Kahraman, CemilRendi, T. AhmadiSağlam, NeslihanAkça, İmran İnceAbidin, İsmailAlver, Ahmet2023-07-262023-07-2620220022-09301608-3202https://doi.org/10.1134/S0022093022020090https://hdl.handle.net/20.500.12684/12499The sympathetic nervous system (SNS) plays an important role in regulating the metabolic and secretory functions of white adipose tissue. In this study, it was aimed to investigate the long term effects of bilateral retroperitoneal adipose tissue denervation and high fat diet (HFD) on general metabolic status and serum levels of some adipokines in rats. For this purpose, we fed denervated and control rats with control and high fat diet for 70 days. At the end of the feeding program, denervation caused an increase in serum triglyceride (p < 0.01), leptin (p < 0.05) and adiponectin levels (p < 0.01), as well as body weight (p < 0.05) in the group with the control diet (CD). We also observed that the serum adiponectin levels (p < 0.05), of the animals in the denervated HFD group was higher than the non-denervated group whereas the body weight and leptin/adiponectin ratio were reduced. Our data indicate that bilateral denervation of a pad of white adipose tissue in rats causes different changes in metabolic parameters and circulating adipokine levels at different energy states, and in the long term, while denervation mimicked obesity in the control diet group, it to some extent suppressed the effects of a high fat diet in the HFD group.en10.1134/S0022093022020090info:eu-repo/semantics/closedAccessAdipose Tissue; Adipokines; Bilateral Denervation; Body Weight; High Fat Diet; Insulin; Leptin; Norepinephrine; Resistin; TriglyceridesInsulin-Resistance; White; Adiponectin; Innervation; ExpressionArticle582410417WOS:000796544500009Q4