Nartop, DilekOzkan, Elvan HasanogluOgutcu, HaticeYetim, Nurdan KurnazOzdemir, Inci2025-10-112025-10-1120242046-2069https://doi.org/10.1039/d4ra04002chttps://hdl.handle.net/20.500.12684/21904In this paper, eight novel alpha-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectroscopy, molar conductance and magnetic susceptibility measurements. The in vitro antimicrobial activity of these complexes was examined against ten disease-causing pathogens: Gram-positive bacteria (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863) and Gram-negative bacteria (Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026) and yeast (Candida albicans Y-1200-NIH). The results revealed that the alpha-N-heterocyclic thiosemicarbazone compounds showed potent activity. It was observed that all thiosemicarbazone complexes were more susceptible to Gram-negative strains based on the presence of an electron-withdrawing substituent (-Br/-Cl/-F). It was determined that thiosemicarbazone Cu2+complexes showed stronger antifungal effects. In this paper, eight novel alpha-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via1H-NMR, IR, TGA, UV-Vis, molar conductance and magnetic susceptibility measurements.en10.1039/d4ra04002cinfo:eu-repo/semantics/openAccessArticle14402930829318392858852-s2.0-85204399815WOS:001313059900001Q1Q2