Kahyaoğlu, İnciDemir, BerfuTürkkanı, AytenÇınar, ÖzgürDilbaz, SerdarDilbaz, BernaMollamahmutoğlu, Leyla2020-04-302020-04-3020141058-04681573-7330https://doi.org/10.1007/s10815-014-0281-5https://hdl.handle.net/20.500.12684/5240WOS: 000341829700005PubMed: 24962788To study parameters that could predict in-vitro fertilization (IVF) success in patients who experienced total fertilization failure (TFF) with intracytoplasmic sperm injection (ICSI) in their previous cycles. Cycle characteristics of patients with TFF (Group I, n = 136 cycles), cycles resulting in embryo transfer (ET) following TFF (Group II, n = 36 cycles) and recurrent TFF (Group III, n = 25 cycles) and were studied retrospectively. Demographic features, cycle characteristics of three groups were compared. Follicle count measuring 15-17 mm was significantly higher in group II when compared to group I (p = 0.02). Total number of retrieved oocytes and mature oocytes were significantly higher in group II when compared to groups I and III (p = 0.001). Estradiol level at oocyte pick up (OPU) day was significantly higher in group II when compared to group I (p = 0.02). When the characteristics of ET cycles and preceding TFF cycles of the same patient were compared, total number of retrieved oocytes (5.11 +/- 0.72 (95 % CI 3.69-6.52) vs. 11.44 +/- 1.60 (95 % CI 5.29-17.59)) and mature oocytes (3.26 +/- 3.66 (95 % CI 2.04-4.47) vs. 6.92 +/- 5.61 (95 % CI 5.09-8.75)) were found to be significantly lower in TFF cycles (p = 0.001). Five biochemical and 5 clinical pregnancies occurred while only 2 healthy babies were born, corresponding to a live birth rate 5.5 %. Increasing the number of retrieved and mature oocytes may increase the success of fertilization in patients with a history of previous failed fertilization. However, live birth rate is still low in embryo transfer cycles.en10.1007/s10815-014-0281-5info:eu-repo/semantics/openAccessTotal fertilization failureIntracytoplasmic sperm injectionMature oocytePoor responderDiminished ovarian reserveArticle31911551160WOS:000341829700005Q2Q3