Öz, B.O.Alpay, M.Kaban, Ş.Ö.Sungur, M.A.Atao?lu, A.2024-08-232024-08-2320230353-5053https://doi.org/10.24869/psyd.2023.199https://hdl.handle.net/20.500.12684/14674Background: The aim of this study was to evaluate serum heat shock protein 70 (HSP70) and oxytocin levels, attachment and perceived social support levels in adolescents with parental bipolar disorder (BD) and Schizophrenia (SCZ). Subjects and Methods: This study included 9 adolescents with SCZ parents, 30 adolescents with BD parents and 31 healthy adolescents. Brief Symptom Inventory (BSI), Relationship Scale Questionnaire-Adolescent Form (RSQ-A) and Multidimensional Scale of Perceived Social Support (MSPSS) were administered to all participants. In addition, serum HSP-70 and oxytocin levels were evaluated. Results: There was no significant difference between the groups in terms of attachment style, psychiatric symptoms and perceived social support. Serum HSP-70 levels were found to be lower in adolescents whose parents had BD. Serum oxytocin levels of the SCZ group were significantly lower than those of the BD group. Conclusions: HSP-70 level was found to be lower in adolescents with BD parents. Oxytocin level was found to be lower in adolescents with SCZ parents. These findings suggest that HSP-70 and oxytocin may be a marker of early life stress in adolescents with parental psychopathology. However, studies are needed to evaluate the relationship between attachment, oxytocin and HSP-70 in adolescents exposed to parental psychopathology in early life. © 2023 Medicinska naklada & Pro mente, Zagreb, Croatia.en10.24869/psyd.2023.199info:eu-repo/semantics/openAccessadolescentsAttachmentbipolar disorderheat shock protein-70oxytocinAdolescentBipolar DisorderHSP70 Heat-Shock ProteinsHumansOxytocinParentsSchizophreniaantidepressant agentheat shock protein 70methylphenidateneuroleptic agentoxytocinheat shock protein 70oxytocinadolescentadultanxietyanxiety disorderArticleattention deficit hyperactivity disorderbipolar disorderBrief Symptom Inventorychildconduct disordercontrolled studydepressionemotional attachmentfamilyfemalefriendhostilityhumanmajor depressionmaleMultidimensional Scale of Perceived Social Supportnegative valenceoxytocin blood levelprotein blood levelquestionnaireRelationship Scale Questionnaire Adolescent Formschizophreniasocial supportsomatizationbipolar disorderchild parent relationmetabolismpsychologyschizophreniaArticle352199209374803072-s2.0-85166964044Q3