Sökmen, Bahar BilginGümrükçüoğlu, NurhanUğraş, SerpilŞahin, HüseyinSağkal, YaseminUğraş, Halil İbrahim2020-04-302020-04-3020150273-22891559-0291https://doi.org/10.1007/s12010-014-1307-2https://hdl.handle.net/20.500.12684/4727Sahin, Huseyin/0000-0002-6018-1494WOS: 000348103100007PubMed: 25342259The acylhydrazone compound named ethyl N'-furan-2-carbonylbenzohydrazonate was synthesized by the condensation of ethyl benzimidate hydrochloride with furan-2-carbohydrazide. The treatment of the acylhydrazone with hydrazine hydrate afforded 4-amino-3-furan-2-yl-5-phenyl-1,2,4-triazole. The usage of this compound with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. The obtained products were identified by FT-IR, H-1-NMR, C-13-NMR. A series of compounds were evaluated for their antibacterial, antiurease, and antioxidant activities. The results showed that the synthesized new compounds had effective antiurease and antioxidant activities.en10.1007/s12010-014-1307-2info:eu-repo/semantics/closedAccessAcyl hydrazone1,2,4-triazoleSchiff baseReductionUrease inhibition activityAntioxidant activityArticle1752705714WOS:000348103100007Q2Q3