Karataş, AhmetErdem, HavvaKarataş, ZehraÖzlü, TülayÇakmak, Bülent2020-04-302020-04-3020170144-36151364-6893https://doi.org/10.1080/01443615.2016.1174825https://hdl.handle.net/20.500.12684/4912WOS: 000395199200003PubMed: 28013561Pendrin is important for transport of iodine across the placenta. Thiocyanate coming from cigarette is a competitive inhibitor of iodine transport. We aimed to evaluate the pendrin immunostaining intensity in placentas of smoker and non-smoker women. Placental tissues from 61 women, of which 28 were in smoking, and 33 were in non-smoking group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Birth weight was significantly lower in the smoker group (p=0.024). There was a negative correlation between birth weight and intensity of placental pendrin immunostaining in the smoker group (r=-0.44, p=0.02). Placentas of the smoking women showed significantly higher immunostaining with pendrin than the control group (p=0.006). Thiocyonate coming from cigarettes may competitively inhibit pendrin mediated iodine transport in the placenta and adversely affect foetal development by this mechanism.en10.1080/01443615.2016.1174825info:eu-repo/semantics/closedAccessPendrinplacentasmokingthiocyanateArticle3711114WOS:000395199200003Q3Q4