Yalınay Dikmen, PınarŞahin, AyşenurIlgaz Aydınlar, ElifErdogan Soyukibar, TubaÖzge, AynurKaracı, RahşanTaşdelen, Bahar2026-07-012026-07-0120261300-0012https://doi.org/10.5606/agri.2026.21https://hdl.handle.net/20.500.12684/23132Background: This study aims to assess whether the Turkish version of the Migraine-Specific Quality of Life Questionnaire v2.1 (MSQ v2.1) is a reliable and valid tool for evaluating the impact of migraine on daily functioning and overall quality of life. Patients and Methods: This multi-center, descriptive, prospective study included a total of 182 migraine patients between December 2023 and May 2024. All patients were assessed at two visits with a four-week interval. The Turkish MSQ v2.1 was evaluated for comprehensibility, patient-physician reliability, internal consistency, test-retest reliability, and construct validity. Results: Of a total of 182 patients, 19 were male and 163 were female with a mean age of 40.8±12.2 (range, 18 to 73) years. Item comprehensibility was high, with 94 to 97.8% at Visit 1, and from 98.4 to 100% at Visit 2. A strong correlation was observed between self-administered and physician-administered MSQ v2.1 scores at Visit 1 (r = 0.916, p < 0.001). Internal consistency was excellent, with Cronbach’s alpha values of 0.932 at Visit 1 and 0.912 at Visit 2. Test-retest reliability was moderate (r = 0.468, p < 0.001). Construct validity was supported by strong correlations with the Headache Impact Test-6 (r = 0.751 at Visit 1 and r = 0.772 at Visit 2), monthly headache days (r = 0.453 and 0.553), and Numeric Rating Scale scores (r = 0.539 and 0.564), all with p < 0.001. Conclusion: The Turkish MSQ v2.1 is a reliable and valid tool for assessing health-related quality of life (HRQL) in migraine patients. It demonstrates excellent internal consistency, moderate test-retest reliability, and strong correlations with established measures of HRQL, headache severity, migraine frequency, and supporting its use in clinical practice and research. © 2026 The Author(s).en10.5606/agri.2026.21info:eu-repo/semantics/openAccessClinical scaleHealth-Related Quality of LifemigraineMigraine-Specific Quality of Life QuestionnairereliabilityvalidityArticle3828395421725182-s2.0-105037922806Q3