Ünlü, İlhanSamim, Ethem Erdal2020-04-302020-04-3020141300-0381https://hdl.handle.net/20.500.12684/173Objective: Otitis media with effusion (OME) is a common childhood infection. Streptococcus pneumoniae and Haemophilus influenzae are very common bacterial pathogens in the etiology of OME. The purpose of the study is providing immunization against these pathogens and to see how it affects the course and recurrence of OME according to insert ventilation tube. Material and Methods: Ventilation tube was performed to 45 patients with OME between the ages of 2 to 13.H. influenzae type b conjugate vaccine and Pneumococcal polysaccharide vaccine containing 23 serotypes were applied together with an interval of 1 week to 35 patients between the ages of 2 to 13 who did not accept the application of ventilation tube. Patients with systemic diseases, immunodeficiency, allergy history, craniofacial malformations (for example, cleft palate, retrognathia, choanal atresia), previously application of the tube or history of ear surgery were excluded from the study. All patients were evaluated with pneumotoscopy and tympanometry at first week and at 1, 3, 6, 9, 12th months after the therapy and the findings were recorded. Results: The best results of vaccination group (VG) were obtained at the end of 12th month. Complete remission was observed in 24 (68.6%) patients and partial remission was observed in one patient at the end of 12th month. Also complete remission in 28 (62.2%) patients and partial remission in 3 (6.7%) patients was observed at the tube group (TG). Statistical analysis showed no significant difference between AT and TG in terms of healing rates (p?0.05). Conclusion: Vaccination of the patients with OME against S. pneumoniae and H. influenzae reduces the progression and recurrence of OME, but it's not more effective than ventilation tube. © 2014 by Türki ye Klinikleri.trinfo:eu-repo/semantics/closedAccessMiddle ear ventilation; Otitis media with effusion; VaccinationArticle2327480Q4