Samancı, RümeysaAtaoğlu, SarfinazÖzşahin, MustafaAnkaralı, HandanAdmış, Özlem2021-12-012021-12-0120192148-49022536-4553https://doi.org/10.14744/nci.2019.95676https://app.trdizin.gov.tr/makale/TXpNNE5EUXlNZz09https://hdl.handle.net/20.500.12684/9223OBJECTIVE: In the present study, we aimed to compare serum irisin levels in patients with fibromyalgia syndrome (FMS) andhealthy control subjects and also investigate the relationship between irisin, disease activity and inflammation markers in patients.METHODS: A total of 84 women, including 48 patients who were diagnosed with FMS and 36 healthy controls, were included in this study. The demographic characteristics of the patients and control group were recorded. VAS for pain and theFibromyalgia Impact Questionnaire for the assessment of the physical function of the patients, SF36 was used for quality oflife, and accompanying Beck Depression Inventory to assess depression was used. Blood samples were taken for analysisthat irisin, and inflammatory markers of the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), high-sensitivityC-reactive protein (hs-CRP) and neutrophil/lymphocyte ratio (NLO). Serum irisin levels were determined using the EnzymeLinked Immunosorbent Assay (ELISA) method.RESULTS: Serum irisin level of the patients with FMS had no significant differences compared with the healthy control group.When we compared the values of ESR, CRP, hsCRP, NLO with FMS patients and healthy controls, there was no significant difference found between them (p>0.05). There was no significant correlation between inflammatory markers and level of serumirisin (p>0.05). In patients, there was no significant correlation between inflammatory markers and level of serum irisin (p>0.05).CONCLUSION: Irisin, which is a myokine, was determined to have no significant role in the pathogenesis of FMS. Irisin hadno association with disease activity and inflammatory markers. Also, the inflammation hypothesis was not supported, whichsuggested in FMS.en10.14744/nci.2019.95676info:eu-repo/semantics/openAccessGenel ve Dahili TıpArticle64341347