Teberik, KuddusiEski, Mehmet TahirÇalışkan, EmelKılınçel, ÖzgeKaya, MuratAnkaralı, Handan2020-05-012020-05-0120190004-27491678-2925https://doi.org/10.5935/0004-2749.20190008https://hdl.handle.net/20.500.12684/5873WOS: 000455788400006PubMed: 30652764Purpose: To compare effects of 5% topical povidone iodine with prophylactic topical azithromycin and moxifloxacin on bacterial flora in patients undergoing intravitreal injection. Methods: A total of 132 patients were randomly assigned to receive treatment with azithromycin or moxifloxacin, or no treatment (control group). In total, 528 specimens were obtained at the time of admission, 4 days before intravitreal injection, 4 days after intravitreal injection, and 8 days after intravitreal injection. Samples were immediately sent to the microbiology laboratory for incubation. Results: The microorganism observed most frequently was coagulase-negative Staphylococcus (23.8%). When the results of samples obtained on Day 4 before injection were assessed, growth of coagulase-negative Staphylococcus was significantly lower in the moxifloxacin group, compared with controls (p=0.049). Acinetobacter baumannii continued to grow after administration of azithromycin (p=0.033). When the results of four days after intravitreal injection were evaluated, growth of coagulase-negative Staphylococcus was higher in controls, compared with patients who received azithromycin or moxifloxacin (p=0.004). Eradication rate was significantly higher in the moxifloxacin group than in the control group (p=0.001). Samples obtained on Day 8 after intravitreal injection showed similar levels of bacterial growth in all groups (p=0.217). Conclusion: Moxifloxacin was more effective than 5% povidone iodine in controlling the growth of conjunctival bacterial flora. Use of moxifloxacin in combination with 5% povidone iodine resulted in a synergistic effect.en10.5935/0004-2749.20190008info:eu-repo/semantics/openAccessAzithromycinConjunctiva/microbiologyIntravitreal injectionMoxifloxacinPovidone-iodineArticle8212531WOS:000455788400006Q3Q4