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    The Effect of Ozone Treatment on Thermal Burn Wound Healing; an Experimental Study
    (2020) Peker, Kemal; Yılmaz, İsmayil; Demiryılmaz, İsmail; Isık, Arda; Sayar, Ilyas; Gürsul, Cebrail; Çoban, Abdulkadir
    Objective: Ozone has been advised as a metabolic excitative in cell, immunomodulatory agent and antioxidant enzyme actuator. The present study was performedto designate the profit of ozone therapy on the burn wound healing in the rats.Methods: 40 adult Wistar type rats divided into 4 groups: a control group (burn notcreated and topical and systemic agents not used), a burn group (burn created but onlysaline given), a burn+silver sulfadiazine group (silver sulfadiazine was applied for 21days), a burn+ozone/oxygen mixture group (ozone/oxygen mixture was applied for 21days).After anesthetizing, second-degree burn (2 cm2areas) was done on the dorsal ofthe animals byaluminum plate in boiling hot water (100 ?C for 15 seconds) and othergroups except control group were treated topically, based on the time scheduled.Tissue samples were harvested on day 7st and 21st after burn injury. Biochemical andhistological analyzes were performed in tissue and blood samples. The results wereassessed with appropriate statistical tests and given as Means±SD.Results: The histopathologic damage level was significantly different in all groups.Fibrosis and inflamation levels decreased in ozone treatment and silver sulphadiazinegroups compared to burn+normal saline group on the 21 days according to 7 days. Inthe ozone treatment group, Glucose 6-phosphate dehydrogenase activities weresignificantly higher than the silver sulfadiazine treated group. But glutathionereductase enzyme activities were lover in the ozone treated group and hydroxyprolineconcentration decreased in ozone group compared to burn+normal saline group on 7and 21 days.Conclusions: Ozone has a detractive effect in the development of inflamation,fibrosis, and granulation via decreasing tissue damage and increasing the antioxidantenzyme activity on burn wound healing.