Orhan, ErsinKöse, MahmutAlkan, DemetÖztürk, Leyla2021-12-012021-12-0120192149-01202149-0120https://doi.org/10.18596/jotcsa.530757https://app.trdizin.gov.tr/makale/TXprMk16UTNOdz09https://hdl.handle.net/20.500.12684/9620Imidazole is a common and important heterocyclic fragment of many biologically importantmolecules. 5-imidazole-carbaldehydes containing mono- (N-1) methyl (or aryl) analogs are commonlyused as building blocks in medical chemistry. In this study, starting from 4-methyl-1H-imidazole-5-carbaldehyde, the N-1 atom of the imidazole ring is derived with different alkyl groups. In addition,both N atoms of the starting imidazole-carbaldehyde were methylated to give 5-carbaldehyde-1,3,4-trimethyl-3-imidazolium salt. The salt which possess quite reactive carbaldehyde group could be usedas a precursor for synthesis of other imidazolium derivatives. Furthermore, 4-methyl-5-imidazolecarbaldehyde was converted into the benzoxazole, benzothiazole and benzoimidazole by a two-stepreaction over the aldehyde group. These new compounds could display some biological activities.en10.18596/jotcsa.530757info:eu-repo/semantics/openAccess[No Keywords]Article63373382