Akbaş, TürkayCoşkun, Sinem KantarcıoğluTorun, SerkanÖztürk, AyhanEsbah, OnurÖnbaş, Ömer2023-07-262023-07-2620221309-3878https://doi.org/10.18521/ktd.1019045https://hdl.handle.net/20.500.12684/12550Objective: Paraneoplastic neurological syndromes (PNSs) are a diverse group of neurological disorders affecting any part of the nervous system before or during cancer. Case: A 78-year-old man first experienced pain and burning in the upper extremity three years previously, to which muscle weakness was added a short time later. The same symptoms developed in the lower extremities one year previously. He was admitted to the intensive care unit due to pneumonia and was conscious but quadriplegic with a modified Rankin score of 5. Abdominal computed tomography showed mass lesions in the liver and pancreas. Biopsies revealed pancreatic small cell neuroendocrine carcinoma. Electrophysiological studies revealed severe sensorimotor axonal polyneuropathy. Paraneoplastic sensorimotor axonal polyneuropathy was diagnosed since other causes of polyneuropathy had been excluded. Palliative care was considered due to the patient's poor functional state. Conclusions: Early diagnosis of cancer is of paramount importance in patients with PNSs if appropriate treatment is to be provided.en10.18521/ktd.1019045info:eu-repo/semantics/openAccessNeuroendocrine Carcinoma; Quadriplegia; Ki67; Paraneoplastic Neurological SyndromesPrognostic-Factors; NeoplasmsReview Article142424428WOS:000821703000020N/A