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Öğe Akut İnfantil Hemorajik Ödem Kliniğinin Seyri: İki Olgu Sunumu(Aves, 2019) Kılıçaslan, Önder; Yıldız, Refika; Engin, Muhammet Mesut Nezir; Büyük, Nursel; Temizkan, Ramazan Cahit; Özlü, Emin; Kocabay, KenanAkut infantil hemorajik ödem genellikle 4 ile 24 ay arasında ve kış aylarında görülen ekimotik purpurik döküntü ve subkutan ödem ile karakterize iyi huylu bir hastalıktır. Ancak korkutucu görünümü nedeniyle aileyi ve hekimleri endişeye sevk etmekte, gereksiz tetkik ve tedaviye neden olmaktadır. Olgularımız ile akut infantil hemorajik ödemin klinik seyri ve prognozu hakkında bilgi vermeyi amaçladıkÖğe Alteration of tissue expression of human beta defensin-1 and human beta defensin-2 in psoriasis vulgaris following phototherapy(Taylor & Francis Ltd, 2019) Uzunçakmak, Tuğba Kevser; Karadağ, Ayşe Serap; Özkanlı, Şeyma; Akbulak, Özge; Özlü, Emin; Akdeniz, Necmettin; Oğuztüzün, SerpilWe compared the expression profiles of antimicrobial peptides (AMPs) in psoriatic skin before and after narrow band ultraviolet B (nb-UVB) phototherapy and compared the levels to healthy controls. We studied 15 male and 12 female patients with psoriasis vulgaris, and 11 female and nine male control individuals. The patient group was treated with 24-36 sessions of nb-UVB phototherapy. Immunohistochemical staining for human beta defensin 1 (hBD-1) and human beta defensin 2 (hBD-2) expression of lesioned and control skin was performed prior to and following phototherapy. After phototherapy, the psoriatic area and severity index (PASI) decreased significantly in the treated patients compared to controls. The hBD-1 level was significantly higher in psoriasis patients than healthy controls. We found no statistically significant difference in hBD-1 and hBD 2 levels before and after phototherapy in the patient group. Although hBD-1 plays a role in psoriasis, levels of human beta defensin 1 and 2 are not affected significantly by phototherapy.Öğe An Overview of Etiopathogenesis of Acne Vulgaris(Düzce Üniversitesi, 2018) Özlü, Emin; Baykan, Ayşegül; Ertaş, RagıpAcne vulgaris is a chronic inflammatory disease that primarily affects the pilosebase unit. Acne vulgaris remains one of the commonest diseases to afflict humanity, with prevalence up to 90% during adolescence. Relatively little is known about its epidemiology despite the fact that acne is a universal condition in younger population. This disease is more common in developed countries than in less industrialized regions of the world. The etiopathogenesis of acne is multifactorial. Sebum production, follicular epithelial keratinization, bacterial proliferation, and inflammation play significant role in etiopathogenesis. Recent studies shown that toll like receptors and antimicrobial peptides play a role in the pathogenesis of acne vulgaris. The relationship between diet and acne is highly controversial. Strong evidence shows that high glycemic loads diet may exacerbate acne. In addition, the factors contributing to the formation of acne also include genetic predispositions, hormonal abnormalities, psychological, environmental and iatrogenic factors. The disease is mainly observed face, chest, back and shoulders. When acne is untreated, it may cause social isolation, difficulty in finding jobs, depression and suicide attempt as a result of emotional and physical scar formation. In this article, the epidemiology and etiopathogenesis of acne are overviewed.Öğe Behçet disease: New developments in the etiopathogenesis of an old silk road disease(Pulse Marketing and Communications LLC, 2018) Özlü, Emin; Karadağ, Ayşe SerapBehçet disease (BD) is a systemic inflammatory disorder that affects the skin, mucosa, eyes, joints, blood vessels, brain, and gastrointestinal tract. The etiopathogenesis of BD has not yet been fully elucidated, but disorganized immune responses against the stimuli of environmental triggering factors have been considered to play a major role in the pathogenesis of the disease in individuals with genetic susceptibility. Human leukocyte antigen (HLA)-B*51 is known to be the main factor involved in genetic susceptibility to BD. Among the environmental factors, infectious agents in particular are thought to be important. Immunological abnormalities could thus be the cornerstone in the development of BD. Along with cytokines that play a role in disease pathogenesis, numerous other cytokines have been recently identified or have been the focus of recent studies. This contribution sheds light on the etiopathogenesis and immunology of BD in relation to the current literature. © 2018 Pulse Marketing & Communications, LLC.Öğe Can Numeric Maturation Value Be Used as a Prognostic Indicator and Diagnostic Tool in Cutaneous Melanomas? A Morphometric Study(Sci Printers & Publ Inc, 2019) Gamsızkan, Mehmet; Büyücek, Şeyma; Coşkun, Sinem Kantarcıoğlu; Sungur, Mehmet Ali; Özlü, Emin; Bahçıvan, Atike; Önal, BinnurOBJECTIVE: Some melanocytic lesions can be difficult to diagnose because of ambiguous histological and immunohistochemical features. Morphometric features of melanocytes in the upper and lower parts of a challenging lesion may help to facilitate an accurate diagnosis. STUDY DESIGN: We studied 32 cases of invasive cutaneous melanoma, 35 cases of mild or moderate dysplastic nevus, and 31 cases of benign melanocytic nevus. All cases were immunostained with Sox10. The nuclear areas of 30 melanocytes were measured on each papillary (upper al1) dermis and reticular dermis/subcutaneous tissue (lower ILI) in all cases by using the Image J analysis program. Then, a maturation index (U/L) was calculated for each case. Also, cutaneous melanomas were categorized into 2 groups that displayed pseudo-maturation or the lack of it. RESULTS: Mean maturation index was 1.04 +/- 0.29 in melanomas, 1.23 +/- 0.28 in dysplastic nevi, and 1.52 +/- 0.33 in benign melanocytic nevi, respectively. There were statistically significant differences between melanoma and dysplastic nevus (p = 0.012) and between melanoma and benign melanocytic nevus (p < 0.001) for the maturation index. Although pseudo-maturation was associated with low mitotic activity and thin Breslow thickness, there was no significant difference between survival distributions of 2 melanoma groups. CONCLUSION: Calculation of the maturation index can be used as a supporting tool for the differential diagnosis of challenging cases. However, it may possess limitation for evaluation of nevoid melanoma, melanoma in situ, or clonal nevus.Öğe Can numeric maturation value be used as prognostic indicator and diagnostic tool in cutaneous melanomas (a morphometric study)?(Springer, 2018) Gamsızkan, Mehmet; Büyücek, Şeyma; Coşkun, Sinem Kantarcıoğlu; Sungur, Mehmet Ali; Özlü, Emin; Bahçıvan, Atike; Önal, Binnur…Öğe Case Report: Lupoid cutaneous leishmaniasis mimicking verruca plana(Faculty of 1000 Ltd, 2017) Özlü, Emin; Baykan, Ayşegül; Yaman, Ozan; Ertaş, Ragıp; Atasoy, Mustafa; Özyurt, Kemal; Taşlıdere, NazanCutaneous leishmaniasis (CL) is an infectious disease caused by various species of leishmania protozoan parasites. Lupoid CL is a rare form of CL that has a stunning similarity to other granulomatous cutaneous conditions of infectious or inflammatory origin. Verruca plana, also known as a "flat wart", is a benign proliferation of the skin resulting from infection with human papilloma virus (HPV). Herein, we presented a case of lupoid CL mimicking verruca plana on the face. © 2017 Ozlu E et al.Öğe Case Report: Nicolau syndrome due to etofenamate injection(Faculty of 1000 Ltd, 2017) Özlü, Emin; Baykan, Ayşegül; Ertaş, Ragıp; Ulaş, Yılmaz; Özyurt, Kemal; Avcı, Atıl; Baykan, HalitNicolau syndrome, also known as embolia cutis medicomentosa, is a rare complication characterized by tissue necrosis that occurs after injection of drugs. The exact pathogenesis is uncertain, but there are several hypotheses, including direct damage to the end artery and cytotoxic effects of the drug. Severe pain in the immediate postinjection period and purplish discoloration of the skin with reticulate pigmentary pattern is characteristic of this syndrome. Diagnosis is mainly clinical and there is no standard treatment for the disease. Etofenamate is a non-steroidal anti-inflammatory drug and a non-selective cyclooxygenase inhibitor. Cutaneous adverse findings caused by etofenamate are uncommon. Herein, we present a case with diagnosis of Nicolau syndrome due to etofenamate injection, which is a rare occurrence. © 2017 Ozlu E et al.Öğe Comparison of cutaneous manifestations in diabetic and nondiabetic obese patients: A prospective, controlled study(Kare Publ, 2018) Özlü, Emin; Uzunçakmak, Tuğba Kevser; Takır, Mümtaz; Akdeniz, Necmettin; Karadağ, Ayşe SerapOBJECTIVE: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group. METHODS: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. The number of diabetic obese patients was 138 (30%), whereas that of nondiabetic obese patients was 312 (70%). A detailed dermatological examination was performed for each case, and accompanying dermatoses were compared. RESULTS: The mean body mass index (BMI) in the obese patients and control group was 37.22 kg/m(2) and 22.23 kg/m(2), respectively. The most common dermatoses in the obese patients were, according to their frequency: striae distensae (291 patients, 64.7%), acrochordon (236 patients, 52.4%), acanthosis nigricans (213 patients, 47.3%), plantar hyperkeratosis (209 patients, 46.4%), and venous insufficiency (202 patients, 44.9%). Although hirsutism was more frequently observed in the nondiabetic obese group than in the diabetic obese group, stasis dermatitis was less frequently observed (p<0.05). CONCLUSION: We found that many dermatoses are more frequently observed in the obese patients than in the controls. We observed that the effect of obesity on skin is different from that of diabetes mellitus and that cutaneous manifestations of obesity occur more frequently. More extensive, comprehensive, and advanced studies on this subject are required.Öğe Correlation study between clinical classification and disability index in a holistic evaluation of acne severity and impact in Turkey(Edizioni Minerva Medica, 2021) Özlü, Emin; Karadağ, Ayşe Serap; Aksoy, Berna; Bilgili, Serap Güneş; Gönül, Müzeyyen; Yavuz, İbrahim H.; Şenel, EnginBACKGROUND: This study provides a comparison between disease severity observed by inspectors and the disease burden assessed by patients is scanty in acne study. METHODS: In a multicenter prospective hospital-based study, modified Comprehensive Acne Severity Scale (mCASS) and Cardiff Acne Disability Index (CADI) were employed to grade disease severity and to determine the quality of life, respectively. The average of the mCASS and CADI scores, with range at 0-25, was termed as Acne Severity and Impact Grading System (ASIG). RESULTS: In 1331 evaluated patients (mean: 21,51 +/- 4,93 years), including 306 men and 1025 women, an overall significant, positive correlation was found between ASIG and mCASS (r=0.862), or CADI (r=0.686), respectively (P=0.001 each). Adult women with back acne and adolescent with decollete expressed greater concern (higher CADI) than the clinical severity (lower mCASS). The overall prevalence of acne in decollete area, including neck, was 32.3%. CONCLUSIONS: Discrepancies in the acne severity between self-perception and objective evaluation exist in certain subgroups of patients. Decollete acne deserves special attention in clinical assessment. (Cite this article as: Ozlu E, Karadag AS, Aksoy B, Gunes Bilgili S, Gonul M, Yavuz IH, et al. Correlation study between clinical classification and disability index in a holistic evaluation of acne severity and impact in Turkey. Ital J Dermatol Venereol 2021;156:669-74. DOI: 10.23736/S27848671.20.06738-3)Öğe Cutaneous manifestations of diabetes mellitus and the metabolic syndrome(Elsevier Science Inc, 2018) Karadağ, Ayşe Serap; Özlü, Emin; Lavery, Michael JosephMetabolic diseases are commonly encountered in the Western world. Cutaneous manifestations are common in metabolic disorders, such as diabetes mellitus (DM) and the metabolic syndrome (MetS), and metabolic diseases may manifest with specific skin findings. MetS and DM share a common mechanism in their etiopathogenesis. As a result, the skin findings associated with these two diseases partially overlap. Several skin findings in DM and MetS may be the first clinical features of the disease, and early diagnosis facilitates treatment, thereby helping in preventing long-term complications. In this review, MetS and skin manifestations associated with DM are discussed. (C) 2018 Elsevier Inc. All rights reserved.Öğe Dermatoloji Kliniği Alerji Ünitesinde Yapılan Deri Prick Testi Sonuçları(2020) Özyurt, Kemal; Ertaş, Ragıp; Özlü, Emin; Akkuş, Muhammet Reşat; Avcı, Atıl; Atasoy, MustafaAmaç: Deri prick testi (DPT) başlıca atopik dermatit (AD), kronik ürtiker (KÜ),alerjik astma (AA), ve alerjik rinit (AR) gibi hastalıkların tanı ve takibindekullanılmaktadır. Bu çalışmanın amacı, Dermatoloji Kliniği Alerji Ünitesi(DKAÜ)'nde yapılan DPT sonuçlarının geriye dönük olarak incelenerek,endikasyonları ve pozitiflik oranlarının araştırılmasıdır.Gereç ve Yöntem: DKAÜ arşivi kullanılarak 2014-2016 yıllarında yapılan DPTsonuçları incelenmiştir. DPT sonuçları, her hasta için ayrıca arşivlenen DPT formlarıokunarak yapılmıştır.Bulgular: DKAÜ'nde 2014-2016 yılları arasında 1916 hastaya DPT yapılmıştır. Buhastaların 941'inde AA, 133'ünde AR, 842'sinde dermatolojik hastalık olduğugörülmüştür. En az bir ve birden fazla alerjen madde ile DPT pozitiflik oranı, sırasıylaAA, AR ve dermatolojik hastalıklarda; %92.1, %71.4 ve %50 olarak saptanmıştır.Dermatolojik hastalıklar incelendiğinde, 69 kronik ürtiker (KÜ), 55 atopik dermatit(AD) hastası haricinde, geriye kalan 718 hastada, başlıca dermatit, idiopatikgeneralize pruritus (İGP) olmak üzere farklı dermatolojik hastalıkların olduğugörülmüştür. DPT pozitifliği KÜ’de %55.1, AD’te %52.7 ve diğer dermatolojikhastalıklarda %48.6 olarak saptanmıştır.Sonuç: Bu çalışmanın sonuçlarına göre DPT pozitiflik oranı, AR ve AA hastalarındahem KÜ ve AD hem de diğer dermatolojik hastalıklara göre daha yüksektir. Bununnedeni, KÜ ve AD etyopatogenezinde tip 1 aşırı duyarlılık reaksiyonlarının rolünündaha az olması ve/veya farklı dermatolojik tanılarla yönlendirilen hastalarda doğruolmayan DPT endikasyonları olabilir.Öğe Dermatopathological Correlation of Clinically Challenging Cutaneous Lesions: a Single Center Experience of 2184 Cases(Mattioli 1885, 2022) Özcan, Yunus; Özlü, Emin; Karagün, Ebru; Uyar, Belkız; Gamsızkan, MehmetIntroduction: Although a trained eye can easily identify typical skin lesions, histopathological exam-ABSTRACT ination and clinicopathological correlation are critical in challenging cases. Objectives: The primary objective is to organize the final diagnoses reached following clinicopathological consensus in clinically challenging cutaneous lesions, identifying the most common diagnostic scenarios encountered by dermatopathologists and discussing their diverse differentials submitted by clinicians. The secondary objective is to investigate how the case profile and clinician decision-making processes evolved during the COVID-19 pandemic. Methods: Skin and mucosa samples collected by the dermatology department between 2016 and 2020 were classified based on pathology reports. For frequent diagnoses, preliminary diagnoses stated by clinicians on pathology requisition forms were reviewed. The years preceding and following the first nationally reported COVID-19 case were compared to investigate the pandemic’s impact on the distribution of dermatology and dermatopathology cases. Results: One thousand nine hundred and eighty-nine reports were classified into 4 major categories: inflammatory (49.8%), neoplastic (30.1%), other diseases (7.1%), and non-diagnostic (12.8%). We further classified inflammatory diseases based on major tissue reaction patterns and neoplasms based on cell origin. We analyzed the leading diagnoses in each category, discussed their differential diagnoses, and provided clinicians with clues to reduce errors in practice. Following the pandemic, the overall number of pathology reports and patient admissions dropped dramatically, with significant changes in case profiles. Conclusions: We presented and discussed the frequently encountered confounding cases to sketch the diagnostic landscape. In the authors’ experience, clinicopathological correlation can increase the rate of reaching the diagnosis by up to 75.3%. © 2022 Ozcan et al.Öğe Effect of low-dose acitretin treatment on pituitary hormones in psoriasis vulgaris: A retrospective study(Wolters Kluwer Medknow Publications, 2019) Karadağ, Ayşe Serap; Özlü, Emin; Köstek, Osman; Bilgili, Serap Güneş; Balaharoğlu, Ragıp; Ertuğrul, Derun TanerBackground: It has been reported that retinoids may lead to hormonal alterations. Aim: In this retrospective study, we aimed to study the effect of acitretin on pituitary hormones in psoriasis patients. Methods: Out of 50 patients intended to be studied, blood samples of 43 patients could be tested before and after 3 months of acitretin therapy (0.2 to 0.5 mg/kg/day). Results: Patients mean +/- standard deviation ages and female/male ratio were 46 +/- 17 years and 19/24, respectively. After treatment with acitretin, gamma-glutamyltransferase, alkaline phosphatase, total cholesterol and triglyceride levels increased significantly (P < 0.05). After treatment, total protein, free thyroxine (T4) levels decreased significantly (P < 0.05). No significant differences were observed between before-after acitretin treatment regarding pituitary hormone levels in psoriasis patients (P > 0.05). Limitations: The retrospective nature of the study, inability to retest blood samples of 7 patients at 3 months post treatment, low dose and short duration of acitretin treatment were limitations of this study. Conclusion: This study showed that pituitary hormones were not affected except free T4 (thyroid hormone) by acitretin treatment. Further experimental and clinical studies are needed to clarify the effect of acitretin on pituitary hormones.Öğe Effect of pulse corticosteroids and low dose methotrexate in cases of treatment-resistant lichen sclerosus(Elsevier Taiwan, 2018) Karadağ, Ayşe Serap; Akdeniz, Necmettin; Özlü, Emin; Süslü, Hülya; Uzunçakmak, Tuğba Kevser; Bozdağ, Halenur; Kavala, Mukaddes…Öğe Effects of Different Doses of Systemic Isotretinoin on Eyes: A Histopathological and Immunohistochemical Study in Rats(NLM (Medline), 2020) Karadağ, Remzi; Karadağ, Ayşe Serap; Özlü, Emin; Oğuztüzün, Serpil; Şimşek, Gülçin; Esmer, Oktay; Bilgili, Serap GüneşPURPOSE: To evaluate ocular side effects associated with systemic isotretinoin histopathologically. METHODS: In this multicenter study, a total of 15 male and 15 female rats were randomly divided into 3 equal groups according to the oral dose of isotretinoin they were administered: 0 mg/kg/d (group A), 7.5 mg/kg/d (group B), and 15 mg/kg/d (group C). Biopsy specimens were taken from the globe conjunctiva, cornea, and eyelid conjunctiva. Expression levels of human beta-defensin-1, human beta-defensin-2, toll-like receptor (TLR)-2, and TLR-4 were evaluated by immunohistochemical methods. RESULTS: The number of goblet cells in eyelid conjunctiva was significantly lower in group B than that in group A and group C (P = 0.002). The sizes of meibomian gland acini were significantly smaller in group B and group C than those in group A (P < 0.001). Fibrosis of eyelid conjunctiva was significantly higher in group C and group B than that in group A (P = 0.002). The levels of staining of TLR-4 in the cornea with group B were significantly lower compared with group C (P = 0.035). CONCLUSIONS: Our study suggests that isotretinoin in the early period affects eyelid conjunctiva and meibomian glands without affecting the globe conjunctiva and cornea. Occurrence of the initial symptoms of isotretinoin on the eyelids, especially on the meibomian glands, suggests that the symptoms of patients occur because of evaporative dry eye.Öğe Effects of Isotretinoin Treatment on Sleep and Quality of Life in Patients with Acne Vulgaris(Duzce Univ, 2018) Özlü, Emin; Ertaş, Ragıp; Özyurt, Kemal; Karaatlı, İsmail; Karadağ, Ayşe SerapObjective: We aimed to investigate the effect of isotretinoin treatment on sleep and quality of life in patients with AV. Methods: 109 total patients who identified as 66 AV patients attended the dermatology outpatient clinic and started isotretinoin treatment, and 43 healthy controls, were enrolled in the study. Pittsburgh Sleep Quality Index (PSQI), short form-36 (SF-36), and Global Acne Grading System (GAGS) were administered to all patients twice; before and two months after the treatment. The results were compared with the healthy control group. Results: The pretreatment physical health scores of the patients were significantly higher than the healthy controls. No significant differences were observed between before-after isotretinoin treatment regarding physical and mental health scores in AV patients. While there were no significant differences between the pretreatment and healthy control group in terms of total PSQI scores; the scores of sleep duration were significantly lower in the pretreatment group. No significant differences were observed between before-after isotretinoin treatment regarding total PSQI and subcomponent scores in AV patients. There was a statistically significant negative correlation between pre- and post-treatment total PSQI scores and physical, mental health scores in patients with AV. Conclusion: Results of the present study suggest that isotretinoin therapy does not affect the sleep quality in patients with AV. The impairment of sleep quality negatively affects the quality of life in patients with AV. More comprehensive studies assessing the effect of isotretinoin treatment on sleep quality are needed.Öğe Evaluation of ocular findings in patients with lichen planus(Termedia Publishing House Ltd, 2019) Özlü, Emin; Teberik, KuddusiIntroduction: Lichen planus (LP) is a chronic, inflammatory disease of unknown etiology. Aim: To evaluate the tear functions and the retinal and choroidal thickness (CT) in patients with LP. Material and methods: In total, 33 patients and 30 healthy controls were enrolled. All participants were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer 1 test (with anesthesia), tear break-up time (TBUT) test, intraocular pressure (IOP), axial length (AL), and central corneal thickness (CCT). The measurements of retinal thickness (RT) and CT were obtained by spectral domain optical coherence tomography. Results: No significant difference was observed between the groups in IOP, AL, CCT, or RT (p > 0.05 in each group). There was a significant difference in the Schirmer 1 test, TBUT, and OSDI questionnaire (p < 0.05 in each group). Choroidal thickness in LP patients was thinner than that in the controls (p = 0.001 in each location). There was a moderate negative correlation between the disease duration and Schirmer 1 test, TBUT, and subfoveal CT (r = -0.426, r = -0.555, r = -0.637; p = 0.001, p = 0.001, p = 0.001, respectively). There was a moderate negative correlation between the oral mucosal involvement and Schirmer 1 test, TBUT, and subfoveal CT (r = -0.345, r = -0.392, r = -0.467; p = 0.006, p = 0.001, p = 0.001, respectively). There was a positive correlation between disease duration, oral mucosal involvement and OSDI score (r = 0.717, r = 0.345; p = 0.001, p = 0.006, respectively). Conclusions: Lichen planus may influence tear function tests and may cause dry eye. Patients with LP had lower CT values than healthy controls. Further studies are needed to clarify the effect of LP on the eyes.Öğe Evaluation of platelet parameters and neutrophil/lymphocyte ratio during omalizumab treatment in patients with severe chronic spontaneous urticaria(Tubitak Scientific & Technical Research Council Turkey, 2018) Ertaş, Ragıp; Özyurt, Kemal; Karakükçü, Çiğdem; Akkuş, Muhammet Reşat; Özlü, Emin; Avcı, Atıl; Atasoy, MustafaBackground/aim: Spontaneous wheals and/or angioedema lasting longer than six weeks are described as chronic spontaneous urticaria (CSU). Omalizumab is used for the treatment of antihistamine-resistant CSU. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW) are considered important indicators of inflammation and platelet activation in chronic diseases. We aimed to determine the NLR, PLR, MPV, and PDW levels in patients with CSU compared with healthy controls. We also aimed to investigate the effects of omalizumab therapy on these parameters in CSU patients. Materials and methods: This hospital-based, retrospective study included 143 patients with CSU and 132 healthy controls with a mean age of 40.0 +/- 13.17 and 42.0 +/- 16.34, respectively. Patients with equal or higher-than-baseline UAS scores at week 12 of omalizumab treatment were considered nonresponders, others were considered responders. We analyzed the neutrophils, lymphocytes, platelet counts, NLR, PLR, MPV, and PDW before, during, and after omalizumab treatment and compared the results with those of healthy controls. Results: CSU patients presented higher baseline MPV (P = 0.035) and lower baseline PDW values (P < 0.001) than healthy controls. There were statistically significant increases in the MPV (P < 0.001), MPV/platelet count (P = 0.005), and PDW (P = 0.003) and there was a statistically significant decrease in the NLR (P = 0.018) during omalizumab treatment. The percent increase of MPV was low in nonresponders (P = 0.009). Nonresponders had lower PDW values than responders (P = 0.040). Conclusion: The increase in the MPV and PDW may be due to platelet activation during omalizumab treatment. The decrease in the NLR may be regarded as an antiinflammatory effect of omalizumab. The effect of omalizumab on platelet and inflammatory markers may be used to discriminate the responders from nonresponders.Öğe Morphea secondary to interferon betai B injection: A case and review of the literature(Dermatology Online Journal, 2019) Özlü, Emin; Karadağ, Ayşe Serap; Akdeniz, Necmettin; Uzunçakmak, Tuğba Kevser; Zemheri, Ebru; Özkanlı, ŞeymaInterferon beta (IFNß) is a drug used successfully in the treatment of multiple sclerosis (MS). Although IFNß is a safe and well-tolerated drug, dermatological side effects are common. The most common dermatological adverse effect is a local reaction at the injection site. It may also cause inflammatory and immune-mediated dermatological side effects. However, morphea induced by IFNßlb injection is very rare. © 2019, Dermatology Online Journal. All rights reserved.
