, Cemal; Beyazçiçek, Ersin; Özmerdivenli, RecepAmaç: Bu araştırma atletizm milli takım sporcularının, sporda kullanılan doping türleriyle ilgili bilgi düzeylerinin ve dopingle mücadele konusundaki görüşlerinin belirlenmesi amacıyla yapılmıştır. Gereç ve Yöntem: Tanımlayıcı 7 türdeki araştırma, Türkiye Atletizm Federasyonu'nun faaliyet programında yer alan Süper Lig Final yarışmaları ve Gençler Avrupa Şampiyon Kulüpler Kupası yarışmalarına katılan ve araştırmaya katılmayı kabul eden 73 sporcu ile yürütülmüştür. Veri toplama aracı olarak araştırmacılar tarafından hazırlanan anket formu kullanılmıştır. Veriler sayı ve yüzde olarak ifade edilmiş, analizde ki kare testi kullanılmıştır. Bulgular: Sporcuların %79.5'i sporda en çok uyarıcıların kullanıldığını belirtmiştir. Bunu %68.5 ile anabolik androjenik steroidler, %65.8 ile anti-östrojenik ajanlar izlemiştir. Sporcuların yaklaşık üçte ikisi dopingin sporcular, antrenörler ve idareciler tarafından yeterince bilindiğini (%64.4), kendilerinin de bu konuda bilgi sahibi olduğunu (%64.4) ve dopingle ilgili yayınlar okuduğunu (%65.8) ifade etmiştir. Sporcular, dopingle mücadele konusunda başta devlet (%76.7), federasyon (%82.2) ve kulüpler (%63.0) olmak üzere ilgili kurum ve kuruluşların faaliyetlerini yeterli bulmaktadır. Sonuç: Sonuç olarak araştırmaya katılan sporcular arasında en çok fikir sahibi olunan doping türlerinin başında uyarıcıların ve anabolik-androjenik steroidlerin yer aldığı, sporcuların yaklaşık üçte ikisinin, dopingin sporcular, antrenörler ve idareciler tarafından yeterince bilindiği ve kendilerinin de bu konuda bilgi sahibi olduklarını düşündüğü, sporcuların yarıdan fazlasının, dopingle mücadele konusunda ilgili kurum ve kuruluşların faaliyetlerini yeterli buldukları belirlenmiştir.Öğe Autistic feature and 2D: 4D finger ratio relations children and adolescents with congenital adrenal hyperplasia(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2017) Kocaman, Gizem Melissa; Özmerdivenli, Recep; Yektaş, Çiğdem; Bolu, Semih; Haskılıç, Yunus Emre; Erdoğan, AytenObjective: Because congenital adrenal hiperplazi (CAH) and autism spectrum sisorders (ASD) is rarely seen, it is difficult to assess whether the increased incidence of ASD in girls with CAH. ASD behaviors and 2D: 4D finger ratio changes in patients with androgen overproduction have been reported. The aim of this study is determining the 2D: 4D finger ratios and ASD features in girls with CAH and normal control group. Methods: The study group will consist of thirty female children and adolescents between the ages of 3 and 15 who are diagnosed with classic CAH who were followed at the Pediatric Endocrinology Department of Duzce University Medical Faculty Hospital. For the control group, 30 healthy children and adolescents equalized with CAH patients in terms of age and gender will be taken. Al patients and controls examined for psychiatric disorders. by clinicians Patients and control groups filled Autism Behavior Checlist and semistructured sociodemogrphic form that evaluated the gender, age, pregnancy and birth complications, history of mothers' cigarette and alcohol use. 2D: 4D ratios were measured in both of control and CAH groups. Results: KAH group right and left hand 2D: 4D ratios were statistically lower compared to controls and also lower 2D: 4D ratios had association with high ABC scores. When compared with control group, CAH group ABC scores were significantly higher. In KAH group there was a pozitive correlation between 2D: 4D ratios and ABC scores. Conclusion: In light of present study findings, suggest that high androjen may have effect on low 2D: 4D ratios and high ASD symptoms. Further researchs with a large sample are needed in this field.Öğe Autistic Feature and 2D: 4D Finger Ratio Relations Children and Adolescents with Congenital Adrenal Hyperplasia [conferenceObject](Wiley-Blackwell, 2016) Kocaman, Gizem Melissa; Özmerdivenli, Recep; Yektaş, Çiğdem; Arslanoğlu, İlknur; Özdemir, Esra; Bolu, Semih; Erdoğan, Ayten…Öğe Autistic feature and 2D:4D finger ratio relations children and adolescents with congenital adrenal hyperplasia(Cukurova University, Faculty of Medicine, 2017) Kocaman, Gizem Melissa; Özmerdivenli, Recep; Yektaş, Çiğdem; Bolu, Semih; Haskılıç, Yunus Emre; Erdoğan, AytenObjective: Because congenital adrenal hiperplazi (CAH) and autism spectrum sisorders (ASD) is rarely seen, it is difficult to assess whether the increased incidence of ASD in girls with CAH. ASD behaviors and 2D:4D finger ratio changes in patients with androgen overproduction have been reported. The aim of this study is determining the 2D:4D finger ratios and ASD features in girls with CAH and normal control group. Methods: The study group will consist of thirty female children and adolescents between the ages of 3 and 15 who are diagnosed with classic CAH who were followed at the Pediatric Endocrinology Department of Düzce University Medical Faculty Hospital. For the control group, 30 healthy children and adolescents equalized with CAH patients in terms of age and gender will be taken. Al patients and controls examined for psychiatric disorders. by clinicians Patients and control groups filled Autism Behavior Checlist and semistructured sociodemogrphic form that evaluated the gender, age, pregnancy and birth complications, history of mothers’ cigarette and alcohol use. 2D:4D ratios were measured in both of control and CAH groups. Results: KAH group right and left hand 2D:4D ratios were statistically lower compared to controls and also lower 2D:4D ratios had association with high ABC scores. When compared with control group, CAH group ABC scores were significantly higher. In KAH group there was a pozitive correlation between 2D:4D ratios and ABC scores. Conclusion: In light of present study findings, suggest that high androjen may have effect on low 2D:4D ratios and high ASD symptoms. Further researchs with a large sample are needed in this field. © 2017, Cukurova University, Faculty of Medicine. All rights reserved.Öğe Biyotinidaz Eksikliği Şüphesiyle Başvuran Hastaların Klinik Bulguları ve BTD Geni Moleküler Analizi Sonuçları(Duzce University, 2018) Eröz, Recep; Turan, Betül; Doğan, Mustafa; Yüce, Hüseyin; Kocabay, Kenan; Özmerdivenli, RecepAmaç: Biyotinidaz eksikliği, biyotinidaz üretiminden sorumlu biyotinidaz (BTD) genindeki patojenik mutasyonların neden olduğu, geç başlangıçlı biyotine duyarlı multipl karboksilaz eksikliği olarak da bilinen otozomal resesif geçişli bir hastalıktır. Bu çalışmada biyotinidaz eksikliği nedeniyle başvuran hastaların klinik bulgularının ve BTD geni moleküler analizi sonuçlarının literatür eşliğinde sunulması amaçlanmıştır.Gereç ve Yöntemler: Topuk kanı taramasında pozitif olan, nörolojik, duyusal, solunum ve cilt bulguları biyotinidaz eksikliği ile uyumlu olan 9 hasta çalışmaya dahil edilmiştir. Çalışmaya dahil edilen olgulardan genomik DNA izolasyonu için 2 cc periferik kan Etilen Diamin Tetra Asetik Asitli (EDTA) tüplere alınmış ve genomik DNA’ları izole edilerek BTD geninin dizi analizi yapılmıştır.Bulgular: Yapılan BTD geni tüm ekzon dizi analizi sonuçlarına göre 1 hastada homozigot c.1368A>C/p.Gln456His mutasyonu, 1 hastada heterozigot c.1368A>C/p.Gln456His mutasyonu, 1 hastada birleşik heterozigot c.1330G>C/p.Asp444His ve c.511G>A/p.Ala171Thr mutasyonu, 1 hastada birleşik heterozigot c.1336G>C/p.Asp446His ve c.511G>A/p.Ala171Thr mutasyonu, 1 hastada ise heterozigot c.557G>A/p.Cys186Tyr mutasyonu tespit edildi. Dört hastada herhangi bir mutasyon tespit edilmedi.Sonuç: BTD bozukluğu olan hastaların yaşadığı sıkıntıların giderilebilmesi ve gecikme halinde ortaya çıkabilecek komplikasyonların önlenmesi için erken tanı ve tedavi oldukça önemlidir. Hastaya ve aile bireylerine genetik danışmanlık verilerek otozomal resesif kalıtılan hastalık için prenatal tanı veya preimplantasyon genetik tanı yöntemi şansının mevcut olduğu hakkında bilgilendirme yapılması, taşıyıcı ailelerin sağlıklı çocuk sahibi olması açısından önemlidir.Öğe A case with pseudohypoaldosteronism type 1 and investigation of molecular genetic etiology(Duzce University Medical School, 2017) Bolu, Semih; Doğan, Mustafa; Eröz, Recep; Yüce, Hüseyin; Mermerci, Asuman; Özmerdivenli, RecepPseudohypoaldosteronism is a salt-wasting pattern that manifests with hyponatremia, hyperkalemia, and metabolic acidosis, and is the result of aldosterone peripheral nonresponse in renal tubule cells. Peripheral resistance development may occur as a result of mutations in the mineralocorticoid receptor or epithelial sodium channel; it can also develop as a secondary to infection, uropathy and receptor resistance due to drug use. Type 1 PHA is inherited as both autosomal dominant (sporadic-renal form) and autosomal recessive (systemic form). Systemic pseudohypoaldosteronism type 1 is autosomal recessive and the most severe form. Loss of function in one of the three subunits of the epithelial sodium channel (EnaC) is responsible for the disease (the alpha subunit (SCNN1A; 12p13), the beta subunit (SCNN1B; 16p12.2-p12.1), and the Gamma subunit (SCNN1G; 16p12). We present a patient who was diagnosed the primary pseudohypoaldosteronism type 1 for contribution to the literature, which is a rare disease and can be confused with other diseases caused by salt loss. © 2017, Duzce University Medical School. All rights reserved.Öğe Clinical findings and BTD gene molecular analysis results of patients presenting with suspicion of biotinidase deficiency(Duzce University Medical School, 2018) Eröz, Recep; Turan, Betül; Doğan, Mustafa; Yüce, Hüseyin; Kocabay, Kenan; Özmerdivenli, RecepAim: Biotinidase deficiency is an autosomal recessive disease, also known as late-onset biotin-sensitive multiple carboxylase deficiency caused by pathogenic mutations in the biotinidase (BTD) gene responsible for the production of biotinidase. In this study, we aimed to present the clinical findings and BTD gene molecular analysis results in the light of the literature. Material and Methods: Nine patients who were positive in heel blood screening and cases compatible with neurological, sensory, metabolic, respiration and skin findings of biotinidase deficiency were included in the study. For the isolation of genomic DNA from the participants included in the study, 2 cc of peripheral blood was taken into Ethylene Diamine Tetra Acetic Acid (EDTA) tubes and their genomic DNA was isolated and sequence analysis of the BTD gene was performed. Results: According to the all exon sequence analysis results of the BTD gene, homozygous c.1368A>C/p.Gln456His mutation was detected in 1 patient; heterozygous c.1368A>C/p.Gln456His mutation was detected in 1 patient; combined heterozygous c.1330G>C/p.Asp444His and c.511G>A/p.Ala171Thr mutations were detected in 1 patient, combined heterozygous c.1336G>C/p.Asp446His and c.511G>A/p.Ala171Thr were detected in 1 patient, and c.557G>A/p.Cys186Tyr mutation was detected in 1 patient. No mutation was detected in 4 patients. Conclusion: Early diagnosis and treatment are very important for eliminating the problems experienced by patients with BTD disorder and for preventing complications that may occur in case of delay. It is important that informing the patient and family members about the prenatal diagnosis or preimplantation genetic diagnosis method for autosomal recessive inherited disease by giving genetic counseling. © 2018, Duzce University Medical School. All rights reserved.Öğe The Determination of Opinions of Triathlon Athletes on Doping and Anti-Doping Matters(Duzce Univ, 2017) Gündoğdu, Cemal; Evrim, Çelebi; Beyazçiçek, Özge; Beyazçiçek, Ersin; Tüfekçi, Şakir; Özmerdivenli, RecepObjectives: This study aims to determine the knowledge of triathlon athletes on the types of doping used in sports as well as their opinions on the anti-doping matters. Methods: This descriptive study was conducted with 92 individuals participated in Tasucu Triathlon and Istanbul Salcano Triathlon Series, which was organized in 2015 by the Turkish Triathlon Federation. A questionnaire was used to collect data. Chi-square test was used in analysis of the data. Corticosteroids, masking agents, anti-estrogenic agents, beta blockers, and cannabinoids were among the types of doping which were least known by the triathlon athletes. These were followed by peptide hormones, narcotic analgesics, anabolic-androgenic steroids and stimulants. Results: Approximately two thirds of triathlon athletes consider that knowledge of athletes, coaches and administrators on doping is not sufficient. Conclusion: The majority of the athletes participated in the study stated that the relevant institutions and organizations are not fighting against doping adequately.Öğe Doping Types of Athletics Sportsmen and Determination of the Opinions About Anti-Doping(Duzce Univ, 2017) Çelebi, Evrim; Gündoğdu, Cemal; Beyazçiçek, Özge; Beyazçiçek, Ersin; Özmerdivenli, RecepObjective: This research was conducted to determine the level of knowledge of athletics national team athletes about doping types used in sport and their views on anti-doping. Methods: Seven descriptive type studies were conducted with 73 athletes who participating in the Super League Final Competitions and Junior European Champion Club Cup competitions in the Activity Program of the Turkish Athletics Federation and agreeing to participate in the research. Survey form prepared by researchers was used as data collection tool. The data are expressed in numbers and percentages, using the chi-square test in the analysis. Results: 79.5% of the athletes stated that the most stimulants were used in the sport. This was followed by anabolic androgenic steroids with 68.5%, and anti-estrogenic agents with 65.8%. Approximately two-thirds of the athletes said they were well informed about doping by athletes, coaches and administrators (64.4%), and also they had knowledge about it (% 64.4) and had read doping related publications (65.8%). In terms of anti-doping, athlethes find the activities satisfactory of the related institutions and organizations, in particular state (76.7%), federation (82.2%) and clubs (63.0%). Conclusion: As a result, it has been determined that among the participating athletes, the most common types of doping are in which stimulants and anabolicandrogenic steroids, and approximately two-thirds of the athletes said they were well informed about doping by athletes, coaches and administrators, and also think that they had knowledge about it, moreover more than half of the athletes find the activities of the related institutions and organizations satisfactory for the anti-doping.Öğe E-sigaralar: Yeni Bir Fenomen(Düzce Üniversitesi, 2020) Beyazçiçek, Özge; Beyazçiçek, Ersin; Özmerdivenli, Recep; Demir, SerifElektronik sigaralar, geliştirildiğinden beri, tüm dünyada her geçen gün artan bir pazara sahiptir. Günümüzde e-sigara, tütün kullanımı insidansını azaltabilecek yeni bir “tütün” endüstrisini temsil etmektedir. Elektronik nikotin verme sistemi olarak da bilinen elektronik sigaralar minimal bir araçla aerosol haline getirilmiş nikotini vermek üzere tasarlanan cihazlardır. Elektronik sigaraların asıl amacı kullanıcıya sigara içiyor hissini tütün kullanmadan vermektir. E-sigara üreticileri elektronik sigaraları, sigarayı azaltmanın ya da tamamıyla bırakmanın bir yolu olarak pazarlamakla birlikte pek çok kullanıcı, özellikle gençler, e-sigarayı tütün sigarasından daha güvenli olduklarını düşündükleri için tercih etmektedirler. Birçok e-sigara markası marketlerde satılmakta ve bunlara her gün yeni bir tanesi eklenmektedir. Ek olarak, e-sigaralar için birçok farklı tatlandırıcı madde içeren ve birbirinden farklı aromalara sahip çeşitli e-likitler vardır. Bu e-likitlerin ana içerikleri; nikotin, propilen glikol ve bitkisel gliserindir. Çeşitli e-likit içerikleri nedeniyle, e-sigaranın inhalasyondan sonra insan sağlığı üzerindeki etkisi hala belirsizdir. Bu derlemede, e-sigaranın tarihi, çalışma mekanizması, gelişimi ve pazarlaması, bölümleri ve özellikleri, içerdiği maddeler, nikotin ve nikotinin farmakokinetiği, ülkelerin getirdiği düzenlemeler hakkında genel bilgiler ele alınmıştır.Öğe The Effect of Galanin and Exercise on Depression in Rats(Wiley, 2017) Beyazçiçek, Ersin; Mermerci, Asuman; Özmerdivenli, Recep; Beyazçiçek, Özge; Orallar, Hayriye; Sungur, Mehmet Ali…Öğe The Effect of Menstruation on Sports Women's Performance(Kamla-Raj Enterprises, 2016) Özbar, Nurper; Kayapınar, Fatma Çelik; Karacabey, Kürşat; Özmerdivenli, RecepThe aim of this study is to investigate the effect of menstruation cycle on sportswomen performing team sports. In the study, it is practiced an 18-questioned survey to 40 footballer, 40 handball players, 40 volleyball players and 40 basketball players doing sports at a distinguished level being as in total 160 sportswomen related to their menstruation cycle. Frequency and variation analysis is used for the analysis of the data being obtained in the study. Menstruation beginning ages successively 13.02 years, 13.05 years, 13.04 years, and 13.66 years. In all of the athletes normally there is an irregularity with menstruation at a rate of 19.4 percent. It is observed that ten percent of athletes used drug during sports event, 8.8 percent menstruation cycle is painful, 35.6 percent is painless, 55.6 percent is sometimes experienced painful. After menstruation 78.1 percent of athletes stated feeling themselves well. The phase athletes feel themselves the worst is the pre-menstruation phase with the rate of 10.1 percent. During the menstruation phase 19.9 percent of athletes stated that their performance is the same, 2.5 percent stated that better. It is concluded that menstruation cycle does not affect the performance of the athletes taking part in the study.Öğe THE EFFECT OF THYMOQUINONE ON PENICILLIN-INDUCED EPILEPTIFORM ACTIVITY IN RATS(Wiley-Blackwell, 2014) Beyazçiçek, Ersin; Ankaralı, Seyit; Beyazçiçek, Özge; Ankaralı, Handan; Demir, Şerif; Özmerdivenli, Recep…Öğe The Effects of Erythropoietin on the Penicillin Induced Epileptiform Activity in Rats(Kafkas Univ, Veteriner Fakultesi Dergisi, 2016) Bulur, Şule; Demir, Şerif; Bahadır, Anzel; Ankaralı, Seyit; Özmerdivenli, Recep; Beyazçiçek, ErsinErythropoietin (Epo), a cytokine hormone produced in the kidney, promotes the formation of red blood cells in the bone marrow. The penicillin-induced epilepsy model is a commonly used experimental model for epilepsy research. The present study was conducted to elucidate the effect of Epo on penicillin-G (500 IU/2.5 mu l dose, intracortically (i.c)) -induced epileptiform activity in anesthetized adult Wistar-Albino rats (n=39). The animals were randomly divided into four groups as three treatment groups (groups 1-3) and a control group (no drug application). Rats in groups 1, 2 and 3 were intraperitoneally administered 2.000, 4.000 and 6.000 IU Epo/kg, respectively. The effects on penicillin G induced epilepsy were compared across groups using electrocorticography. Epo at 2.000 IU/kg did not cause a significant change (P>0.05) in epileptiform spike-wave activity (number/min) and/or amplitude (mu V) values, whereas the average number of spike-waves per minute and seizure severity decreased significantly in the 4.000 and 6.000 IU/kg Epo groups compared with the control (P<0.05). Consequently, the results of the present study show that administration of Epo has a dose-dependent antiepileptic effect in penicillin induced model of epilepsy in rats.Öğe The Effects of Leptin and Insulin Hormones on Health, Body Fat Percentage of the Endurance Athletes(Kamla-Raj Enterprises, 2014) Karacabey, Kürşat; Yamaner, Faruk; Saygın, Özcan; Özmerdivenli, RecepThe purpose of this study was to compare the effects of the levels of leptin and insulin hormones on body fat percentage of the endurance athletes and sedentary participants. The study was conducted on 37 professional cyclists and 45 sedentary participants aged 21-28 and 19-26 respectively. Mann-Whitney U test and t test were used for statical analyses. There was a statistically significant (p<.05) decrease on the body fat percentage, leptin and insulin levels of the cyclists who were endurance athletes, and a significant difference (p<.05) was found between the glucose and insulin values of the cyclists and the sedentary participants when the pre-and post-test results were compared. It was found that the body fat percentage and leptin values of the sedentary group were high (p<.05) but high density lipoprotein value was low (p<.05). As a result, the data showed that endurance athletes had higher level of the health promoting behavior than sedentary participants. Also, biological extreme of body fat, circulating leptin concentration is closely related to fat content.Öğe The Effects of Swimming Goggles on Intraocular Pressure in Children(Kamla-Raj Enterprises, 2015) Teberik, Kuddusi; Karacabey, Kürşat; Sağlam, Hakan; Özbar, Nurper; Karadenizli, İnci; Özmerdivenli, Recep; Kaya, MuratThe aim of this study is to evaluate the effects of wearing swimming goggles on intraocular pressure in children. The study comprises of 20 eyes from 10 children, 4 male (40%) and 6 female (60%). The median age was 10.4 with a range of 9 to 11 years (mean age was 10.4). Before the study, the height (cm), weight (kg) and intraocular pressure values of children were measured by using two different appliances. Upon the durations of stay in water, 3 different periods were set at 5 minutes, 10 minutes and 20 minutes. Two different eye doctors measured intraocular pressure values of children with specified appliances after the end of each period and then immediately after the goggles were taken off. The average height of the children was 146.5cm ranging from 140 to 163 cm and the average weight was 42.84kg ranging from 33 to 51.6 kg. Before the goggles were worn, the average intraocular pressure value was measured at 16.5 ranging from 12 to 23 mmHg with a tono-pen and at 16.3 ranging from 11 to 22 mmHg with a non-contact tonometer for the right eye, while it was 16.6 ranging from 11 to 21 mmHg with a tono-pen and 16.2 ranging from 11 to 21mmHg with non-contact tonometer for the left eye. At the end of the first period (after 5 minutes), the average intraocular pressure value of right eye was 17.2 (12-23) mmHg measured with a tono-pen and 16.8 (12-23) mmHg measured with a non-contact tonometer, at the end of second period values were 17.0 (10-23) mmHg and 17.3 mmHg, respectively, at the end of the third period the values were 17.30 (13-24) mmHg and 17.60 (12-24) mmHg, respectively. The average intraocular pressure values of the left eye were 16.7 (11-22) mmHg and 16.3 (10-24) mmHg, respectively, at the end of second period values were 16.7 (1025) mmHg, 16.6 (11-23) mmHg, respectively, and at the end of the third period the values were 17.70 (13-24), 17.10 (12-23) mmHg, respectively. The researchers considered that patients with glaucoma and suspected glaucoma should use well fitting swimming goggles, which do not have overly tightened straps and a small rim diameter.Öğe Effects of thymoquinone, the major constituent of Nigella sativa seeds, on penicillin-induced epileptiform activity in rats(Riyadh Armed Forces Hospital, 2016) Beyazçiçek, Ersin; Ankaralı, Seyit; Beyazçiçek, Özge; Ankaralı, Handan; Demir, Şerif; Özmerdivenli, RecepObjective: To investigate the effects of thymoquinone (TQ) in a penicillin-induced epilepsy model in rats. Methods: This experimental study included 56 adult male Wistar rats. Experiments were performed in the Research Laboratory of the Department of Physiology, Medical School, Duzce University, Duzce, Turkey, between October 2013 and December 2014. Animals were divided into the following 7 groups: sham, control, only thymoquinone, vehicle (Dimethylsulfoxide), and doses of 10, 50, and 100 mg/kg of TQ. After rats were anesthetized, the left part of the skull was removed. A pair of silver/silver chloride electrodes was placed on the somatomotor area, and electrocorticographic recording was started. After 5 minutes basal activity was recorded, and TQ was applied intraperitoneally. At the thirtieth minute after TQ, epileptiform activity was induced by intracortical penicillin. The first spike latency, spike frequency, and the amplitude of epileptiform activity were analyzed statistically. Results: The different doses of TQ significantly increased the latency time to onset of first spike wave, and decreased the frequency, and amplitude of epileptiform activity in the first 20 minutes compared with the control group. Conclusion: Thymoquinone shows potential as an antiepileptic drug resulting from its effects of prolonged latency time, and reduced spike wave frequency and amplitude of epileptiform activity.
