Kaya, ErtuğrulYılmaz, İsmailAdmış, ÖzlemOktay, MuratBayram, RecepBakırcı, SinanÇolakoğlu, Serdar2020-04-302020-04-3020161556-9543https://dx.doi.org/10.1080/15569543.2016.1178146https://hdl.handle.net/20.500.12684/271The aim of this study was to investigate beneficial effects of erdosteine in the alpha amanitine-induced hepatotoxicity in mice. Three hours after giving alpha amanitin (0.5 mg/kg, i.p.) to the mice, they were administered silibinin (50 mg/kg/d, i.p.) or erdosteine (100 mg/kg/d, oral) therapies once a day for 3 d. A histopathological examination of their liver tissues was carried out 24 h after the last treatment; transaminase levels, blood urea nitrogen, urea, and creatinine were analyzed in serum. Erdosteine showed a beneficial effect by significantly improving the functional parameters particularly in alpha amanitin-induced hepatotoxicity and partially in renal toxicity. In the histopathological evaluation, the toxicity that was generated with alpha amanitin was significantly reduced by erdosteine, showing a possible hepatoprotective effect. © 2016 Informa UK Limited, trading as Taylor & Francis Group.en10.1080/15569543.2016.1178146info:eu-repo/semantics/closedAccessAmanitin; erdosteine; hepatoprotection; hepatotoxicity; silibininArticle3501.Feb49Q3