Keçeci, HulusiDeğirmenci, YıldızAtakay, Selçuk2020-05-012020-05-0120061543-3633https://doi.org/10.1097/01.wnn.0000213911.80019.c1https://hdl.handle.net/20.500.12684/6120WOS: 000240908100003PubMed: 16957490Objective: We aimed to see the consequences of habituation and posthabituation by means of repeatedly measuring the effects over a longer period. Method: The study was performed on 27 healthy volunteers. The event-related potentials were recorded from the Fz, the Cz, and the Pz electrode sites. The rare tone-frequent tone probability ratio was 20%. All subjects were asked to press a button when they heard a rare tone. The test was continued until 20 artifact-free rare tones were averaged, which was accepted as I trial block. After 10 trial blocks were obtained in a sequential manner, the test was completed. Result: This study has indicated that P300 amplitudes decrease with repeated stimulations, that is, there is a habituation period. As the test continues, the speed of amplitude decrease slows down and after a while it even starts to increase: that is, a dishabituation occurs. Conclusions: It is very likely that this habituation relates to a period of learning and dishabituation relates to a period of mental fatigue. In these processes, changes of amplitude and latency values reflect changes in amount of neuronal activation.en10.1097/01.wnn.0000213911.80019.c1info:eu-repo/semantics/closedAccessP300habituationdishabituationlearningneuroplasticityArticle193130134WOS:000240908100003Q1