Erdem, HavvaOktay, MuratUzunlar, Ali KemalYıldırım, ÜmranAnkaralı, HandanYaşar, Mehmet2020-04-302020-04-3020131300-0144https://doi.org/10.3906/sag-1203-43https://hdl.handle.net/20.500.12684/2569oktay, murat/0000-0002-0893-4444; Ankarali, Handan Camdeviren/0000-0002-3613-0523; oktay, murat/0000-0002-0893-4444;WOS: 000321227400017Aim: The astrocyte-elevated gene-1 (AEG-1, also known as metadherin) is associated with various aspects of tumour malignancy; however, little knowledge is available related to the role of AEG-1 in ductal and lobular carcinomas. The aim of this study was to investigate the relationship of AEG-1 with the prognostic parameters in invasive ductal and lobular carcinomas. Materials and methods: This study was conducted on a total of 72 paraffin-embedded breast tumour samples. They consisted of 61 ductal and 11 lobular carcinomas. Breast tumour samples were stained for AEG-1. The prognostic parameters were compared with the results of AEG-1 stains. Results: We observed that more ductal carcinoma types than lobular carcinoma types resulted in high AEG-1 staining, whereas low AEG-1 staining occurred more in lobular carcinomas than in ductal carcinomas (P = 0.05). A significant negative correlation was also found between HER-2 (r = -0.30, P = 0.019) and AEG-1 (r = -0.804, P = 0.003) in lobular carcinomas. A significant relationship was found between increasing numbers of positive lymph nodes and AEG-1 in ductal carcinoma cases (P = 0.05). Conclusion: These results are consistent with previous reports of the role of AEG-1 in tumour progression. AEG-1 could be a useful marker for the development of new treatments and resistant hormonal therapy.en10.3906/sag-1203-43info:eu-repo/semantics/closedAccessDuctal carcinomaslobular carcinomasAEG-1prognostic parametersArticle4319398WOS:000321227400017Q3Q3