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Öğe A Case of Familial Mediterranean Fever Who Was Presented with Acute Coronary Syndrome(Düzce Üniversitesi, 2009) Ordu, Serkan; Kaya, Ahmet; Aydın, Mesut; Dindar, Gökhan; Özhan, Hakan; Yazıcı, MehmetFamilial Mediterranean fever is an autosomal recessive disease manifested by recurrent attacks of peritonitis, plevritis and arthritis, and characterized by clinical, histological and laboratory evidence for localized and systemic inflammation. Systemic inflammation is an important factor in the initiation and development of atherosclerosis. We report here a patient with long-standing FMF who was presented with acute coronary syndrome during the febrile attacksÖğe Abnormal ECG Findings In Turkish Adults: An Epidemiologic Observational Study(Elsevier Science Inc, 2013) Karabacak, Ahmet; Türker, Yasin; Tibilli, Hakan; Türker, Yasemin; Albayrak, Sinan; Ekinözü, İsmail; Özhan, Hakan…Öğe Acute coronary stenosis in a young man with Behcet's syndrome(Karger, 2008) Erbilen, Enver; Albayrak, Sinan; Gülcan, Erim; Taşer, Figen; Bulur, Serkan; Özhan, Hakan; Yazıcı, MehmetObjective: To present a case of myocardial infarction due to Behcet's syndrome. Clinical Presentation and Intervention: A 27-year-old man who was known to have Behcet's syndrome for 1 year presented with retrosternal fluctuating chest pain, which radiated to the epigastrium 5 h prior to admission. Coronary angiography showed total occlusion of the left anterior descending coronary artery, which was successfully treated with coronary stent implantation. Conclusion: This case shows that patients with Behcet's syndrome who had acute chest pain should be thoroughly examined for any signs of acute myocardial infarction. Copyright (C) 2008 S. Karger AG, Basel.Öğe Acute coronary syndrome and sildenafil - coincidence or coexistence: Author reply(W B Saunders Co-Elsevier Inc, 2014) Ekinözü, İsmail; Aslantaş, Yusuf; Tibilli, Hakan; Türker, Yasin; Özhan, Hakan…Öğe Acute myocarditis mimicking acute myocardial infarction associated with pandemic 2009 (H1N1) influenza A virus(Via Medica, 2011) Erden, İsmail; Erden, Emine Çakcak; Özhan, Hakan; Başar, CengizThe prevalence of myocardial involvement in influenza infection ranges from 0% to 11% depending on the diagnostic criteria used to define myocarditis. Whether such an association holds for the novel influenza A strain, pandemic-2009-H1N1, remains unknown. The clinical presentation of myocarditis varies and often mimics myocardial infarction. Although history, physical examination, laboratory data points, and electrocardiogram are helpful in distinguishing myocarditis from myocardial infarction, differential diagnosis can sometimes be difficult. Here, we present the first known report of acute myocarditis mimicking acute myocardial infarction associated with the pandemic influenza A virus (H1N1) infection. (Cardiol J 2011; 18, 5: 552-555)Öğe Akut koroner sendrom ile prezente olan ailesel Akdeniz Ateşi (FMF) olgusu(2009) Ordu, Serkan; Kaya, Ahmet; Aydın, Mesut; Dindar, Gökhan; Özhan, Hakan; Yazıcı, MehmetAilesel Akdeniz Ateşi (FMF), klinik olarak tekrarlayan peritonit, plevrit ve artrit gibi seröz zar tutulumuyla karakterize, histolojik ve laboratuar bulgularıyla lokalize veya sistemik inflamasyon kanıtları olan, otozomal resesif geçiş gösteren genetik bir hastalıktır. Sistemik inflamasyon, ateroskleroz başlangıcı ve gelişimi açısından önemli bir faktördür. Biz burada uzun süredir FMF tanısıyla tedavi alan bir hastanın, febril atakları esnasında akut koroner sendrom gelişerek semptom verebileceğini gösterdik.Öğe Angiotensin-converting enzyme, angiotensin II receptor, apolipoprotein E and endothelial constitutive nitric oxide synthase gene polymorphisms in dilated cardiomyopathy(2004) Özhan, Hakan; Zungur, Mustafa; Yazıcı, Mehmet; Akdemir, Ramazan; Gündüz, Hüseyin; Erbilen, Enver; Kaya, G.Genetic factors are hypothesized to contribute to the dilated cardiomyopathy (DCM) susceptibility, even in sporadic cases. Abundant reports have investigated the association between various gene polymorphisms and the phenotypic expression of DCM. The aim of the present study is to assess the effect of four candidate gene polymorphisms (1166 A/C polymorphism of the angiotensin II type 1 receptor (AGTR1) gene, I/D polymorphism of angiotensin converting enzyme (ACE) gene, endothelial nitric oxide synthase (ec-NOS) and apolipoprotein E (APOE genes) on the pathogenesis of dilated cardiomyopathy. We studied 76 consecutive patients (mean age 58±12) with DCM and 88 healthy age- and sex-matched control subjects (mean age 59±12). All patients were assessed by 2-dimensional echocardiography and all had left ventricular dilatation (end diastolic diameter >55 mm) and impaired systolic function (ejection fraction <40%). All patients were catheterized. Patients having normal coronary arteries were classified as 'idiopathic' and the remaining group as 'ischemic' DCM. Patients with specific heart muscle disease, isolated right ventricular dilatation and valvular or pericardial disease were excluded. Deoxyribonucleic acid (DNA) was isolated from blood samples, and genotypes were determined by specific polymerase chain reaction (PCR) and separation of amplified fragments by agarose gel electrophoresis. We compared genotypes and allele frequencies, echocardiographic measurements, biochemical variables in our patients and control group. Age, sex, body mass index differences were statistically non-significant. APO E genotypes and allele frequencies were significantly different in patients with DCM. Multiple regression analyses demonstrated lack of independent association. Subgroup analysis revealed that the four candidate gene polymorphisms were not associated with ischemic or idiopathic DCM. Conclusions: No significant association exists between dilated cardiomyopathy and polymorphism of the AGTR1, ACE, ecNOS and APOE gene polymorphisms.Öğe Assessment of cardiac functions in patients with adenotonsillar hypertrophy(2011) Ordu, Serkan; Özhan, Hakan; Uzun, Hakan; Alemdar, Recai; Erden, İsmail; Yazıcı, Mehmet; Gültekin, ErolAmaç: Bu çalışmanın amacı, adenotonsiller hipertrofisi (ATH) olan ve olmayan çocuklarda kardiyak fonksiyonları değerlendirmektir. Materyal ve Metod: Pediatri polikliniği tarafından adenotonsiller hipertrofi tanısı konmuş doksan bir çocuk (26 kız, 65 erkek) ve 23 sağlıklı olgu, yaş ve cinsiyet eşleştirilmeli sağlıklı çocuklar (10 kız, 13 erkek) çalışmaya dahil edilmiştir. Tüm hastalara 2D ekokardiyografi ve Doppler tetkiki yapılmıştır. Bulgular: Ortalama mitral E, A dalgaları ve deselerasyon zamanı, ATH olan grupta daha uzun bulunmuştur. Aynı zamanda kalp boşlukları ve hacimleri de daha yüksek ölçülmüştür. Pulmoner ve mitral regurjitasyon oranı, ATH olan grupta daha sık saptanmıştır. Adenotonsiller grade, ortalama pulmoner arterial basınçla ilişkili bulunmuştur. (r: 0.44 p: 0.001). Mitral kapak kalınlığı, tonsiller hipertrofi derecesiyle güçlü bir şekilde korele saptanmıştır. (r: 0.73; p.0.001). Sonuç: ATH, hafif diastolik disfonksiyon ve kalp boşluklarında dilatasyona yol açabilmektedir. Mitral kapak kalınlığı, adenotonsiller grad ile güçlü bir şekilde korele bulunmuştur.Öğe Assessment of myocardial performance index in hypertensive patients with or without hyperuricaemia(Via Medica, 2016) Başar, Cengiz; Beşli, Feyzullah; Özhan, Hakan; Türker, Yasin; Kayapınar, Osman; Keçebaş, MesutBackground: Myocardial performance index (MPI) is impaired in patients with hypertension. Uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation, and vasoconstriction. Hyperuricaemia may provide a negative contribution to impaired MPI in hypertension. Aim: The study was designed to assess the MPI in hypertensive patients with or without hyperuricaemia. Methods: A total of 96 consecutive hypertensive patients were divided into two groups according to levels of serum uric acid (SUA); 49 normouricaemic patients (defined as SUA < 7.0 mg/dL in men and < 6.0 mg/dL in women) and 47 hyperuricaemic patients. SUA levels and other biochemistry parameters were determined by a standard analytical technique. All patients were evaluated by two-dimensional and Doppler echocardiography. Results: The two groups were similar according to age, body mass index, and smoking status. Mean MPI value (0.498 +/- 0.06 vs. 0.410 +/- 0.05, p < 0.001) was significantly higher in the hyperuricaemic group than the normouricaemic individuals and positively correlated with the mean value of SUA levels (r = 0.51, p < 0.001). Conclusions: Our study demonstrated that high SUA levels were significantly associated with impaired MPI in hypertensive patients. SUA may suggest a valuable laboratory finding in assessing the risk of developing subclinical impaired left ventricular global function.Öğe Association of omentin Val109Asp polymorphism with coronary artery disease(Turkish Soc Cardiology, 2014) Yörük, Ümit; Yaykaşlı, Kürşat Oğuz; Özhan, Hakan; Memişoğulları, Ramazan; Karabacak, Ahmet; Bulur, Serkan; Kaya, ErtuğrulObjective: Coronary artery disease (CAD) is the most important morbidity and mortality disease in the world. It is also one of the leading causes of death in Turkey. Omentin, a recently found adipocytokine, is reported to regulate insulin sensitivity. It has anti-inflammatory properties and is inversely associated with CAD. Omentin gene polymorphism in patients with CAD has not been studied yet. The aim of this study is to investigate the relationship between omentin Val109Asp polymorphism and CAD. Methods: This is an observational study on genetic association. 157 consecutive patients who had undergone coronary angiography were included in the study. Seventy-five of them had CAD and the rest serves the control group. Val109Asp polymorphism was analyzed and compared. Chi-square test was used in comparison of genotype frequencies, whereas ANOVA and chi-square tests were used in comparison of clinical characteristics according to the genotypes. Results: There was no significant difference between CAD patients and control subjects regarding omentin Val109Asp polymorphism. However, a 2.5 fold increase in Val/Val (homozygous mutant) genotype was detected in patients with CAD. The OR (80% Cl) for Val/Val genotype was 3.46 (1.14-10.49). Conclusion: Although no significant difference was detected regarding omentin Val109Asp polymorphism, Val/Val genotype frequency was found to be more in patient group than control group. In conclusion, it may be speculated that Val/Val genotype increases the tendency for CAD, but this experiment should done with larger population to clarify this issue.Öğe Authors reply(Turkish Anaesthesiology and Intensive Care Society, 2013) Ertaş, Faruk; Kaya, Hasan; Özhan, Hakan[No abstract available]Öğe AV tam blokla gelen subklinik hipotiroidi olgusu(2008) Yazıcı, Mehmet; Koca, Emel Acar; Kaya, Ahmet; Özhan, Hakan; Balaban, YakupSubklinik hipotiroidi serum serbest tiroksin seviyesi normal sınırlarda iken serum tiroid stimülan hormon konsantrasyonunun referans aralığının üstünde tespit edilmesi olarak tanımlanmaktadır. Ateroskleroz riskinde artış, iskemik kalp hastalığı, sistolik ve diastolik disfonksiyon gibi çeşitli kardiyak bozukluklarla subklinik hipotiroidi arasındaki ilişki bilinmektedir. Burada AV tam blokla gelen ve levotiroksin tedavisi ile normal sinüs ritmine döndürülen subklinik hipotiroidili bir olgu sunulmaktadır.Öğe Carbohydrate Antigen-125 and N-Terminal Pro-Brain Natriuretic Peptide Levels Compared in Heart-Failure Prognostication(Texas Heart Inst, 2012) Ordu, Serkan; Özhan, Hakan; Alemdar, Recai; Aydın, Mesut; Çağlar, Onur; Yüksel, Hatice; Kandiş, HayatiCarbohydrate antigen-125 (CA-125) is emerging as a prognostic biomarker of risk in heart failure. In a prospective study, we compared the prognostic values of CA-125 and amino-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with stable heart failure. We enrolled 102 consecutive chronic, stable, systolic-heart-failure patients (68 men and 34 women; median age, 71 yr) from November 2008 through February 2010. We measured baseline NT-proBNP and CA-125 levels and compared their prognostic values. The primary endpoint was all-cause death and other major adverse events, defined as hospitalization for decompensated heart failure or acute coronary syndrome. During a mean follow-up period of 14 +/- 2 months, 12 patients died and 35 others sustained major adverse events. We found that CA-125 level significantly correlated with New York Heart Association functional class, pulmonary artery pressure, microalbuminuria, creatine kinase-MB fraction, and hemoglobin, albumin, and NT-proBNP levels. Upon receiver operating characteristic curve analysis, CA-125 and NT-proBNP had similar accuracy in predicting major adverse events and death: for major adverse events, area under the curve (AUG) was 0.699 for CA-125 (P=0.002) and 0.696 for NT-proBNP (P=0.002); for death, AUC was 0.784 for CA-125 (P=0.003) and 0.824 for NT-proBNP (P=0.001). Multivariate Cox regression analysis showed that CA-125 levels greater than 32 U/mL and NT-proBNP levels greater than 5,300 pg/mL had independent prognostic value for major adverse events and death. We conclude that baseline CA-125 and NT-proBNP levels are comparably reliable as heart-failure markers, and that CA-125 can be used for prognosis prediction in heart failure. (Tex Heart Inst J 2012;39(1):30-5)Öğe Carbohydrate antigen-125 and N-terminal pro-brain natriuretic peptide levels: Compared in heart-failure prognostication(2012) Ordu, Serkan; Özhan, Hakan; Alemdar, Recai; Aydın, Mesut; Çağlar, Onur; Yüksel, Hatice; Kandiş, HayatiCarbohydrate antigen-125 (CA-125) is emerging as a prognostic biomarker of risk in heart failure. In a prospective study, we compared the prognostic values of CA-125 and aminoterminal pro-brain natriuretic peptide (NT-proBNP) in patients with stable heart failure. We enrolled 102 consecutive chronic, stable, systolic-heart-failure patients (68 men and 34 women; median age, 71 yr) from November 2008 through February 2010. We measured baseline NT-proBNP and CA-125 levels and compared their prognostic values. The primary endpoint was all-cause death and other major adverse events, defined as hospitalization for decompensated heart failure or acute coronary syndrome. During a mean follow-up period of 14 ± 2 months, 12 patients died and 35 others sustained major adverse events. We found that CA-125 level significantly correlated with New York Heart Association functional class, pulmonary artery pressure, microalbuminuria, creatine kinase-MB fraction, and hemoglobin, albumin, and NT-proBNP levels. Upon receiver operating characteristic curve analysis, CA-125 and NT-proBNP had similar accuracy in predicting major adverse events and death: for major adverse events, area under the curve (AUC) was 0.699 for CA-125 (P=0.002) and 0.696 for NT-proBNP (P=0.002); for death, AUC was 0.784 for CA-125 (P=0.003) and 0.824 for NT-proBNP (P=0.001). Multivariate Cox regression analysis showed that CA-125 levels greater than 32 U/mL and NT-proBNP levels greater than 5,300 pg/mL had independent prognostic value for major adverse events and death. We conclude that baseline CA-125 and NT-proBNP levels are comparably reliable as heart-failure markers, and that CA-125 can be used for prognosis prediction in heart failure. © 2012 by the Texas Heart® Institute, Houston.Öğe Carotid intima media thickness and cardiometabolic risk associates in Turkish adults(Taylor & Francis Ltd, 2011) Beşir, Fahri Halit; Yazgan, Ömer; Özhan, Hakan; Aydın, Yusuf; Başar, Cengiz; Aydın, Mesut; Bulur, SerkanObjective Carotid intima media thickness (CIMT) is a strong predictor of future vascular events. However, data for Turkish individuals are limited and the association between cardiometabolic risk factors and CIMT has not been studied before. Therefore, we sought to investigate the CIMT and cardiometabolic risk associates in a large cohort of Turkish adults. Methods and results The study was conducted on 2230 participants (1427 women, 803 men with a mean age of 49). The participants underwent a Doppler Ultrasound examination of CIMT. Mean CIMT was 0.61 +/- 0.19 mm. Age- and sex-adjusted partial correlation analysis revealed that only systolic blood pressure and smoking amount was significantly correlated with CIMT. Receiver operator characteristics (ROC) calculations showed that age had the best area under the curve (AUC =0.84), smoking had the best sensitivity (86%) and diastolic blood pressure (>88 mmHg) had the best specificity (74%) in predicting a person with thickened carotid intima media (>0.8 mm). Independent predictors of thickened carotid intima media were hypertension [(odds ratio (OR) = 2.74; 95% confidence interval (Cl) = 1.663-4.53; P value <= 0.001)], systolic blood pressure [OR= 1.01; 95% Cl = 1.002-1.022; P value = 0.022] and age [OR= 1.11; 95% Cl = 1.079-1.136; P value <= 0.001). Conclusion Age, systolic blood pressure and smoking amount (pack/year) were the only age- and sex-adjusted associates of CIMT. Age had the best AUC in ROC analysis predicting thickened carotid artery intima media. Hypertension, systolic blood pressure and age were independent predictors of high CIMT in Turkish adults.Öğe A case of acute stent thrombosis treated successfully with intracoronary tirofiban(Via Medica, 2010) Erden, İsmail; Özhan, Hakan; Ordu, SerkanAcute stent thrombosis (AST) is occasionally observed during percutaneous coronary intervention in patients with acute coronary syndrome (ACS). It may jeopardize hemodynamic status. Currently, there is no adequate solution for this problem. We report our experience with an ACS patient who developed AST associated with cardiogenic shock after percutaneous coronary stent deployment. Intracoronary administration of tirofiban immediately restored the coronary flow of the target vessel, and the disastrous condition was reversed. Our experience suggests that intracoronary administration of tirofiban can be considered as an option in cases of AST during percutaneous coronary intervention.Öğe A case of infective endocarditis presented with a giant free wall vegetation [Serbest duvarda büyük hareketli vejetasyon ile kendisini belli eden infektif endokardit olgusu](2010) Sözen, Serhat Bahadır; Kaya, Ahmet; Cinemre, Hakan; Albayrak, Enver Sinan; Özhan, Hakan; Yazıcı, Mehmet[No abstract available]Öğe A case successfully treated giant ventricular septal rupture after acute myocardial infarction(Springer, 2007) Kaya, Ahmet; Kaya, Yasemin; Ordu, Serkan; Özkökeli, Mehmet; Özhan, Hakan; Dağlar, Bahadır; Mehmet, Yazıcı…Öğe Clinical and Echocardiographic Predictors of Left Atrial Thrombus Formation(Düzce Üniversitesi, 2010) Aydın, Mesut; Yazıcı, Mehmet; Erden, İsmail; Kayapınar, Osman; Kandiş, Hayati; Özhan, HakanAim: To investigate the relation between left atrial appendix function derived from quantitativetissue Doppler analysis and left atrial thrombus (LAT) existence. Methods: Fifty-six patients who had undergone transesophageal echocardiography (TEE) withdifferent diagnosis (31 female, 25 male with a mean age of 58 ± 18 years) were included in thestudy. Demographic, clinical and echocardiographic variables of the patients with and withoutLAT on their TEE were compared.Results: Atrial fibrillation was significantly more frequent in patients with LAT. The differencebetween mean ejection fractions was almost reached significance. However, left atrial andventricular tissue Doppler variables were similar between the two groups. Combined data oflower ejection fraction and atrial fibrillation predicted LAT with 85 % specificity. Conclusion: There is no statistical significance relation between left atrial appendix andventricular functions derived from quantitative tissue Doppler analysis and left atrial thrombus(LAT) existenceÖğe Clinical Characteristics and Outcome of Cardiovascular Implantable Electronic Device Infections in Turkey(Sage Publications Inc, 2016) Aydın, Mesut; Yıldız, Abdülkadir; Kaya, Zeynettin; Kaya, Zekeriya; Başarır, Ahmet Özgür; Çakmak, Nazmiye; Özhan, HakanInfection is one of the most devastating outcomes of cardiovascular implantable electronic device (CIED) implantation and is related to significant morbidity and mortality. In our country, there is no evaluation about CIED infection. Therefore, our aim was to investigate clinical characteristics and outcome of patients who had infection related to CIED implantation or replacement. The study included 144 consecutive patients with CIED infection treated at 11 major hospitals in Turkey from 2005 to 2014 retrospectively. We analyzed the medical files of all patients hospitalized with the diagnosis of CIED infection. Inclusion criteria were definite infection related to CIED implantation, replacement, or revision. Generator pocket infection, with or without bacteremia, was the most common clinical presentation, followed by CIED-related endocarditis. Coagulase-negative staphylococci and Staphylococcus aureus were the leading causative agents of CIED infection. Multivariate analysis showed that infective endocarditis and ejection fraction were the strongest predictors of in-hospital mortality.
