Karataş, AyşeGökçe, FatihDemir, ŞerifAnkaralı, Seyit2020-04-302020-04-3020080304-39401872-7972https://doi.org/10.1016/j.neulet.2008.08.071https://hdl.handle.net/20.500.12684/4872Ankarali, Seyit/0000-0003-3752-0846;WOS: 000260614900012PubMed: 18778752The opium alkaloid papaverine (PPV) Causes vasodilatation of the cerebral arteries through direct action on smooth muscle that reduces the constriction of smooth muscle. Intra-arterial papaverine (IAP) has been used widely to increase the regional cerebral blood flow in order to reverse the cerebral vasospasm that occurs during endovascular procedures. IAP-induced seizures have been reported, although PPV has anticonvulsive effects. This study determined the effects of LAP on electrocorticography (ECoG) in the ketamine anesthetized rats. We used 24 Sprague-Dawley male rats weighing 200-250 g. The animals were divided randomly into four groups: three treatment groups (groups 1-3) and a control (group,4). Groups 1, 2, and 3 were given 1, 7, and 14 mg/kg IAP, respectively. The ECoG was compared across groups. Our results indicate(] that IAP did not cause seizures and that it decreased the frequency of ketamine-induced epileptiform activity in the 14 mg/kg group. Crown Copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved.en10.1016/j.neulet.2008.08.071info:eu-repo/semantics/closedAccessPapaverineEpilepsyRatVasospasmSubarachnoid hemorrhageArticle44515861WOS:000260614900012Q2Q3