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Öğe Anti-genotoxic Effects of Schiff bases and their Mn(III) Complexes Containing L-Aspartic acid and L-Phenylalanine(Gazi Univ, 2018) Özkan, Elvan Hasanoğlu; Kızıl, Hamit Emre; Şakıyan, İffet; Nartop, Dilek; Sarı, Nurşen; Ağar, GülerayThe purpose of the research was to evaluate the genotoxic and anti-genotoxic properties of Schiff bases and their Mn (III) complexes containing L-aspartic acid, and L-phenylalanine. The anti-genotoxic properties of four compounds in human lymphocytes cells were investigated by sister chromatid exchanges (SCEs) test system against aflatoxin Bi (AFBi). The results showed that compounds have strong anti-genotoxic properties.Öğe Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases(2020) Nartop, Dilek; Özkan, Elvan Hasanoğlu; Kızıl, Hamit Emre; Ağar, Güleray; Sarı, NurşenIn this work, Ni(II) complexes with unsymmetric Schiff bases (NiL1, NiL2, NiL3, NiL4) were prepared by a twostage method reported by one of us recently for investigate antimutagenic properties. Sodium azide-inducedantimutagenic effect in lymphocytes was determined by sister chromatid exchange (SCE) and micronucleus (MN)methods. It has been determined that the synthesized compounds have antimutagenic properties and reduce themutagenicity caused by sodium azide (NaN3) which is used as a positive control.Öğe New Antimicrobial Polymeric Microspheres Containing Azomethine(Springer, 2022) Ülke, Eyüp; Özkan, Elvan Hasanoğlu; Nartop, Dilek; Ogutcu, HaticeHerein, new polymeric microspheres containing azomethine (PS-OPA, PS-OPA-Pt, PS-OPA-Ni, PS-OPA-Mn and PS- OPA-Cu) were synthesized and investigated by elemental analysis, FT-IR, SEM-EDX, TGA-DTA, UV-Vis, GPC and magnetic susceptibility. Antibacterial and antifungal activities of the synthesized polymeric microspheres were evaluated against pathogenic bacteria (Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Staphylococcus aureus ATCC25923, Enterobacter aerogenes, Pseudomonas aeroginosa sp., Klebsiella pneumonia ATCC27853, Salmonella type H NCTC9018394, Proteus vulgaris RSKK96026, Escherichia coli ATCC1280) and yeast (Candida albicans Y-1200-NIH) by the well-diffusion method for potential biomedical applications. It was determined that polymeric microspheres exhibited higher inhibition effect against B. cereus, E. aerogenes, P. aeruginosa, P. vulgaris and showed higher antifungal activity than standard nystatin. [GRAPHICS] .Öğe Novel polymeric microspheres: Synthesis, enzyme immobilization, antimutagenic activity, and antimicrobial evaluation against pathogenic microorganisms(John Wiley and Sons Inc., 2020) Nartop, Dilek; Demirel, Birtane; Güleç, Murat; Özkan, Elvan Hasanoğlu; Yetim, Nurdan Kurnaz; Sarı, Nurşen; Ağar, GülerayNew polymeric microspheres containing azomethine (1a-1c and 2a-2c) were synthesized by condensation to compare the enzymatic properties of the enzyme glucose oxidase (GOx) and to investigate antimutagenic and antimicrobial activities. The polymeric microspheres were characterized by elemental analysis, infrared spectra (FT-IR), proton nuclear magnetic resonance spectra, thermal gravimetric analysis, and scanning electron microscopy analysis. The catalytic activity of the glucose oxidase enzyme follows Michaelis-Menten kinetics. Influence of temperature, reusability, and storage capacity of the free and immobilized glucose oxidase enzyme were investigated. It is determined that immobilized enzymes exhibit good storage stability and reusability. After immobilization of GOx in polymeric supports, the thermal stability of the enzyme increased and the maximum reaction rate (Vmax) decreased. The activity of the immobilized enzymes was preserved even after 5 months. The antibacterial and antifungal activity of the polymeric microspheres were evaluated by well-diffusion method against some selected pathogenic microorganisms. The antimutagenic properties of all compounds were also examined against sodium azide in human lymphocyte cells by micronuclei and sister chromatid exchange tests. © 2019 Wiley Periodicals, Inc.Öğe Synthesis, antimicrobial and antimutagenic effects of novel polymeric-Schiff bases including indol(Elsevier Science Bv, 2019) Nartop, Dilek; Özkan, Elvan Hasanoğlu; Gündem, Mehmet; Çeker, Selçuk; Ağar, Güleray; Öğütcü, Hatice; Sarı, NurşenHerein, the synthesis and characterization of three new polymeric-Schiff bases including indol (L-1, L-2, L-3) were reported. The antibacterial and antifungal activity of all compounds were investigated by the well-diffusion method against some selected microorganisms as potential antimicrobial agents. In addition, the anti-genotoxic properties of these polymeric-Schiff bases were examined against sodium azide in human lymphocyte cells by micronuclei (MN) and sister chromatid exchange (SCE) tests. (C) 2019 Elsevier B.V. All rights reserved.Öğe Yeni Tiyazol Bazlı Tiyosemikarbazon Komplekslerinin Sentezi ve in vitro Biyolojik Değerlendirmeleri(Duzce University, 2024) Nartop, Dilek; Özkan, Elvan Hasanoğlu; Öğütçü, Hatice; Yetim, Nurdan KurnazSunulan bu çalışmada, yeni heterosiklik tiyazol bazlı tiyosemikarbazon Ag(I) kompleksleri (Hc1, Hc2, Hc3) template yöntem ile elde edildi. Sentezlenen tiyosemikarbazon bileşiklerinin yapıları bazı spektroskopik teknikler (element analizi, infrared spektra (IR), termogravimetrik analiz (TGA), organic elemental analiz, ve magnetik duyarlılık ölçümleri) ile karakterize edildi. Yeni heterosiklik tiyazol bazlı tiyosemikarbazon Ag(I) komplekslerinin biyolojik aktiviteleri potansiyel antimikrobiyal ajanlar olarak seçilmiş hastalık yapıcı patojenlere (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteusv vulgaris RSKK96026, Candida albicans Y-1200-NIH) karşı in vitro olarak incelendi.
