Akcan, Fatih AlperDündar, YusufAkcan, Hümeyra BayramUluat, AhmetCebeci, DeryaÜnlü, İlhan2020-05-012020-05-0120190937-44771434-4726https://doi.org/10.1007/s00405-019-05286-yhttps://hdl.handle.net/20.500.12684/6405WOS: 000462155700018PubMed: 30643962ObjectivesThe main purpose of the current study was to investigate nasal mucociliary clearance time (NMC) in patients with Vitamin-D deficiency.MethodsA total of 55 patients with Vitamin-D deficiency and 32 controls were evaluated. NMC time was measured with subjective saccharine test and compared between study and control groups. In addition, NMC time was re-evaluated after Vitamin-D replacement protocol in patients with Vitamin-D deficiency.ResultsThe mean 25(HO)Vitamin-D levels were 14.324.23ng/mL (7-24.6) and 29.38 +/- 7.05ng/mL (25-53.8) in study and control groups, respectively (p<0.001). The mean NMC time was 11.15 +/- 3.05 (6.3-17.6) and 8.40 +/- 2.33 (6-13.2) in study and control groups, respectively (p<0.001). The mean 25(HO)Vitamin-D level after the replacement protocol was 33.38 +/- 10.03 and the mean NMC time was 9.56 +/- 2.54 (p<0.001).Conclusion The mean NMC time was significantly increased in patients with Vitamin-D deficiency which can be corrected after Vitamin-D replacement protocols. The prolonged mucociliary clearance might be one of the pathophysiologic pathways at increased upper respiratory tract infections, and sinonasal and ear infections in patients with Vitamin-D deficiency.en10.1007/s00405-019-05286-yinfo:eu-repo/semantics/closedAccessVitamin-DNasal mucociliary clearanceUpper respiratory tract infectionEar infectionArticle276410751080WOS:000462155700018Q1Q2