Satır, EsraKendirli, Oguzhan2023-07-262023-07-2620221018-36472213-686Xhttps://doi.org/10.1016/j.jksus.2022.101838https://hdl.handle.net/20.500.12684/13498The growing rate of internet/network technologies day by day dramatically increases the formation of data in the world. As the flow of information increases on the network, time security threats are also increasing for users. In order to protect data, cryptography and steganography have been used from the past to the present. The goal of cryptography is to transfer the message between sender and receiver in a way that is incomprehensible to the observer. Nowadays, DNA cryptography is a shining branch in the field of cryptography. The primary purpose here is to employ DNA as a carrier and to employ modern biological techniques as application tools. In this study, a DNA cryptography technique was proposed by integrating DNA encoding and DNA operators into the Feistel network structure. Here, DNA itself was used as a carrier instead of traditional digital media such as image, text or video, while its biological tools were being used as implementation tools. Besides, the developed simulation software and the synthesized DNA sequence were digitally and biologically integrated into specifically created biotechnical hardware. Experimental results demonstrated that the proposed study has efficient outcomes for cryptographic requirements; capacity of nearly 100%, brute force attack nearly 12 x 10(6) years for only one block, key space that is 2(80) for only one block, and entropy analyses close to 2. Besides, the implementation of the proposed method has been verified by vitro experiments. (C) 2022 The Authors. Published by Elsevier B.V. on behalf of King Saud University.en10.1016/j.jksus.2022.101838info:eu-repo/semantics/openAccessDna Computing; Dna Encoding; Dna Encryption; Text Encryption; Security AnalysisCryptosystemArticle3432-s2.0-85124187720WOS:000755186700015Q1Q2