Eröz, RecepOkur, M.Özkan, A.Berik, O.Güneş, C.2020-05-012020-05-0120121015-8146https://hdl.handle.net/20.500.12684/5611WOS: 000306574200014PubMed: 22876584Does higher NORs expression affect the developmental stages of Down syndrome infants?: Background: The nucleolar organizer regions (NORs) are localized at the secondary constriction of the five pairs of acrocentric chromosomes (13, 14, 15,21 and 22) in human. Materials and Methods: To evaluate whether increasing AgNOR protein synthesis effects or not the development of babies/children, 25 Down syndrome patients were included in this study. Firstly, the Ankara Development Screening Inventory (AGTE) test was performed. Then the buccal epithelial cells of patients were taken via a sterile toothpick on clean glass slides and spreaded and AgNOR staining technique was applied to the slides of each individual. Mean NOR area/Total nucleus area (NORa/TNa) were evaluated for each nucleus using a special computer program. Results: The mean NORa/TNa was found to be 3.8 +/- 1.16. According to these data, a significant correlation was not evident between the NORa/TNa and developmental stages (p > 0.05). Conclusions: There is no correlation between extra energy spending for NOR protein synthesis and developmental deficiency.eninfo:eu-repo/semantics/closedAccessNORAgNORrDNADown syndromeArticle232249253WOS:000306574200014N/AQ4