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    Synthesis of New Unsymmetrical Schiff Bases as Potential Antimicrobial Agents
    (Sinop Üniversitesi, 2020) Nartop, Dilek; Öğütcü, Hatice
    Novel unsymmetrical Schiff bases (L3a-L3c) were synthesized by using a two-stage method. The starting Schiff bases were prepared by the reaction of 2-aminophenol (or 2-amino-4-methylphenol or 2-amino-4-chlorophenol) with 1-nitro-2-naphthaldehyde. In these compounds, the nitro groups were reduced to amino groups using selective reducing agent and then 2-hydroxybenzaldehyde were added. Thus, three new unsymmetric Schiff base ligands were obtained. The antimicrobial activity of the synthesized unsymmetric Schiff bases were evaluated against some pathogenic strains (Shigella dysenteria type 7, Listeria monocytogenes 4b, Escherichia coli, Salmonella typhi H, Staphylococcus epidermis, Brucella abortus, Micrococcus luteus, Bacillus cereus sp., Pseudomonas putida sp.) and yeast (Candida albicans).
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    Synthesis, antimicrobial and antimutagenic effects of novel polymeric-Schiff bases including indol
    (Elsevier Science Bv, 2019) Nartop, Dilek; Özkan, Elvan Hasanoğlu; Gündem, Mehmet; Çeker, Selçuk; Ağar, Güleray; Öğütcü, Hatice; Sarı, Nurşen
    Herein, the synthesis and characterization of three new polymeric-Schiff bases including indol (L-1, L-2, L-3) were reported. The antibacterial and antifungal activity of all compounds were investigated by the well-diffusion method against some selected microorganisms as potential antimicrobial agents. In addition, the anti-genotoxic properties of these polymeric-Schiff bases were examined against sodium azide in human lymphocyte cells by micronuclei (MN) and sister chromatid exchange (SCE) tests. (C) 2019 Elsevier B.V. All rights reserved.