Uçan, BekirŞahin, MustafaÖnal, BinnurKizilgul, MuhammedDuger, HakanSencar, Muhammed ErkamÇakal, Erman2023-07-262023-07-2620211300-01441303-6165https://doi.org/10.3906/sag-2101-246https://hdl.handle.net/20.500.12684/12378Background/aim: The management of nodules with indeterminate cytology [atypia of undetermined significance (AUS), follicular lesion of undetermined significance (FLUS), follicular neoplasm (FN), suspicious for a follicular neoplasm (SFN), and suspicious for malignancy (SM)] results is controversial. To assess the role of the elastography technique in the diagnosis of malignancy in the subtypes of indeterminate thyroid nodules. Materials and methods: We included 132 patients with indeterminate cytology who underwent thyroid surgery. Sensitivity, specificity, area under the curve, and optimal cut-off points were calculated with receiver operating characteristic (ROC) analysis for elastography score (ES) and strain index (SI). Results: Malignancy was observed in 27/95 (28.4%) of the AUS-FLUS cytology and 12/24 (50%) of FN, SFN cytology. All of the 13 patients (100 %) with SM are found to be malignant on histology. In the FLUS group, nodules with ES greater or equal to 3, the presence of malignancy was higher 17/41 (41.5%) when compared with nodules with ES smaller than 39/46 (19.6 %) (p = 0.023). In the SFN group, 2 of 2 nodules with an ES score of 4 and 1 of 1 nodule with an ES score of 5 were malignant. In the FLUS group, 4 of 10 nodules with an ES score of 4 and 2 of 2 nodules with an ES score of 5 were malignant. Conclusion: Thyroid elastography may reduce unnecessary surgery for both patients with AUS/FLUS and selected SFN cytology. Elastography appears to be helpful in follicular variants and other types of papillary thyroid cancer, however, not in follicular thyroid cancer.en10.3906/sag-2101-246info:eu-repo/semantics/openAccessElastography; Indeterminate Cytology; Malignancy; ThyroidFine-Needle-Aspiration; Undetermined Significance; Association Guidelines; Bethesda System; Ultrasonography; Expression; Malignancy; Management; AtypiaArticle51629242930342896512-s2.0-85122973549WOS:000731456300015Q3Q3