Hasırcı, UğurBurg, Timothy C.Groff, Richard E.2020-04-302020-04-302013978-1-4673-5769-2; 978-1-4673-5767-82072-5639https://hdl.handle.net/20.500.12684/30879th Asian Control Conference (ASCC) -- JUN 23-26, 2013 -- Istanbul, TURKEYWOS: 000333734900328A nonlinear adaptive backstepping controller for the anti-angiogenic tumor growth control problem is presented. The proposed control algorithm directly aims to drive the tumor volume along a desired trajectory as part of a treatment regimen. Toward this aim, we first present an exact-model knowledge controller that ensures the exponential tracking of a time-varying tumor volume profile, and then, an adaptive controller is shown that provides asymptotic tracking despite model uncertainties. A Lyapunov-based analysis approach is used to determine stability and performance results. Numerical simulation results are presented to demonstrate the performance of the proposed approach. Finally, the requirements of a real-time implementation of an in-vitro model of the overall system are discussed.eninfo:eu-repo/semantics/closedAccessConference ObjectN/A